The aim of this article is to describe and analyze the arguments against vaccination for covid-19 put forward by groups of people in the socio-digital network Telegram between June 28 and July 1 of 2021. More specifically, it is proposed to identify the plurality of arguments of those people who opposed the vaccination system, with its nuances and differences. Moreover, it investigates the logics of reasonableness and legitimacy that underline them. We use the methodological approaches of the sociosemiotics and sociolinguistics to describe the interpretative model of those who was against vaccination, through the analysis if the discursive marks. As we saw during 2020 and 2021, the effective actions against the pandemic would not be enough if we do not have the consensus with all the social actor, including those who are against the scientific discourses of the State.