Etiopathogenesis of acquired cholesteatoma: Prominent theories and recent advances in biomolecular research

Kuo, Chin‐Lung

doi:10.1002/lary.24890

Cited by 134 publications

(145 citation statements)

References 76 publications

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“…The annual incidence of cholesteatoma is greatly variable being dependent on plenty of factors including environmental, socioeconomic, ethnic, genetic, anatomical, and physiological ones [6]. Broadly speaking, it ranges from 9 to 12.6 per 100,000 in adults and 3 to 15 per 100,000 in children with male predominance [1,4,6]. Caucasian people show the highest prevalence (12.6 per 100,000) followed by Africans whilst the lowest prevalence is seen among Eskimos, possibly due to larger nasopharynx and wider auditory tube [1,4].…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Hamed

Nakata

Sayed

et al. 2016

Clin Exp Otorhinolaryngol

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Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords ‘aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines.’ In order to strengthen our study, we searched the reference lists of identified reviews. Cholesteatoma is a subject of debate among otolaryngologists since it was prescribed firstly. Over many decades, several theories were postulated for aetiopathogenesis of cholesteatoma with a tendency to follow more than one theory to explain the proper nature of that disease. Until now, the mechanism of bone resorption has yet to be more clarified. In the last century, a leap has occurred in the field of biomolecular cholesteatoma research which improved our knowledge about its pathophysiology and bone destructive mechanism. However, surgery is still the only available treatment. We conclude that discovery of new therapeutic choices for cholesteatoma other than surgery by the use of anti-growth, anti-proliferative, apoptotic agents as well as medications that antagonize osteoclastogenesis should be the main concern in the future clinical and experimental research work. Also, searching for predictors of the aggressiveness of cholesteatoma can affect the timing of intervention and prevent occurrence of complications.

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Section: Introductionmentioning

confidence: 99%

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Hamed

Nakata

Sayed

et al. 2016

Clin Exp Otorhinolaryngol

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“…Grommet insertion has been reported to be an iatrogenic cause of secondary acquired cholesteatoma [81][82][83][84][85][86]. The development of the disease is quite uncommon, with a reported rate of approximately 1% in non-CLP children with VTI [73,87].…”

Section: Cholesteatomamentioning

confidence: 99%

Tympanostomy Tube Placement for Otitis Media with Effusion in Children with Cleft Lip and Palate

Kuo¹,

Shiao²

2017

Designing Strategies for Cleft Lip and Palate Care

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The condition of cleft lip/palate (CLP) in children is psychologically stressful for family members and debilitating for the patients themselves. These children must undergo a series of major invasive surgeries following birth, including cleft lip repair surgery, cleft palate repair surgery, bone grafting surgery, and dental implant surgery. Unfortunately, the clinical significance of otitis media with effusion (OME), a complication associated with CLP, is often overlooked, and very few studies have explored this condition in depth. This chapter reviews pathogenesis, clinical manifestations, consequences, examination, and diagnosis related to OME in children with CLP. Controversies surrounding the treatment of OME in CLP children are also discussed. We also provide a flowchart for management guidance in OME in children with CLP.

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“…Thus, some clinicians view VTI as the most viable treatment modality. Nevertheless, VTI can have several adverse effects, such as secondary acquired cholesteatoma or infectious otorrhea (incidence rate of 29% to 64%), which is the most common complication following tube placement and is often refractory to local or medical treatment [5,[8][9][10][11]. In summary, no effective strategies for the management of otologic symptoms based on conventional approaches have been developed.…”

Section: Conventional Management Options and Limited Therapeutic Effectsmentioning

confidence: 99%

Strategies for the Management of Post-Irradiation Otitis Media with Effusion

Shiao¹

2015

J Oto Rec Surg

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Etiopathogenesis of acquired cholesteatoma: Prominent theories and recent advances in biomolecular research

Abstract: This article summarizes the existing theories and provides conceptual insights into the etiopathogenesis of acquired cholesteatoma, with the aim of stimulating continued efforts to develop a nonsurgical means of treating the disorder.

Cited by 134 publications

References 76 publications

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Tympanostomy Tube Placement for Otitis Media with Effusion in Children with Cleft Lip and Palate

Strategies for the Management of Post-Irradiation Otitis Media with Effusion

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