Etiology of sinonasal inverted papilloma: A narrative review

Wang, Mingjie; Noel, Julia E.

doi:10.1016/j.wjorl.2016.11.004

Cited by 83 publications

(91 citation statements)

References 36 publications

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“…5,7 In addition, Yoon et al 7 found that 21.9% of IPs were immediately adjacent to inflammatory polyps suggesting that chronic inflammation is associated with IP. 8 Orlandi et al 6 found that patients with IP tended to have higher Lund-Mackay scores on the contralateral side; however, this was not found to be statistically significant.…”

Section: Discussionmentioning

confidence: 96%

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Inverted papilloma is associated with greater radiographic inflammatory disease than other sinonasal malignancy

Papagiannopoulos

Tong

Kuan

et al. 2020

Int Forum Allergy Rhinol

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Background The pathogenesis of inverted papilloma (IP) has not been fully elucidated. However, chronic paranasal sinus inflammation has been anecdotally observed in sites distant from tumor obstruction in IP patients, suggesting an association between inflammation and IP tumorigenesis. This study assesses the association between sinonasal inflammation found in IP and compares this to the level of inflammation observed in other sinonasal tumors. Methods A retrospective chart review was performed identifying patients with unilateral IP. Pertinent clinical data was obtained and comparative analysis of preoperative computed tomography (CT) imaging and histopathology was performed. A sample of unilateral, sinonasal, non‐IP and non–squamous cell tumors was used as the control. The Lund‐Mackay scoring system was used to assess radiologic sinonasal inflammation both ipsilateral and contralateral to the tumor. Results Seventy‐one patients were included; 58.9% of patients with IP had evidence of contralateral sinusitis at the time of presentation. In the control group, 26.7% had evidence of contralateral inflammation. When comparing contralateral sinus inflammation between the 2 study groups, the IP patients had significantly higher Lund‐Mackay scores than the control group (1.9 vs 0.26, p < 0.001). When comparing ipsilateral sinus inflammation, no significant difference was found in Lund‐Mackay scores (5.44 vs 4.00, p < 0.184). Conclusion In this study, unilateral IPs were associated with a higher level of contralateral sinonasal inflammation when compared to control. This suggests that IP may be associated with inflammation that is independent of obstruction by the tumor. Further studies are needed to better understand the temporal relationship between chronic inflammation and tumorigenesis.

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Section: Discussionmentioning

confidence: 96%

“…In addition, Yoon et al . found that 21.9% of IPs were immediately adjacent to inflammatory polyps suggesting that chronic inflammation is associated with IP . Orlandi et al .…”

Section: Discussionmentioning

confidence: 99%

Inverted papilloma is associated with greater radiographic inflammatory disease than other sinonasal malignancy

Papagiannopoulos

Tong

Kuan

et al. 2020

Int Forum Allergy Rhinol

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“…Many authors studied the implication of Human Papilloma Virus (HPV) in the etiology of IP, but the data found in the literature are still contradictory. Different meta-analyses show that HPV rates between 17-38% 10 , 6 and 11 serotypes being associated with the benign form of IP, while 16 and 18 serotypes are related to malignancy [19][20][21][22] . There are also authors who do not sup-port this theory 19,23,24 .…”

Section: Incidence and Etiopathogenesismentioning

confidence: 99%

“…Different meta-analyses show that HPV rates between 17-38% 10 , 6 and 11 serotypes being associated with the benign form of IP, while 16 and 18 serotypes are related to malignancy [19][20][21][22] . There are also authors who do not sup-port this theory 19,23,24 . A recently published study from Mohajeri et al 25 does not support the role the human papilloma virus plays as an etiological factor for disease recurrence or its potential progression to squamous cell carcinoma.…”

Section: Incidence and Etiopathogenesismentioning

confidence: 99%

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Sinonasal inverted papilloma – what’s new

Mârza

Sarafoleanu

Muşat

2019

Romanian Journal of Rhinology

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Inverted or Schneiderian papilloma is a locally aggressive benign tumor with strong recurring tendency and a high potential to transform into a malignant squamous cell carcinoma. Although the clinical characteristics of inverted papilloma, along with the morphological features, have been adequately described, controversy remains with regards to the risk factors and disease etiology. The complete excision of the tumor by surgery is traditionally considered the mainstay of therapy. This paper updates the state of knowledge and presents our experience from treating 52 patients, diagnosed with inverted papilloma, who underwent surgical treatment in our department. We performed genotyping for Human Papilloma Virus (HPV) for all the patients included in our study group.

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Outcomes of sinonasal inverted papilloma resection by surgical approach: an updated systematic review and meta‐analysis

Peng

Thamboo

Choby

et al. 2019

Int Forum Allergy Rhinol

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BackgroundSelecting the optimal surgical approach for resection of sinonasal inverted papilloma (SIP) remains a challenge, with endoscopic, external, and combined approaches being utilized. This systematic review was conducted as an update to a 2006 systematic review to determine the preferred surgical approach for tumor control.MethodsThe study protocol was developed a priori following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) process. Data were collected and outcomes were analyzed according to surgical approach and sites of tumor involvement.ResultsA total of 96 papers and 4134 SIP patients were included. The overall recurrence rate was 12.80% (322/2515) for the endoscopic approach group, 16.58% (182/1098) for the external approach group, and 12.60% (65/516) for the combined approach group. Meta‐analysis by random effects model showed that the summarized risk ratio (RR) of recurrence was 0.61 (95% confidence interval [CI], 0.44 to 0.85, p = 0.003), I2 = 37.95% for the endoscopic vs external approach; 0.98 (95% CI, 0.69 to 1.39, p = 0.901), I2 = 9.06% for the endoscopic vs combined approach; 1.61 (95% CI, 1.06 to 2.43, p = 0.025), I2 = 0.00% for the external vs combined approach. After adjusting for publication bias, the adjusted RRs were 0.66 (p = 0.014) for endoscopic vs external; 0.99 (p = 0.955) for endoscopic vs combined; and 1.33 (p = 0.224) for external vs combined.ConclusionAn enlarging and maturing body of literature continues to indicate that endoscopic approaches result in significantly lower recurrence rates than open approaches for surgical resection of SIP.

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Etiology of sinonasal inverted papilloma: A narrative review

Cited by 83 publications

References 36 publications

Inverted papilloma is associated with greater radiographic inflammatory disease than other sinonasal malignancy

Inverted papilloma is associated with greater radiographic inflammatory disease than other sinonasal malignancy

Sinonasal inverted papilloma – what’s new

Outcomes of sinonasal inverted papilloma resection by surgical approach: an updated systematic review and meta‐analysis

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