Etiology of hypercholesterolemia in patients with anorexia nervosa

Ohwada, Rina; Hotta, Mari; Oikawa, Shinichi; Takano, Kazue

doi:10.1002/eat.20298

Cited by 68 publications

(54 citation statements)

References 11 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the serum total cholesterol values in patients with AN in previously published papers were widely distributed (10,11,(17)(18)(19)(20)(21). Although the frequency of cardiac events in patients with BN is not clear, the serum cholesterol values in patients with BN were also widely distributed (22)(23)(24)(25)(26).…”

Section: Discussionmentioning

confidence: 94%

“…Available evidence suggests that cholesterol elevation in AN may be due to liver dysfunction, dehydration, reduced cholesterol turnover (18), decreased triiodothyronine concentrations (10), and delayed cholesterol metabolism (11). Raised cholesterol concentrations in BN may be associated with the feeding pattern (22) and dietary intake of cholesterol and fat during binge-eating episodes (24).…”

Section: Discussionmentioning

confidence: 99%

“…There are some reports on the lipid levels in patients with AN in Japan (10,11). However, to the best of our knowledge, there is no report on the lipid levels in BN and bingeeating disorder (BED) in Japan.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Serum Lipid Levels in Patients with Eating Disorders

Nakai¹,

Noma

Fukusima

et al. 2016

Intern. Med.

View full text Add to dashboard Cite

Objective To evaluate some risk factors for cardiovascular diseases in feeding and eating disorders, the degree of lipid abnormalities was investigated in a large Japanese cohort of different groups of feeding and eating disorders, according to the Japan Atherosclerosis Society Guidelines for the Prevention of Atherosclerotic Cardiovascular Diseases 2012 (JAS Guidelines 2012). Methods Participants in the current study included 732 women divided into four groups of feeding and eating disorders: anorexia nervosa, restricting type (AN-R); anorexia nervosa, binge-eating/purging type; bulimia nervosa (BN); and binge-eating disorder (BED). We measured the serum levels of total cholesterol, highdensity-lipoprotein (HDL) cholesterol, and triglyceride in these participants. Low-density-lipoprotein (LDL) cholesterol and non-HDL cholesterol levels were also calculated. Results The concentrations of LDL cholesterol and non-HDL cholesterol were widely distributed in all groups. When the LDL cholesterol risk was defined as ! 120 mg/dL and the non-HDL cholesterol risk as ! 150 mg/dL, according to the JAS Guidelines 2012, the proportion of LDL cholesterol risk ranged from 29.6% (BN) to 38.6% (AN-R), and the proportion of non-HDL cholesterol risk ranged from 17.8% (BN) to 30.1% (BED). Conclusion The present findings suggest the existence of LDL cholesterol risk and non-HDL cholesterol risk in all groups of eating disorders. Given the chronicity of this condition, the development of elevated concentrations of LDL cholesterol and non-HDL cholesterol at an early age may increase the risk of cardiovascular diseases.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Serum Lipid Levels in Patients with Eating Disorders

Nakai¹,

Noma

Fukusima

et al. 2016

Intern. Med.

View full text Add to dashboard Cite

show abstract

“…in type 1 diabetes [6] , advanced stages of chronic kidney disease [5,8] , and starvation [9][10][11] . Further, IR is also seen in conditions where body fat is often low, including congenital lipodystrophies [12] , anorexia nervosa [13] , and chronic stress conditions [14] .…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemia: A Possible Link between Insulin Resistance, Metabolic Dyslipidemia, and Heart and Kidney Disease (the Cardiorenal Syndrome)

2011

View full text Add to dashboard Cite

Resistance to insulin metabolic signaling in adipose tissue contributes to the lipid abnormalities in obese, hyperinsulinemic, insulin-resistant patients who develop the cardiorenal syndrome. These same metabolic dyslipidemic abnormalities can be found in conditions of caloric energy restriction with decreased adiposity or normal insulin levels, such as anorexia, starvation or non-diabetic kidney disease. In this review, we assess hypoglycemia as an alternative physiological explanation for the biochemical and lipid findings in conditions of insulin resistance (IR). Therefore, PubMed databases were searched for articles on the effect of hypoglycemia and starvation on non-esterified fatty acid (NEFA) elevation and abnormalities in insulin signaling in muscles as well as abnormal kidney metabolism. The search included articles on NEFA and their role in triglyceride (TG) and high-density lipoprotein (HDL) metabolism, as well as kidney and heart disease. Available studies support that hypoglycemia increases NEFA generation from adipose tissue. Elevated levels of NEFA induce increased plasma levels of TG and decreased levels of HDL cholesterol, and may cause direct kidney and myocardial damage. IR of adipose and skeletal muscle tissue, and the elevation in insulin levels in obese, insulin-resistant patients could be explained by an adaptation to their carbohydrate intake. These molecular abnormalities in insulin metabolic signaling can also be found in hypoglycemia or starvation. In conclusion, IR of adipose tissue cannot fully explain the lipid ab- normalities observed in the cardiorenal syndrome. Decreased blood glucose levels (e.g. hypoglycemia) occur frequently in patients at risk for this syndrome. Hypoglycemia-induced increases in NEFA levels can promote lipid abnormalities that contribute to IR and the cardiorenal syndrome.

show abstract

“…Vários autores relataram baixa ingestão de ácido fólico nas pessoas com TAs (HADIGAN et al, 2000;LORIA-KOHEN et al, 2009 O perfil lipídico aumentado esteve presente em, pelo menos, 50% dos pacientes com distúrbio alimentar (MONTELEONE et al 2005;OHWADA et al, 2006); tanto nos indivíduos com AN (MATZKIN et al, 2006;NOVA et al, 2008;OHWADA et al, 2006;RIGAUD;TALLONNEAU;VERGÈS, 2009) como nos com BN (MONTELEONE et al 2005PAUPORTE;WALSH, 2001). …”

Section: Discussão | 67unclassified

Indicadores clínicos e bioquímicos de risco cardiovascular em adultos com transtornos alimentares

Teraoka¹

View full text Add to dashboard Cite

2 ; 86,4% apresentaram valores de CA normais; 95% com ITB normal, 70% com delta ITB (diferença entre os ITBs) normal; 95,4% com cifras de PA inferiores a 120x80 mmHg, 18,2% com pulso radial inferior a 60 batimentos por minuto; 9,1% com pressão de pulso >50 mmHg. A soma das quatro dobras cutâneas foi de 62,05 ± 19,92 mm, e o percentual de gordura foi de 28,95 ± 5,65; 47,6% classificaram-se como acima da média para o risco de morbidade, devido à alta porcentagem de gordura corporal, de acordo com as dobras cutâneas. Quanto aos exames bioquímicos, 42,1% apresentaram aumento nos níveis do colesterol total; 33,3%, aumento do LDL-C, 10,5%, aumento nos níveis de triglicérides, 18,2%, aumento da homocisteína, 31,8%, aumento do ácido fólico, 4,5%, da PCR e 9,0% estavam com níveis de vitamina B 12 maiores ou menores do que os valores de referência. Houve associação estatisticamente significante para a associação entre o IMC e o diagnóstico de AN e bulimia nervosa, p=0,002. Concluímos que as pessoas com TA apresentaram indicadores clínicos e bioquímicos de risco cardiovascular, devendo ser adotadas medidas e ações preventivas que priorizem a promoção da saúde neste grupo de indivíduos. This is a cross-sectional descriptive study with quantitative approach that aim to find out the clinical and biochemical indicators of cardiovascular risk among people diagnosed with eating disorders (ED). The population was composed of 22 users an outpatient follow-up from two university hospitals located on the countryside and capital of São Paulo during the period from March 2013 to February 2014. The data collection occurred through interview to identify socio-demographic variables such as age, sex, skin color, marital status, education, and family income. The clinical data collected from anthropometric assessment were height, weight, waist circumference (WC), and body mass index (BMI); skinfold-thickness measurement: triceps, biceps, subscapular and suprailiac; indirect measurement of blood pressure (BP) and ankle-brachial index (ABI); body fat percentage. Laboratory examinations were carried out to identify the presence of C-reactive protein (CRP), cholesterol (total or individual components), triglycerides, homocysteine, vitamin B 12 , and folic acid. The data were grouped into categories and the quantitative variables were expressed as median and standard deviation. It was used SPSS (Statistical Package for the Social Science), version 16.0 and R i386 version 3.0.0 and the significance level adopted was α=0.05. It was used the Fisher Exact Test for association analysis between BMI classification (eutrophic and low weight) with clinical, anthropometric and biochemical variables. The average age of participants was 28.41 ± 7.51 years, female (95.5%), white (86.4%), not living with a partner (72.7%), students (45.5%), employment relationship (31.9%), bachelor degree in progress or incomplete (31.8%) with average study of 12.45 ± 2.94 years, and family income between three and four minimum wages (59.1%); the medical diagnosis presented t...

show abstract

Etiology of hypercholesterolemia in patients with anorexia nervosa

Abstract: Serum levels of cholesterol, CETP, and apolipoproteins decreased after weight gain, indicating that cholesterol metabolism is accelerated in patients with AN with normal serum levels of FFA.

Cited by 68 publications

References 11 publications

Serum Lipid Levels in Patients with Eating Disorders

Serum Lipid Levels in Patients with Eating Disorders

Hypoglycemia: A Possible Link between Insulin Resistance, Metabolic Dyslipidemia, and Heart and Kidney Disease (the Cardiorenal Syndrome)

Indicadores clínicos e bioquímicos de risco cardiovascular em adultos com transtornos alimentares

Contact Info

Product

Resources

About