1994
DOI: 10.1007/bf00684867
|View full text |Cite
|
Sign up to set email alerts
|

Etoposide dosage and pharmacodynamics

Abstract: Etoposide is a schedule-dependent cytotoxic drug with high single agent activity in small-cell lung cancer and lymphoma. Despite its clear dose-dependent myelosuppressive activity, dose-dependent evidence of its anti-tumour activity is harder to demonstrate. A number of reports have correlated haematological toxicity with pharmacokinetic and physiological parameters, which explains some of the variability in dynamic effects that exists between patients. Recent reports have also suggested that anti-tumour respo… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
10
0

Year Published

2000
2000
2018
2018

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 49 publications
(10 citation statements)
references
References 14 publications
0
10
0
Order By: Relevance
“…These results suggest that test components used in this study might interfere with the growth of EAT cells by activation of macrophages and neutrophils. The functional activity of neutrophils and/or macrophages are related to the amount of reactive oxygen species (ROS) produced during the respiratory burst after their activation [34,35]. The ROS production in activated neutrophils seems to influence their lifespan which in turn can be modulated by antioxidants [36].…”
Section: Discussionmentioning
confidence: 99%
“…These results suggest that test components used in this study might interfere with the growth of EAT cells by activation of macrophages and neutrophils. The functional activity of neutrophils and/or macrophages are related to the amount of reactive oxygen species (ROS) produced during the respiratory burst after their activation [34,35]. The ROS production in activated neutrophils seems to influence their lifespan which in turn can be modulated by antioxidants [36].…”
Section: Discussionmentioning
confidence: 99%
“…It is not at all clear which independent risk factors best predict drug toxicity. While there are often limited data, etoposide, for example, has shown a correlation between age and toxicity [62]. Age is an important predictor of metabolic capacity [63], although perhaps not as powerful as major gender differences in metabolism or functional polymorphisms, as is seen with 5-fluorouracil [64].…”
Section: Functional Status Comorbidity and Toxicitymentioning
confidence: 99%
“…8,9 Aside from pharmacokinetics, etoposide is poorly soluble in aqueous solutions necessitating slow infusion over 30-60 min and requires solubilizing agents such as surfactants and alcohols. 10 The encapsulation of poorly soluble drugs in nanoparticles can enhance the therapeutic index and pharmacokinetics of cytotoxic treatments. 11 These nanotherapeutics are made from organic or inorganic materials, typically 10-200 nm in diameter, and can be produced in a variety of formulations and configurations that improve the delivery or protection of the therapeutic agents.…”
Section: Introductionmentioning
confidence: 99%