Étude critique de la mise en évidence d'un effet synergique entre pénicillines et aminoglycosides par la technique en triple couche et neutralisation enzymatique de la pénicilline

A synergistic effect was shown with gentamicin and tobramycin by means of a triple layer agar technique and enzymatic inactivation of cefamandole after only four hours' incubation. When the strain is sensitive to cefamandole and aminoglycosides, synergy is observed against all the strains studied (Staphylococcus aureus, Proteus, Klebsiella, Escherichia coli, Enterobacter, and Haemophilus influenzae). No significant difference was noted between the cefamandole-tobramycin and the cefamandole-gentamicin combinations when the microbial strains were sensitive to the three antibiotics.

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In vitro comparison of synergism between cefamandole and gentamicin or tobramycin by the triple layer agar method with enzymatic inactivation

Yourassowsky

Schoutens

Linden

et al. 1979

Infection

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Étude critique de la mise en évidence d'un effet synergique entre pénicillines et aminoglycosides par la technique en triple couche et neutralisation enzymatique de la pénicilline

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In vitro comparison of synergism between cefamandole and gentamicin or tobramycin by the triple layer agar method with enzymatic inactivation

In vitro comparison of synergism between cefamandole and gentamicin or tobramycin by the triple layer agar method with enzymatic inactivation

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