Etude De La Descendance De Sujets Traités Par Radiothérapie Pelvienne

Turpin, Reine; Lejeune, J; Rethore, M.-O.

doi:10.1159/000150823

Cited by 7 publications

(8 citation statements)

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“…The effects of acute exposure have been studied in the children of fathers treated for non-malignant conditions by radiotherapy. [21][22][23] All of these studies show an increased sex ratio, although only one states the time between irradiation and conception.2' The doses in these studies are generally well in excess of those in the present study.…”

Section: Comparison With Other Studies Of Radiation and The Sex Ratiomentioning

confidence: 64%

The sex ratio of children in relation to paternal preconceptional radiation dose: a study in Cumbria, northern England.

Dickinson

Parker

Binks

et al. 1996

Journal of Epidemiology & Community Health

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There was an increased sex ratio of 1.396 (95% CI: 1.127, 1.729) in the 345 children whose fathers were estimated from annual dose summaries to have received more than 10 mSv of external radiation in the 90 days preceding conception, but no significant linear trend between sex ratio and 90 day paternal preconceptional dose was found. There was no significant association between sex ratio and the external dose accumulated before the 90 day period preceding conception. Conclusions -Men employed at Sellafield fathered a greater proportion ofboys than would be expected for a Cumbrian population, which may be partly explained by their younger age distribution. A greater effect was observed in the fathers with recorded doses exceeding 10 mSv in the 90 days before conception. While this may reflect a true statistical association, it is also possible that it may be a chance finding due to imprecision in the dose estimates and consequent misclassification. (J Epidemiol Community Health 1996;50:645-652) The aim ofthe study was to investigate whether the external ionising radiation received by men employed at the nuclear installation at Sellafield, West Cumbria, affected the sex ratio of the children they subsequently fathered. We considered two hypotheses -whether the sex ratio was affected by the total cumulative radiation doses received by the fathers before conception or whether it was affected by the doses received in the immediate preconceptional period, when the sperm resulting in the conception were developing or being stored. There has been speculation that the preconceptional radiation dose received by fathers employed at Sellafield might be a risk factor for leukaemia in their children.' Subsequent research does not support this hypothesis.2 However, if preconceptional irradiation at these dose levels were to cause heritable genetic damage, childhood cancer might not be the most obvious result. Spontaneous abortions, stillbirths, congenital malformations, neonatal mortality, general childhood morbidity, or an altered sex ratio might be more likely outcomes, although such radiation induced effects would be difficult to detect.3 The present investigation of the sex ratio was carried out within a broad programme of work, examining several potential heritable effects in the offspring of Sellafield employees.

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Section: Comparison With Other Studies Of Radiation and The Sex Ratiomentioning

confidence: 64%

The sex ratio of children in relation to paternal preconceptional radiation dose: a study in Cumbria, northern England.

Dickinson

Parker

Binks

et al. 1996

Journal of Epidemiology & Community Health

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confidence: 75%

“…In man, Kaplan (1957), Turpin et al (1956), Schull and Neel (1958) and Tanaka and Okura (1958) reported that when fathers were irradiated the sex-ratio (sons/sons+ daughters) in their children increased, while it decreased if mothers were irradiated, as expected from the hypothesis mentioned above. However, Macht and Lawrence (1955) and Neel and Schull (1956) found no significant difference between the sex-ratios of children from irradiated parents and those from non-irradiated ones.…”

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confidence: 75%

A SHIFT OF SEX-RATIO IN THE PROGENY FROM IRRADIATED MALES IN <i>DROSOPHILA MELANOGASTER</i>

Moriwaki

Tobari

Ohba

et al. 1967

The Japanese journal of genetics

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On the basis of the hypothesis that sex-ratio is mainly altered by radiation-induced lethals on either paternal or maternal sex-chromosomes, it has, in general, been thought that the hereditary effects of radiation on man may be assessed by investigating a shift of sex-ratio in the progeny from irradiated parents.In man, Kaplan (1957), Turpin et al. (1956), Schull and Neel (1958) and Tanaka and Okura (1958) reported that when fathers were irradiated the sex-ratio (sons/sons+ daughters) in their children increased, while it decreased if mothers were irradiated, as expected from the hypothesis mentioned above. However, Macht and Lawrence (1955) and Neel and Schull (1956) found no significant difference between the sex-ratios of children from irradiated parents and those from non-irradiated ones. Furthermore, the remarkable fact became clear that abnormal sexuality can be caused by exceptional behavior of sex-chromosomes in parental meiosis (Ford et al. 1959;Jacobs and Strong 1959). The experiment of Russell et al. (1958Russell et al. ( , 1960) with mice showed a quite different result from the expectation based on the mutation hypothesis.On the other hand, Lindsley et al. (1958) and Herskovitz and Baumiller (1959) reported that in Drosophila irradiation with high doses failed to induce any shift in the sex-ratio of the progeny, contrary to the early results obtained by others (Hanson 1928;Muller 1928;Gowen and Gay 1933;Bauer 1939;Demerec and Fano 1944;Catchside and Lea 1945).The facts indicated above suggest that the sex-ratio is affected not only by induced sex-linked lethals, but also by some other factors such as abnormal behavior of sexchromosomes due to radiation ; i. e., radiation-induced non-disjunction or elimination of the sex-chromosomes. In fact, Savhagen (1961a, b) revealed that a considerable amount of non-disjunction or elimination of sex-chromosomes could be induced by X-rays in Drosophila melanogaster, the amount depending on the stage in which the germ cells were irradiated. Thus, the assessment of hereditary effects of radiation on man based on a sex-ratio shift in the progeny from irradiated parents seems to have encountered some new difficulties, among which, first of all, must be included the effect of irradiation of different germ cell stages on the mutation rates. In addition to the idea that dominant

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“…It was, therefore, inevitable that hypotheses involving X-linked lethal mutations should be advanced when disturbances of sex ratios were found in infants born to parents previously exposed to ionizing radiation. Although these shifts in sex ratios were small and not entirely convincing, they were the only observed changes in the offspring of irradiated parents in Hiroshima and Nagasaki (Neel and Schull, 1956) and in those of parents who had received therapeutic irradiation (Turpin, Lejeune, and Rethore, 1956). Further, in both instances and in subse-190 quent data studied by Scholte and Sobels (1964) the effects appeared to be in the same direction, viz.…”

mentioning

confidence: 87%

Determinants of Sex Proportions in Man, with Consideration of the Evidence Concerning a Contribution from X-linked Mutations to Intrauterine Death

Stevenson¹,

Bobrow²

1967

Journal of Medical Genetics

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Etude De La Descendance De Sujets Traités Par Radiothérapie Pelvienne

Cited by 7 publications

References 0 publications

The sex ratio of children in relation to paternal preconceptional radiation dose: a study in Cumbria, northern England.

The sex ratio of children in relation to paternal preconceptional radiation dose: a study in Cumbria, northern England.

A SHIFT OF SEX-RATIO IN THE PROGENY FROM IRRADIATED MALES IN <i>DROSOPHILA MELANOGASTER</i>

Determinants of Sex Proportions in Man, with Consideration of the Evidence Concerning a Contribution from X-linked Mutations to Intrauterine Death

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