Etretinate in pustular psoriasis of plams and soles

Abstract

In a double-blind controlled study of patients with pustular psoriasis of palms and soles who were allocated at random to etretinate or placebo, we found that etretinate improved the condition as assessed by pustule count and overall clinical response. Side-effects occurred but were accepted by the patients in the short-term. The clinical usefulness of etretinate in this condition will depend on time to relapse, and whether this can be prevented or postponed by continuous treatment. Toxicity in the long-term will also be important.

Efficacy and safety of oral retinoids in different psoriasis subtypes: a systematic literature review

“…Single agent: Retinoid has proven to be more effective than placebo in patients with palmoplantar pustular psoriasis 13,47 . In the study of Foged et al.…”

Palmoplantar psoriasis: A phenotypical and clinical review with introduction of a new quality-of-life assessment tool

“…Outside of intense topical therapy (with or without occlusion), phototherapy, and psoralen plus ultraviolet A, oral retinoids have traditionally been the first drug of choice for patients except girls and women of childbearing potential. 56,57 PPP is also reported to clear with many other nontraditional therapies including tonsillectomy 58 and ileojejunal bypass for obesity. 59 With the rapid expansion of biologic medications to treat chronic plaque psoriasis, it is imperative to have better tools to evaluate the clinical effectiveness of these and traditional systemic agents (retinoids, methotrexate, and cyclosporine) in patients with palm and sole involvement and quality-of-life decrements regardless of BSA.…”

TNF receptor I on human keratinocytes is a binding partner for staphylococcal protein A resulting in the activation of NF kappa B, AP-1, and downstream gene transcription

“…Interestingly, one of the major virulence factors of S. aureus staphylococcal protein A (SpA) has previously been analysed concerning its role for the activation of keratinocytes and skin inflammation (14)(15)(16)(17); however, data on the responsible receptors and signal transduction in human keratinocytes are missing. As all S. aureus isolates are endowed with the capacity to produce SpA in their cell walls and secrete this protein to various extent, it was of interest by which receptor SpA activates human keratinocytes and if its production would correlate with disease scores in AE.…”