Etiology of malign bone tumors

Abstract

Primary malignant bone tumors constitute a very small part of adult cancers. However, osteosarcomas constitute approximately half of all malignant bone tumors in ages between 15 to 29 years. This is followed by Ewing sarcoma primitive neuroectodermal tumors of bone and chondrosarcoma. Factors affecting malignant bone tumors include genetics, race, sex, growth and development age, radiotherapy treatment, radioactive substances, chemotherapy treatment, trauma, chemical substances, predisposing lesions, X-rays, and immune deficiency. Determining possible familial and genetic risk factors and predisposing agents and therefore informing families on avoiding physical and chemical exposure may be the most important factors in preventing malignancy. In this article, we aimed to discuss factors affecting the development of malignant bone tumors.