Etiopathogenesis and clinical presentation of carotid body tumors

Baysal, Bora E.; Myers, Eugene N.

doi:10.1002/jemt.10200

Cited by 77 publications

(52 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Paraganglionic cells that are the constituent of this structure sense the blood pH; pO2 and pCO2 changes. [3] They are more common in women and in 10% of the patients are seen bilaterally. [4] Only 3-12.5% of them are malignant.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Surgical Treatment of Carotid Body Tumors

Özen¹

2015

Ann Clin Anal Med

View full text Add to dashboard Cite

ÖzetAmaç: Glomus karotikum tümörleri boyun bölgesinin nadir görülen tümörle-rindendir. Cerrrahinin esas amacı tümörün eksize edilip çıkartılmasıdır. Bu ça-lışma; ameliyat edilen hastalardaki cerrahi strateji ve cerrahi sonuçlar üzerine odaklanmıştır. Gereç ve Yöntem: Hastanemizde; 2004-2013 yılları arasında; 10 hasta (ortalama yaş 49±9; 41-69 yaş arası) karotikum tümörü tanısı ile ameliyat edilmiştir. Tanı bilgisayarlı tomografi; manyetik rezonans görüntüle-me veya Doppler ultrasonografiyi takiben yapılan dijital substraction anjiyografi ile konulmuştur. Shamblin sınıflandırmasına gore 2 hasta tip 3 ve 8 hasta da tip 2 olarak değerlendirilmiştir. Bulgular: Cerrahi sonrası mortalite gözlen-medi. Ameliyat sonrasında hastalarda nörolojik sekel görülmedi. Takip süre-si 44.11±34.62 ay(dağılım 2-98 ay) olarak saptandı. Ses kısıklığı postoperatif dönemde bir hastada meydana gelmiş olup ameliyat sonrası 2. ayda kaybolmuştur. 2 hastada preoperatif dönemde mevcut olan dilde deviyasyon ve sağ gözdeki pitozis ameliyat sonrasında da devam etti. 1 hastada ses kısık-lığı ve disfaji devam etti. 2 hasta tümör rekürensi nedeni ile tekrar ameliyat edildi. Sonuç: Glomus karotikum tümörlerinin tedavisinde en iyi yöntem cerrahidir. Arteriyal yapıların devamlılığının korunması ve cerrahi sırasında komşu vasküler ve sinir yapıların hasar görmemesi için azami dikkat gerekmektedir. Anahtar KelimelerKarotis Cisim Tümörü; Paraganglioma; Glomus Karotikum Tümörü; Karotis Arteri Abstract Aim: Carotid body tumors are rare benign tumors of the neck. Excision of the tumor is the main goal of the surgical procedure. This study is focused on the surgical strategy and results of the patients who were operated for carotid body tumor. Material and Method: 10 patients with a mean age 49±9 years; ranging from 41-69 years with carotid body tumor underwent operation in our hospital between 2004-2013. Diagnosis was made using computerized tomography; magnetic resonance imaging or digital substraction angiography after the initial doppler ultrasonography. According to Shamblin classification; 2 patients have type 3 and 8 patients have type 2 carotid body tumors. Results: There was no postoperative mortality. There were no neurologic sequelae after the operation. The follow-up period was 44.11± 34.62 months (range 2-98 months). Hoarseness developed in one patient postoperatively and it disappeared 2 months after the operation. Two patients with deviation of the tongue and pytosis of the right eyelid had the same symptoms after the operation. In one patient; hoarseness and dysphagia had continued. Reoperations were done due to recurrence of the tumor in two (20%) patients. Discussion: Surgical excision is the best treatment modality for glomus caroticum tumors. Arterial continuity should be maintained and special attention should be made to avoid damaging adjacent vascular and neural structures during dissection.

show abstract

Section: Discussionmentioning

confidence: 99%

Diagnosis and Surgical Treatment of Carotid Body Tumors

Özen¹

2015

Ann Clin Anal Med

View full text Add to dashboard Cite

show abstract

“…Paraganglionic cells constituting this body sense pH, pO2 and pCO2 changes in the blood [1]. While the size of the body may vary, the mean size is 5 9 3 9 1.5 mm.…”

Section: Discussionmentioning

confidence: 99%

Carotid Body Tumors and Our Surgical Approaches

Şanlı

Öz

Ayduran

et al. 2012

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Glomus tumors known as paragangliomas are neoplasms arising from the neural crest. They are named according to the place they originate from. Tumors originating from the carotid body at the carotid bifurcation are called Carotid Body Tumors (CBT). Surgical intervention is planned according to the Shamblin classification. 17 patients were operated after being diagnosed with CBT in our clinic between February 2007 and June 2010. 12 (70.5%) of the patients were male, and 5 (29.4%) of the patients were female. The average age was 42 (ages ranging between 32 and 47). Nine of the patients were diagnosed and treated with Shamblin type I tumor, seven of the patients with type II and one patient with type III. Only one patient had bilateral carotid tumor. In all patients with Shamblin type I and II, blunt dissection of the tumor was conducted smoothly by means of thermal cautery in the subadventitial plane. The patient with Shamblin type III had tumor invasion in the carotid artery and adjacent tissues were in an adherent state. Therefore mass resection was carried out by resecting 2 cm of the distal portion of the common carotid artery and 3 cm of the proximal portion of the internal carotid artery. 6 mm of synthetic polytetrafluoroethylene graft was interpositioned between the common carotid artery and the internal carotid artery. External carotid artery was anastomosed to this graft in an end-to-end fashion. The patient developed vocal cord paralysis postoperatively on the lesion side. The patient who underwent bilateral tumor excision developed Baroreflex Failure Syndrome. In the two patients thrombus developed in the internal carotid artery in the early postoperative period. These patients underwent thrombectomy and developed hemiplegia on the lesion side. One of them died on the seventh post-operative day while in follow-up in the intensive care unit. Surgical resection is the recommended treatment for carotid body tumors. Shamblin I and II type tumors' dimensions and pathological characteristics allow dissection. However Shamblin III tumors may require carotid artery resection and reconstruction due to tissue invasion. The possibility of post-operative cranial nerve paralysis and arterial thrombosis should be taken into account.

show abstract

“…Özellikle genç hastalarda uzun vadede malign transformasyon ve radyasyona bağlı sekonder malignite gelişme riskleri mevcuttur. 19 Bu nedenle genç hastalarda cerrahi tercih edilmelidir.…”

Section: Discussionunclassified