Étude de l’activité prébiotique potentielle de l’acide borique

Prieur, Benoît E.

doi:10.1016/s1387-1609(01)01266-x

Cited by 36 publications

(39 citation statements)

References 19 publications

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“…This property would have presumably prevented its accumulation under prebiotic conditions, or at least decreased its presence diminishing the centrality of its initial function. A possible solution is provided by the observation of the stabilization of adenosine by borate [11] and of ribose by borate and by borate minerals ulexite, kernite and colemanite [12]. The borate complex of ribose is more stable than the complexes of related aldopentoses [11][12][13].…”

Section: Open Accessmentioning

confidence: 99%

Borate Minerals and RNA Stability

et al. 2010

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Abstract:The abiotic origin of genetic polymers faces two major problems: a prebiotically plausible polymerization mechanism and the maintenance of their polymerized state outside a cellular environment. The stabilizing action of borate on ribose having been reported, we have explored the possibility that borate minerals stabilize RNA. We observe that borate itself does not stabilize RNA. The analysis of a large panel of minerals tested in various physical-chemical conditions shows that in general no protection on RNA backbone is exerted, with the interesting exception of ludwigite (Mg 2 Fe 3 +BO 5 ). Stability is a fundamental property of nucleic polymers and borate is an abundant component of the planet, hence the prebiotic interest of this analysis.

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Section: Open Accessmentioning

confidence: 99%

Borate Minerals and RNA Stability

et al. 2010

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“…55 This kind of catalytic activity was also found for sodium and potassium ions, 29 but the systematic study of the influence of pH, temperature, and metal concentration on the polymerization of glycine revealed a negative influence of other divalent metals. 62 , which have virtually no influence.…”

Section: Prebiotic Synthesis By Homogeneous Catalysismentioning

confidence: 80%

“…55 The borate concentration in today's seawater is only 4.45 ppm, 56 but the finding of tourmaline in 3.8-billion-year-old rocks 57 and boron minerals in carbonaceous chondrites 58 speaks in favour of moderate borate concentrations in the waters of early Earth. Their abundance has to date increased following evolution of geological environments.…”

Section: Prebiotic Synthesis By Homogeneous Catalysismentioning

confidence: 99%

Catalysis in the Primordial World

Raos

Bermanec²

2017

Kem. Ind.

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Catalysis provides orderly prebiotic synthesis and eventually its evolution into autocatalytic (self-reproduction) systems. Research on homogeneous catalysis is concerned mostly with random peptide synthesis and the chances to produce catalytic peptide oligomers. Synthesis of ribose via formose reaction was found to be catalysed by B(OH) 4 − , presumably released by weathering of borate minerals. Oxide and clay mineral surfaces provide catalytic sites for the synthesis of oligopeptides and oligonucleotides. Chemoautotrophic or iron-sulphur-world theory assumes that the first (pioneer) organisms developed by catalytic processes on (Fe/Ni)S particles formed near/close hydrothermal vents. The review provides an overlay of possible catalytic reactions in prebiotic environment, discussing their selectivity (regioselectivity, stereoselectivity) as well as geological availability of catalytic minerals and geochemical conditions enabling catalytic reactions on early Earth.

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“…minerals containing boron, which is able to form very stable complexes with vicinal hydroxyl groups (85)(86)(87).…”

Section: Resultsmentioning

confidence: 99%

Meteorite-catalyzed syntheses of nucleosides and of other prebiotic compounds from formamide under proton irradiation

Saladino

Carota

Botta

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

168

157

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Liquid formamide has been irradiated by high-energy proton beams in the presence of powdered meteorites, and the products of the catalyzed resulting syntheses were analyzed by mass spectrometry. Relative to the controls (no radiation, or no formamide, or no catalyst), an extremely rich, variegate, and prebiotically relevant panel of compounds was observed. The meteorites tested were representative of the four major classes: iron, stony iron, chondrites, and achondrites. The products obtained were amino acids, carboxylic acids, nucleobases, sugars, and, most notably, four nucleosides: cytidine, uridine, adenosine, and thymidine. In accordance with theoretical studies, the detection of HCN oligomers suggests the occurrence of mechanisms based on the generation of radical cyanide species (CN·) for the synthesis of nucleobases. Given that many of the compounds obtained are key components of extant organisms, these observations contribute to outline plausible exogenous high-energy-based prebiotic scenarios and their possible boundary conditions, as discussed.origin of life | formamide | prebiotic syntheses | nucleosides | meteorites H ypothesizing formamide (FA) as parent molecule, we explored its potentiality in synthetic processes when exposed to proton irradiation. The purpose of this analysis is to verify a possible prebiotic scenario consisting of FA, considered here as starting one-carbon atom material, of proton beams mimicking solar energetic particles as energy source, and of meteorites as catalysts. The rationale of this approach is that the results could help in outlining exogenous prebiotic models and their boundaries.FA (NH 2 CHO) is becoming one of the most intensively studied precursors for prebiotic syntheses of compounds potentially relevant for the origin of life (1-4). FA is a ubiquitous molecule in the universe. It has been detected in galactic centers (Sgr A and Sgr B), in star-forming regions of dense molecular clouds, in high-mass young stellar objects, in the interstellar medium and in comets and satellites (5)(6)(7)(8)(9)(10)(11)(12)(13)(14).With the appropriate mineral as catalyst, different ensembles of intermediates of genetic and metabolic apparatuses are simultaneously synthesized from FA under thermal conditions (i.e., by heating liquid FA between 333 and 453 K at room pressure). DNA and RNA components (15-21), amino acids (22, 23), sugars (24), and carboxylic acids (25, 26) have been obtained. Minerals tune the selectivity of these transformations (1, 2), the mechanistic pathways for the synthesis of nucleobases requiring pyrimidine (27-30) or imidazole intermediates (31,32).Within the solar system, ionizing cosmic radiation is generated by the Sun [solar cosmic rays (SCRs), primarily protons accelerated by flares and coronal mass ejections to energies typically of tens to hundreds megaelectronvolts] and is also formed by particles coming from the deep universe [galactic cosmic rays (GCRs)] (33). The SCRs and GCRs differ in their components and energy spectra, but their overwhelming co...

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Étude de l’activité prébiotique potentielle de l’acide borique

Cited by 36 publications

References 19 publications

Borate Minerals and RNA Stability

Borate Minerals and RNA Stability

Catalysis in the Primordial World

Meteorite-catalyzed syntheses of nucleosides and of other prebiotic compounds from formamide under proton irradiation

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