Etiology of Recurrent Pregnancy Losses and Outcome of Subsequent Pregnancies

Harger, James H.; Archer, David F.; Marchese, Sandra; Muracca-Clemens, Michele; Garver, Kenneth L.

doi:10.1097/00006254-198406000-00019

Cited by 94 publications

(77 citation statements)

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“…Both organisms have been associated with increased risk of recurrent pregnancy losses [8,9], genitourinary tract infections which include pyelonephritis, pelvic inflammatory disease (PID), chorioamnionitis, postpartum and postabortal fever [10][11][12][13]. Whether these organisms cause involuntary infertility through fertilization or implantation impairment remains speculative.…”

Section: Introductionmentioning

confidence: 99%

The prevalence of ureaplasma urealyticum, mycoplasma hominis, chlamydia trachomatis and neisseria gonorrhoeae infections, and the rubella status of patients undergoing an initial infertility evaluation

Imudia

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et al. 2008

J Assist Reprod Genet

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Purpose To determine the prevalence of positive test for Ureaplasma urealyticum (UU), Mycoplasma hominis (MH), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) infections, and their corresponding Rubella status when undergoing workup for infertility. Methods Retrospective chart review to determine infection status for UU, MH, CT, and NG as determined by cervical swab, as well as the serum Rubella antibody titer. Results A total of 46 patients of the patients reviewed were positive for UU (20.1%), three patients were positive for MH (1.3%), five patients were positive for CT (2.2%) and one patient was positive for NG (0.4%). Rubella immunity was confirmed in 90.3% of patients. Conclusion Approximately one quarter of women presenting to an infertility clinic seeking to conceive were found to have a positive test for UU, MH, CT or NG infection. Additionally, almost 10% of the patients were Rubella nonimmune at the time of presentation for infertility evaluation.

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Section: Introductionmentioning

confidence: 99%

The prevalence of ureaplasma urealyticum, mycoplasma hominis, chlamydia trachomatis and neisseria gonorrhoeae infections, and the rubella status of patients undergoing an initial infertility evaluation

Imudia

Detti

Puscheck

et al. 2008

J Assist Reprod Genet

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“…2,3 Chromosomal abnormalities are mentioned as responsible for 50 to 60% of spontaneous abortions in the fi rst trimester, 4 including numerical aberrations, translocations and mosaicism. 5 Qualitative semen evaluation is currently suggested for investigations of the causes of RSA. 6 Uterine anatomical defects and an incompetent cervix predispose women to abortion and premature delivery, accounting for 15 to 27% of RSA cases.…”

Section: Introductionmentioning

confidence: 99%

“…6 Uterine anatomical defects and an incompetent cervix predispose women to abortion and premature delivery, accounting for 15 to 27% of RSA cases. 5,7 Changes in hormonal patterns have also been implicated as causes of RSA. Low progesterone production renders endometrial maturation inadequate for nidation and egg development.…”

Section: Introductionmentioning

confidence: 99%

Gestational prognostic factors in women with recurrent spontaneous abortion

et al. 2006

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CONTEXT AND OBJECTIVE: Recurrent spontaneous abortion (RSA) is defined as three or more consecutive pregnancy losses before 20 weeks and is associated with several etiological factors related to genetics, anatomy, hormones, infections and immunology, for example. Many cases of RSA remain unclear. New factors or their associations may influence gestational results. The aim was to identify possible single or associated causes of RSA that could predict gestational prognosis for women undergoing investigation and treatment. DESIGN AND SETTING: Case-control study, at the Recurrent Abortion Outpatient Clinic, Department of Obstetrics and Gynecology School of Medicine, Universidade Estadual de Campinas (Unicamp). METHODS: Two hundred and forty-six medical records of women with RSA seen at the Recurrent Abortion Outpatient Clinic, Department of Obstetrics and Gynecology School of Medicine, Universidade Estadual de Campinas (Unicamp), between 1994 and 2003, were evaluated. Data on age, obstetric history, possible etiological factors, treatment and pregnancy outcomes were evaluated. Statistical analysis was performed using odds ratios (OR), logistic regression analysis and decision trees. RESULTS: Two hundred and twenty-nine women were included in the study. The most frequently found etiological factors were immunological, particularly alloimmune factors (93.9%). Women with a single alloimmune factor had better gestational results (77.7% deliveries) than those with other associated factors. Autoimmune factors were associated with a higher abortion rate (OR: 4.30; 95% confidence interval, CI: 1.36-13.63). No association was found between the number of abortions prior to treatment and pregnancy results. Women aged 40 or over presented the highest rate of spontaneous abortion (OR: 5.83; 95% CI: 1.12-30.40). CONCLUSION: Age over 40 years old, immunological factors and two or more concomitant factors were associated with poor gestational outcomes among the women studied.

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“…O aborto espontâneo recorrente (AER) é caracterizado pela perda espontânea e consecutiva de três ou mais gestações até a 20ª semana de gravidez (Regan, 1998;Bansal, 2010), e acomete cerca de 1 a 2% das mulheres que estão na idade reprodutiva e pode chegar até 5% se levado em consideração as mulheres com duas perdas fetais consecutivas (Harger et al, 1983;Carrington, Sacks e Regan, 2005;Brenner, 2010). No entanto, a medida que as mulheres apresentam o evento do aborto, o risco de que a próxima gestação não seja bem sucedida aumenta de forma gradativa quando o aborto se repete (Barini e Al, 2000).…”

Section: Introductionunclassified

“…Na fase inicial, denominada hemostasia primária, ocorre vasoconstrição logo após o rompimento do vaso e tem como função diminuir o fluxo sanguíneo no local. Isso permite um maior contado entre as plaquetas que estão circulando com o local da lesão, desta maneira as plaquetas sofrem adesão mais facilmente ao endotélio lesado, sendo este contato fundamental para as plaquetas serem ativadas, assim dando origem há formação do tampão plaquetário (Harger et al, 1983;Rumbaut e Thiagarajan, 2010;Broos et al, 2011;Clemetson, 2012 (Lichtman, 2006;Versteeg et al, 2013).…”

Section: Introductionunclassified

Polimorfismos genéticos relacionados à hemostasia e a sua relação com abortos espontâneos recorrentes

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Etiology of Recurrent Pregnancy Losses and Outcome of Subsequent Pregnancies

Cited by 94 publications

References 0 publications

The prevalence of ureaplasma urealyticum, mycoplasma hominis, chlamydia trachomatis and neisseria gonorrhoeae infections, and the rubella status of patients undergoing an initial infertility evaluation

The prevalence of ureaplasma urealyticum, mycoplasma hominis, chlamydia trachomatis and neisseria gonorrhoeae infections, and the rubella status of patients undergoing an initial infertility evaluation

Gestational prognostic factors in women with recurrent spontaneous abortion

Polimorfismos genéticos relacionados à hemostasia e a sua relação com abortos espontâneos recorrentes

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