Etiology of sinonasal inverted papilloma: An update

Sunkara, Pranit R; Saraswathula, Anirudh; Ramanathan, Murugappan

doi:10.1002/lio2.821

Cited by 8 publications

(9 citation statements)

References 63 publications

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“…3 While its etiology remains undefined, several studies have found a correlation between SNIP and chronic inflammation. 8,9 Furthermore, one study also found an association between occupational exposure and SNIP. 8 However, larger-scale studies are needed to confirm the significance of these findings.…”

Section: Discussionmentioning

confidence: 96%

Endoscopic surgical approach of sinonasal inverted papilloma: A case report and mini review

Dayinta Grahitanindya,

Ida Bagus Gede Hendra Kusuma,

Ida Bagus Semara Putra

et al. 2024

GSC Adv. Res. Rev.

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Sinonasal inverted papilloma (SNIP) is a relatively rare benign tumor that occurs in 0.2-1.5 per 100.000 persons each year, comprising 0.5% - 4% of all sinonasal neoplasms. Despite being benign in nature, SNIP exhibits local aggressiveness due to its distinctive proliferation of metaplastic surface epithelium that undergoes inversion into the underlying stroma. Also, it carries a risk of malignant transformation. These characteristics thus emphasize the necessity for complete surgical excision as the primary treatment. A 50-year-old woman presented with sinonasal inverted papilloma classified as stage T2 according to Krouse staging, suitable for a less invasive endoscopic approach. However, CT scan revealed maxillary sinusitis. Adhering to SNIP management principles, a surgical excision through Endoscopic Sinus Surgery (ESS) followed by Endoscopic Modified Medial Maxillectomy (EMMM) or prelacrimal approach was chosen to provide better visualization of the anterior, lateral, posterior, inferior, and medial walls of the maxillary sinus. This approach aimed to preserve the inferior turbinate and nasolacrimal, avoiding postoperative lacrimation.

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Section: Discussionmentioning

confidence: 96%

Endoscopic surgical approach of sinonasal inverted papilloma: A case report and mini review

Dayinta Grahitanindya,

Ida Bagus Gede Hendra Kusuma,

Ida Bagus Semara Putra

et al. 2024

GSC Adv. Res. Rev.

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“…Inverted papilloma (IP) is an unusual type of benign tumor, accounting for 0.5-4% of nasosinus tumors, 99% of which are unilateral [1][2][3]. It progresses slowly, marked by recurrence, bone lysis and transformation to malignancy [4,5].…”

Section: Introductionmentioning

confidence: 99%

Sinonasal Inverted Papilloma: A Case Report from Mali

Elansari,

Sangare,

Keita

et al. 2024

IJO

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Inverted papilloma (IP) or also called Schneiderian Papilloma is an unusual and rare type of nasal tumor. Generally benign, but can have osteolytic powers and the possibility of transformation into malignancy during its evolution. Several hypotheses emerge in the literature, however the most frequent remains viral origin with the involvement of human papillomavirus (HPV). This is a case of bilateral inverted papilloma in a 60-year-old male patient at the Reference Health Center of the VI commune of the Bamako-Mali district. The symptoms appeared about 14 months ago, marked by a bilateral anterior rhinorrhea, of gradual appearance, associated with nasal obstruction, epistaxis, headaches and anosmia. Thus the diagnosis was made using physical examination and additional examinations such as the scanner of the facial massif, the anatomopathological examination of the operating room, and the test of the human papillomavirus, which turned out to be positive for HPV16 and HPV18. The management consisted of endonasal surgery, with the complete macroscopic removal of the mass and an average meatotomy accompanied by two years of follow-up after the surgical procedure. Since the PI is an aggressive tumor, its management must require long-term surveillance due to the possibility of recidivism and malignant degeneration finally to act early for these eventualities.

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“…VEGF and epidermal growth factor receptor (EGFR) (exon 20 mutations) have also both been implicated in the development of SNIP [12]. Additional data have shown the upregulation of speci c genes in SNIP samples with carcinoma or carcinoma-in-situ when compared to SNIP without dysplasia [11].…”

Section: Introductionmentioning

confidence: 99%

“…One recent study suggested the potential role of chronic in ammation [6,7] and viral (human papillomavirus and Epstein-Barr virus) infection in the etiology of SNIP [8][9][10]. At the molecular level, several cell cycle and angiogenic factors, such as Ki67, vascular endothelial growth factor (VEGF), and Akt/mTOR have been implicated in the development and progression of SNIP [11]. VEGF and epidermal growth factor receptor (EGFR) (exon 20 mutations) have also both been implicated in the development of SNIP [12].…”

Section: Introductionmentioning

confidence: 99%

Identification and Potential Value of Candidate Genes in Patients with Sinonasal inverted papilloma

Chen

2023

Preprint

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Background: This study aimed to explore candidate genes involved in the pathogenesis of sinonasal inverted papilloma (SNIP) using bioinformatic analysis and experimental verification. Methods: For this, gene expression profiles (GSE193016) were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified, with Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) being used to analyze the functions and pathways of DEGs. Co-expression networks were established using single-sample gene set enrichment analysis (GSEA). Furthermore, Search Tool for the Retrieval of Interacting Genes (STRING), Cytoscape, Molecular Complex Detection (MCODE), and Cytohubba were used to construct protein–protein interaction (PPI) networks, screen hub DEGs, and identify hub genes, with a miRNA-TF-hub gene regulatory network also being constructed. Finally, expression levels of identified hub genes were verified using RT-qPCR. Results: As a result, 985 DEGs were identified, including 343 upregulated and 642 downregulated genes. Functional enrichment analyses showed that upregulated DEGs were significantly enriched in epidermal development, cornification, keratinocyte differentiation, epidermal cell differentiation, and skin development. Meanwhile, downregulated DEGs were significantly enriched in muscle contraction, extracellular structure organization, muscle system process, extracellular matrix organization, and regulation of membrane potential. The top eight hub genes were MAD2L1, CDC20, CCNB2, CCNB1, AURKB, NDC80, KIF11, and DLGAP5. During the validation stage, the expression of MAD2L1 was significantly higher in patients with SNIP than in those with normal nasal mucosa. Conclusions: Overall, this study identified key genes associated with SNIP and their biological functions. Furthermore, a variety of predicted genes involved in the cell cycle were found to be connected to SNIP pathogenesis and malignant transformation. MAD2L1may play an important role in SNIP pathogenesis, providing novel insights into the occurrence and development of SNIP.

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Etiology of sinonasal inverted papilloma: An update

Cited by 8 publications

References 63 publications

Endoscopic surgical approach of sinonasal inverted papilloma: A case report and mini review

Endoscopic surgical approach of sinonasal inverted papilloma: A case report and mini review

Sinonasal Inverted Papilloma: A Case Report from Mali

Identification and Potential Value of Candidate Genes in Patients with Sinonasal inverted papilloma

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