2023
DOI: 10.21203/rs.3.rs-2522083/v1
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Etoposide/platinum plus anlotinib for patients with transformed small-cell lung cancer from EGFR-mutant lung adenocarcinoma after EGFR-TKI resistance: A retrospective and observational study

Abstract: Objective: The histological conversion of lung adenocarcinoma (LUAD) into small-cell lung cancer (SCLC) is an important resistance mechanism for epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-resistant LUAD. Anlotinib has been recommended as the third-line treatment for SCLC patients. The efficacy of etoposide/platinum (EP) as the main treatment is very limited for patients with transformed SCLC. However, little is known about EP plus anlotinib for transformed SCLC. The present study r… Show more

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“…Initially, individuals who had previously undergone targeted therapy were eligible if they had a known sensitising EGFR mutation or ALK translocation. Following that, the study design was changed to remove these patients (7 patients) from the analysis due to emerging evidence suggesting that chemotherapy in combination with platinum after, or in combination with TKI may be beneficial for them [ [21] , [22] , [23] , [24] ]. At the time of screening, all patients were assessed for central nervous system (CNS) metastases, liver metastases, adrenal metastases, and bone metastases using computed tomography with contrast, magnetic resonance imaging with contrast if indicated, or both, depending on the presented symptoms.…”
Section: Methodsmentioning
confidence: 99%
“…Initially, individuals who had previously undergone targeted therapy were eligible if they had a known sensitising EGFR mutation or ALK translocation. Following that, the study design was changed to remove these patients (7 patients) from the analysis due to emerging evidence suggesting that chemotherapy in combination with platinum after, or in combination with TKI may be beneficial for them [ [21] , [22] , [23] , [24] ]. At the time of screening, all patients were assessed for central nervous system (CNS) metastases, liver metastases, adrenal metastases, and bone metastases using computed tomography with contrast, magnetic resonance imaging with contrast if indicated, or both, depending on the presented symptoms.…”
Section: Methodsmentioning
confidence: 99%