Etiopathogenesis of otosclerosis

Karosi, Tamás; Sziklai, István

doi:10.1007/s00405-010-1292-1

Cited by 54 publications

(51 citation statements)

References 87 publications

(154 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1][2][3][4][5] A prevalência da otosclerose clínica, ou seja, sintomática, está estimada entre os 0,04% e 1% (média 0,3%) nos caucasianos, 6,13 enquanto nos asiáticos a prevalência é mais baixa 14 e, na raça negra, praticamente nula, com algumas exceções já descritas. 7,15 Por outro lado, a otosclerose histológica é considerada mais frequente, alcançando prevalências de 10% nos caucasianos, 5% nos asiáticos e 1% nos africanos, em estudos realizados nos Estados Unidos.…”

Section: Discussionunclassified

“…2,3 Atualmente considera-se a otosclerose como uma Clinicamente, os doentes apresentam uma hipoacusia progressiva de condução, mista ou neurossensorial, que surge com frequência por volta da terceira à quinta déca-da de vida.…”

unclassified

“…[2][3][4][5] Em estudos epidemiológicos, tanto a otosclerose clínica como a otosclerose histológica (detetada em exame histológico e independente da presença de sintomas clínicos) aparecem menos frequentemente na raça negra. [2][3][4][5] No entanto, após revisão bibliográfica, encontram-se poucos trabalhos sobre a otosclerose em África, 7 sendo este, tanto quanto é do conhecimento dos autores, o primeiro estudo sobre a otosclerose em São Tomé e Príncipe (STP).…”

unclassified

See 2 more Smart Citations

Anquilose Estapedo-Vestibular: Estudo Retrospetivo de Cinco Casos em São Tomé e Príncipe

Campelo¹,

Caroça²,

Tinoco³

et al. 2017

Acta Med Port

View full text Add to dashboard Cite

Introduction: Otosclerosis is a common form of conductive hearing loss characterized by abnormal bone remodeling exclusively in the otic capsule. The prevalence of otosclerosis varies in racial populations and is described as being rare in black African populations. In this paper we aim to report five cases of clinical, and surgically confirmed, otosclerosis in black individuals, in São Tomé and Príncipe.Material and Methods: Since February 2011, Ear, Nose and Throat consultations and surgeries specialty have been carried out at Dr. Ayres de Menezes Hospital in cooperation with the project ‘Health for all’. A retrospective analysis was undertaken of the records of all patients subjected either to stapedectomy or partial stapedectomy until February 2014. Information regarding clinical presentation, audiometric data and surgery reports was recorded.Results: Five adult patients underwent stapedectomy or partial stapedectomy. All of them presented with normal otoscopy, conductive or mixed hearing loss on audiogram and normal tympanometry with absent stapedial reflexes. None of the patients had signs of infection or history of head trauma. Three cases showed improvement in the air-bone gap after surgery. The other two were lost to follow-up.Discussion: We documented and surgically confirmed five cases of clinical otosclerosis in this population. A thematic review was carried out and concluded that, despite being described as a rare event in this race, available literature on this topic is not enough to state that there is lower prevalence of otosclerosis amongst the African population.Conclusion: Even if not common, otosclerosis cannot be disregarded as a possible cause for conductive hearing loss among the population of São Tomé and Principe.

show abstract

Section: Discussionunclassified

unclassified

See 1 more Smart Citation

Anquilose Estapedo-Vestibular: Estudo Retrospetivo de Cinco Casos em São Tomé e Príncipe

Campelo¹,

Caroça²,

Tinoco³

et al. 2017

Acta Med Port

View full text Add to dashboard Cite

show abstract

“…The cause of otosclerosis is still unknown (6). Etiopathogenesis of otosclerosis was based of histopathological analysis of the removed stapes footplate in earlier researches, but nowadays all researches are based on molecular biology of otosclerosis (13).…”

Section: Discussionmentioning

confidence: 99%

Avascular Necrosis of Stapes Crura in One Case of Operated Otosclerosis

Erdoglija

Sotirović

Jacimovic

et al. 2012

Acta Med. (Hradec Kralove, Czech Repub.)

View full text Add to dashboard Cite

Summary: Unilateral otosclerosis combined with avascular necrosis of stapes crura is a rare entity. it should be considered in a case of high grade otosclerosis. Symptoms are the same as in patients who suffer from common otosclerosis. Patients complain on progressive hearing loss and tinnitus. The diagnosis is made clinically by conventional audiologic evaluation and radiologically by x-ray mastoid Schuller's view and CT scan. HRCT scan makes visible all parts of ossicular chain and gives surgeon some information about ossicular chain damage. Surgery with stapedotomy and stapes prosthesis implantation in a case of otosclerosis with avascular necrosis of stapes crura can be success therapy to improve patient's hearing

show abstract

“…The etiopathogenesis of otosclerosis is a subject of continuous research and it has been proposed to be dependent on viral, genetic, inflammatory, autoimmune, environmental, hormonal, and metabolic factors [1][2][3]. However, these theories failed to predict the laterality of the ear that will be first affected by the disease and are out of the focus of current investigation.…”

Section: Introductionmentioning

confidence: 94%

In search of correlation between hand preference and laterality of hearing impairment in patients with otosclerosis

Migirov

Wolf

2014

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

The aim of this study was to investigate a possible correlation between handedness and laterality of hearing impairment due to otosclerosis. All patients operated for otosclerosis between August 2008 and February 2014 were queried about their handedness. The study group consisted of 218 right-handed and 21 left-handed (8.9%) patients [139 female (58.2%) and 100 male] with an age range of 18-75 years (mean 46.1 years). One-hundred and fifty-seven patients had a bilateral otosclerosis (BO) and 82 (34.3%) had a unilateral otosclerosis (UO). There were 11 left-handed male and 10 left-handed female (11% vs. 7.2 %, p = 0.305). In patients with UO, the left ear (LE) was affected in 6/11 (58.3%) left handed ones, and the right ear (RE) in 41/71 (57.7%) right handed ones (p = 0.842). In patients with BO, the LE was more affected in the left-handed ones, and the RE in the right-handed ones (7/10, 70% and 87/147, 59.2 %, respectively, p = 0.5). Overall, 13/21 (61.9%) left-handed patients presented with only/mostly left-sided otosclerosis, while 128/218 (58.7%) right-handed patients presented with only/mostly right-sided otosclerosis (p = 0.584). Clinical relevance of presented findings is unclear yet nevertheless current study may contribute one more element in the multifactorial process of otosclerosis-related hearing loss.

show abstract

Etiopathogenesis of otosclerosis

Cited by 54 publications

References 87 publications

Anquilose Estapedo-Vestibular: Estudo Retrospetivo de Cinco Casos em São Tomé e Príncipe

Anquilose Estapedo-Vestibular: Estudo Retrospetivo de Cinco Casos em São Tomé e Príncipe

Avascular Necrosis of Stapes Crura in One Case of Operated Otosclerosis

In search of correlation between hand preference and laterality of hearing impairment in patients with otosclerosis

Contact Info

Product

Resources

About