Etretinate and Skin Cancer Prevention

Verret, J L; Schnitzler, L; Avenel, M; Smulevici, A

doi:10.1159/000429424

Cited by 7 publications

(5 citation statements)

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“…This finding has previously been reported in 1 patient [12] and a similar response to etretinate was reported in the non-rclated condition of multiple keratoacanthomata [13]. Etretinate normalizes keratinization and may prevent squamous cell metaplasia by the modulation of epidermal differentia tion [14].…”

Section: Discussionsupporting

confidence: 86%

Self-Healing Epitheliomata of Ferguson-Smith: Cytogenetic and Histological Studies, and the Therapeutic Effect of Etretinate

Wright

Gawkrodger²,

Branford³

et al. 1988

Dermatology

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212 epitheliomata developed in two unrelated women with self-healing epitheliomata of Ferguson-Smith. Most of the lesions appear on the face, often in crops; they enlarge over 4 weeks and, without treatment, resolve over 4 months to leave a ragged scar. One of the patients developed an unusual syringoma, a papillary carcinoma of the thyroid and a mucosal squamous cell carcinoma which failed to involute spontaneously. Cytogenetic studies did not reveal any abnormality of DNA repair. Surgical excision of the epitheliomata is successful but time consuming. X-irradiation should not be used, but cryotherapy of early lesions is helpful. One patient, treated with etretinate for 24 months, has developed only 8 epitheliomata over this time, compared with 23 in the previous 24 months. Etretinate therefore appears to prevent new lesions from developing.

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Section: Discussionsupporting

confidence: 86%

Self-Healing Epitheliomata of Ferguson-Smith: Cytogenetic and Histological Studies, and the Therapeutic Effect of Etretinate

Wright

Gawkrodger²,

Branford³

et al. 1988

Dermatology

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“…Similar results have been recorded earlier. 7 , 13 , 14 Finkelstein et al . 15 have recently reported the successful treatment of multiple SCC with low‐dose etretinate therapy in a patient with XP variant.…”

Section: Discussionmentioning

confidence: 99%

Xeroderma pigmentosum in Libya

et al. 1999

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“…Eye protection with artificial tears and soft contact lenses is very useful. Different treatment modalities like topical 5-fluorouracil, [5][6][7] oral retinoids, [5][6][7][8] chemical peeling, dermabrasion [9] and excision with grafting [10] have been tried for premalignant or malignant lesions, [10] more or less successfully.…”

Section: Discussionmentioning

confidence: 99%

“…The lesion was excised keeping 0.7 cm of safe margin. The defect was closed primarily[Figures 6,[7][8][9].…”

mentioning

confidence: 99%

Squamous cell carcinoma of lower lip in very young brothers of xeroderma pigmentosa

Saraiya

Trivedi

Patel

et al. 2007

Indian J Plast Surg

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ABSTRACTa nine-year-old xeroderma pigmentosa (xp) child presented with a non-healing ulcer on the right side of the lower lip. on histological examination the lesion proved to be squamous cell carcinoma. wide excision was done. the excision included lip, buccal mucosa with mucocutaneous junction and only the upper portion of the orbicularis oris muscle. the lip was reconstructed with superiorly based nasolabial flap. recently, his younger brother, who is also suffering from xp developed squamous cell carcinoma of lower lip, and presented to us. wide excision of the lesion was done. the defect was closed primarily. the patient and his brother both have been advised to protect themselves from uv radiation. both are being kept under intense surveillance. ten months of follow-up of the elder brother showed satisfactory, good-looking lip with no sign of recurrence at the local site or at the neck.

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Etretinate and Skin Cancer Prevention

Cited by 7 publications

References 0 publications

Self-Healing Epitheliomata of Ferguson-Smith: Cytogenetic and Histological Studies, and the Therapeutic Effect of Etretinate

Self-Healing Epitheliomata of Ferguson-Smith: Cytogenetic and Histological Studies, and the Therapeutic Effect of Etretinate

Xeroderma pigmentosum in Libya

Squamous cell carcinoma of lower lip in very young brothers of xeroderma pigmentosa

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