2013
DOI: 10.1007/s00005-013-0261-y
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Etiopathogenesis of Recurrent Aphthous Stomatitis and the Role of Immunologic Aspects: Literature Review

Abstract: Recurrent aphthous stomatitis (RAS; recurrent aphthous ulcers; canker sores) belongs to the group of chronic, inflammatory, ulcerative diseases of the oral mucosa. Up to now, the etiopathogenesis of this condition remains unclear; it is, however, considered to be multifactorial. The results of currently performed studies indicate that genetically mediated disturbances of the innate and acquired immunity play an important role in the disease development. Factors that modify the immunologic response in RAS inclu… Show more

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Cited by 220 publications
(239 citation statements)
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References 110 publications
(165 reference statements)
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“…ecurrent aphthous stomatitis (RAS) belongs to the group of chronic inflammatory diseases of the oral mucosa. 1 Although multiple factor such as genetic, trauma, emotional stress, diet, microbial agents, nutritional, hematological defects, hormonal changes, medications, and atopy are implicated in the etiology of RAS, no definitive consensus was found yet. [2][3][4][5] The role of type IV hypersensitivity in the etiology of RAS can be explained by the elevated levels of CD8 cytotoxic T cells in the histopathology of the ulcerative stage.…”
Section: Evaluation Of Skin Patch Test Results and Allergen Eliminatimentioning
confidence: 99%
“…ecurrent aphthous stomatitis (RAS) belongs to the group of chronic inflammatory diseases of the oral mucosa. 1 Although multiple factor such as genetic, trauma, emotional stress, diet, microbial agents, nutritional, hematological defects, hormonal changes, medications, and atopy are implicated in the etiology of RAS, no definitive consensus was found yet. [2][3][4][5] The role of type IV hypersensitivity in the etiology of RAS can be explained by the elevated levels of CD8 cytotoxic T cells in the histopathology of the ulcerative stage.…”
Section: Evaluation Of Skin Patch Test Results and Allergen Eliminatimentioning
confidence: 99%
“…The aim of treatment is to provide pain control, speed up healing and reduce the incidence of recurrence. [15] Biopsies taken from RAS patients have found the presence of T cells and polymorphonuclear leukocytes in lesions, leading to the consideration that these cells play a role in pathogenesis. [16] Additionally in Behçet''s disease, with similar etiopathogenesis to RAS, hypersensitivity of T lymphocytes to a variety of antigens was not identified, with increased platelet and neutrophil activity was shown in blood parameters.…”
Section: Discussionmentioning
confidence: 99%
“…Key words: Recurrent aphthous stomatitis, oral ulcers, treatment sigara bırakma, kimyasal maddeler ve mikrobiyal ajanlar predispozan olarak düşünülür. Ancak bu multifaktöriyel etiyopatogenez halen tam olarak anlaşılamamıştır [5][6][7][8][9] . İnterlökinlerin (IL-1B, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12), interferon (IFN-γ) ve tümör nekroz faktörün (TNF-α) metabolizmasındaki değişikliklerle ortaya çıkması, hastalığın sık görüldüğü bireylerin çocuklarında da bu ülsere lezyonların oluşması ve ikizlerde yapılan çalışmalarda yatkınlık tespit edilmesi, çevresel etkenlerle birlikte genetik faktörlerin de etiyolojide etkili olduğunu göstermiştir 10,11 .…”
Section: Introductionunclassified
“…Minör formu gibi lezyonların iki hafta içinde iyileşmesi beklenir. Şekli nedeniyle Herpes lezyonlarından ayırt edilmesi gerekir 4,6,20,23 . RAS, tek başına ortaya çıkabildiği gibi çeşitli sistemik hastalıkların bir parçası olarak da oluşabilir.…”
Section: Introductionunclassified
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