Étude cinétique de l'hydrolyse des amides. XVII. Constantes de vitesse d'hydrolyse acide d'amides aromatiques

Abstract

In order to describe very accurately the reaction scheme of the acidic hydrolysis of amides (B) it is necessary to determine the value of the acidity constant (pKBH+) of the conjugated amidonium ion. Connected with previous investigations in this area, following groups were examined along this line : a first one, R— CO— NH— C6H5— Y involving two different series (R = CH3— and C2H5— ) and for each one, Y = CH30-, CHS-, H— , Cl-, CH3CO-, N02-. A second one pertains to X— C6H4— CO— NH— C6H4— Y and is developed along five different series varying X (X = CH30— , CH3— , H— , Cl—, N02— ) and Y (Y = CH30-, CH3-, H-, Cl-, N02-). Acidity functions, H0 and HA were used for that purpose and new values of were determined for anilides.