ETS transcription factors: Multifaceted players from cancer progression to tumor immunity

Wang, Yufei; Huang, Zhao; Sun, Mengyu; Huang, Wenjie; Xia, Limin

doi:10.1016/j.bbcan.2023.188872

Cited by 8 publications

(1 citation statement)

References 220 publications

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“…ETS TFs comprise a large family with 28 members in humans. 51 ETS factors regulate house-keeping genes in a number of cell types. 52,53 Further, they can bind redundantly to regulate house-keeping genes and genes that are constitutively expressed at high levels.…”

Section: Resultsmentioning

confidence: 99%

Rapid profiling of transcription factor-cofactor interaction networks reveals principles of epigenetic regulation

Inge,

Miller,

Hook

et al. 2024

Preprint

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Transcription factor (TF)-cofactor (COF) interactions define dynamic, cell-specific networks that govern gene expression; however, these networks are understudied due to a lack of methods for high-throughput profiling of DNA-bound TF-COF complexes. Here we describe the Cofactor Recruitment (CoRec) method for rapid profiling of cell-specific TF-COF complexes. We define a lysine acetyltransferase (KAT)-TF network in resting and stimulated T cells. We find promiscuous recruitment of KATs for many TFs and that 35% of KAT-TF interactions are condition specific. KAT-TF interactions identify NF-kB as a primary regulator of acutely induced H3K27ac. Finally, we find that heterotypic clustering of CBP/P300-recruiting TFs is a strong predictor of total promoter H3K27ac. Our data supports clustering of TF sites that broadly recruit KATs as a mechanism for widespread co-occurring histone acetylation marks. CoRec can be readily applied to different cell systems and provides a powerful approach to define TF-COF networks impacting chromatin state and gene regulation.

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Section: Resultsmentioning

confidence: 99%