Etiology of multiple sclerosis: role of superoxide dismutase

Lund-Olesen, K

doi:10.1054/mehy.1999.0841

Cited by 10 publications

(2 citation statements)

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“…To date, studies have shown alterations in the levels of specific endogenous anti-oxidant enzymes and markers of oxidative stress in serum, cerebrospinal fluid (CSF) and brain tissue derived from patients with MS (Calabrese et al, 2002;Lund-Olesen, 2000;Tajouri et al, 2003;van Horssen et al, 2008). However, a clear understanding of precise mechanisms of tissue injury in MS is lacking, particularly in key pathological sites such as the cerebellum.…”

Section: Introductionmentioning

confidence: 99%

Oxidative injury in multiple sclerosis cerebellar grey matter

et al. 2016

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. AbstractCerebellar dysfunction is a significant contributor to disability in multiple sclerosis (MS). Both white matter (WM) and grey matter (GM) injury occurs within MS cerebellum and, within GM, demyelination, inflammatory cell infiltration and neuronal injury contribute to on-going pathology. The precise nature of cerebellar GM injury is, however, unknown. Oxidative stress pathways with ultimate lipid peroxidation and cell membrane injury occur extensively in MS and the purpose of this study was to investigate these processes in MS cerebellar GM. Post-mortem human cerebellar GM from MS and control subjects was analysed immunohistochemically, followed by semi-quantitative analysis of markers of cellular injury, lipid peroxidation and antioxidant enzyme expression. We have shown evidence for reduction in myelin and neuronal markers in MS GM, coupled to an increase in expression of a microglial marker. We also show that the lipid peroxidation product 4-hydroxynonenal co-localises with myelin and its levels negatively correlate to myelin basic protein levels. Furthermore, superoxide dismutase (SOD1 and 2) enzymes, localised within cerebellar neurons, are up-regulated, yet the activation of subsequent enzymes responsible for the detoxification of hydrogen peroxide, catalase and glutathione peroxidase are relatively deficient. These studies provide evidence for oxidative injury in MS cerebellar GM and further help define disease mechanisms within the MS brain.

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Section: Introductionmentioning

confidence: 99%

Oxidative injury in multiple sclerosis cerebellar grey matter

et al. 2016

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“…And evidence suggests that boosting falling SOD levels may help guard against disease and extend life span [75]. Low SOD levels in humans have also been associated with a host of degenerative diseases, including fibromyalgia [76], diabetes [77], cancer [78], multiple sclerosis [79], Alzheimer's and Parkinson's disease [80]. Increased level of SOD in plants, can protect the host against physical and chemical stress, and improve the biomass production with larger shoot, crown, and root systems [81][82][83].…”

Section: Applications Referencementioning

confidence: 99%

Sources of marine superoxide dismutases: Characteristics and applications

Zeinali

Homaei

Kamrani

2015

International Journal of Biological Macromolecules

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Proteomic analysis of cerebrospinal fluid from multiple sclerosis patients

et al. 2004

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Multiple sclerosis is an autoimmune inflammatory demyelinating disease of the central nervous system. Disease mechanisms in multiple sclerosis at the molecular level remain poorly understood and no reliable proteinaceous disease markers are available yet. The goal of the present study is the construction of a protein database of two-dimensional gel electrophoresis (2-DE) separated cerebrospinal fluid (CSF) proteins from multiple sclerosis patients. By means of liquid chromatography tandem mass spectrometry 65 different proteins were identified from 300 spots. Eighteen of these proteins have not been reported previously on 2-DE gels of CSF. Here we report on the identification of these proteins and discuss their potential relation to multiple sclerosis.

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Etiology of multiple sclerosis: role of superoxide dismutase

Cited by 10 publications

References 1 publication

Oxidative injury in multiple sclerosis cerebellar grey matter

Oxidative injury in multiple sclerosis cerebellar grey matter

Sources of marine superoxide dismutases: Characteristics and applications

Proteomic analysis of cerebrospinal fluid from multiple sclerosis patients

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