Étude de la sensibilisation aux 3 acariens (Dermatophagoïdes pteronyssinus, Dermatophagoïdes farinae, Blomia tropicalis) au Maghreb et en Afrique subsaharienne dans une population de patients consultant pour une rhinite et/ou un asthme

Fekih, L.; Mjid, M.; Souissi, Z.; Hmida, A. Ben; Gueddari, Y. El; Douagui, H.; Ouédraogo, M.; Aouta, M. Dan; Béji, M.

doi:10.1016/j.reval.2014.01.033

Cited by 13 publications

(8 citation statements)

References 20 publications

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“…Mites’ sensitisation is an important and powerful risk factor of asthma[ 33 ]. Sensitisation to mites is frequent in people with asthma in Yaounde and in other African countries [ 34 , 35 , 36 ]. The level of this sensitisation is comparable to that reported in most regions of the world [ 34 , 35 , 36 , 37 ] and may therefore not explain the low prevalence of asthma in most African countries.…”

Section: Discussionmentioning

confidence: 99%

“…Sensitisation to mites is frequent in people with asthma in Yaounde and in other African countries [ 34 , 35 , 36 ]. The level of this sensitisation is comparable to that reported in most regions of the world [ 34 , 35 , 36 , 37 ] and may therefore not explain the low prevalence of asthma in most African countries. The low prevalence of smoking found in our study and which has also been reported in other African countries [ 12 , 38 ], could partially explain the low prevalence of asthma in Yaounde and across Africa.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Asthma and Allergic Rhinitis among Adults in Yaounde, Cameroon

et al. 2015

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BackgroundPopulation-based estimates of asthma and allergic rhinitis in sub-Saharan African adults are lacking. We assessed the prevalence and determinants of asthma and allergic rhinitis in urban adult Cameroonians.MethodsA community-based survey was conducted from December 2013 to April 2014 among adults aged 19 years and above (N = 2,304, 57.3% women), selected through multilevel stratified random sampling across all districts of Yaounde (Capital city). Internationally validated questionnaires were used to investigate the presence of allergic diseases. Logistic regressions were employed to investigate the determinants of allergic conditions.ResultsPrevalence rates were 2.7% (95% CI: 2.1-3.4) for asthma-ever, 6.9% (5.9-7.9) for lifetime wheezing, 2.9% (92.2-3.6) for current wheezing and 11.4% (10.1-12.7) for self-reported lifetime allergic rhinitis; while 240 (10.4%) participants reported current symptoms of allergic rhinitis, and 125 (5.4%) had allergic rhino-conjunctivitis. The prevalence of current asthma medication use and self-reported asthma attack was 0.8 (0.4-1.2) and 1 (0.6-1.4) respectively. Multivariable adjusted determinants of current wheezing were signs of atopic eczema [2.91 (1.09-7.74)] and signs of allergic rhinitis [3.24 (1.83-5.71)]. Age group 31-40 years [0.27(0.09-0.78), p = 0.016] was an independent protective factor for wheezing. Determinants of current rhinitis symptoms were active smoking [2.20 (1.37-3.54), p<0.001], signs of atopic eczema [2.84 (1.48-5.46)] and current wheezing [3.02 (1.70-5.39)].ConclusionPrevalence rates for asthma and allergic rhinitis among adults in this population were at the lower tails of those reported in other regions of the world. Beside the classical interrelation between allergic diseases found in this study, active smoking was an independent determinant of allergic rhinitis symptoms. Nationwide surveys are needed to investigate regional variations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of Asthma and Allergic Rhinitis among Adults in Yaounde, Cameroon

et al. 2015

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“…Although we cannot exclude the presence of not-yet-identified minor epitopes in type 5 HDM allergens, the study performed by El Fekih et al [37] showed that the prevalence of sensitization to B. tropicalis in Algeria concerns 25% of the tested patients. This could lead to cosensitization as well as the cross-reactivity detected in our study.…”

Section: Resultsmentioning

confidence: 87%

Cross-Reactivity between Major IgE Epitopes of Family 5 Allergens from Dermatophagoides pteronyssinus and Blomia tropicalis

Lahiani¹,

Dumez²,

Khemili³

et al. 2018

Int Arch Allergy Immunol

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Background: The aim of this work was to understand the molecular features that trigger the cross-reactivity observed between Der p 5 from Dermatophagoides pteronyssinus, Blo t 5 from Blomia tropicalis, and Der f 5 from D. farinae. Methods: We collected serum from 60 house dust mite (HDM)-allergic patients residing in the Dellys area of Boumerdès province in northern Algeria. The presence of specific IgE to Der p 5, Der f 5, and Blo t 5 was analyzed. We performed in silico analysis of the structure of the different allergens in order to identify epitopes that can elicit the cross-reactivity of the sera. Synthetic peptides corresponding to the linear epitope sequence of Der p 5, Der f 5, and Blo t 5 were used to evaluate its implication in the cross-reactivity between the allergens. We also modified the sequence of the conformational epitope of Der p 5 by site-directed mutagenesis to mimic Blo t 5. Results: Several sera of patients allergic to HDM contained specific IgE antibodies to Der p 5 and Blo t 5. We demonstrated that the linear epitope of Der p 5 and Blo t 5 is not involved in the cross-reactivity of the sera. Furthermore, mutations introduced in the sequence of Der p 5 to mimic Blo t 5 could not modulate the cross-reactivity between them. Conclusions: The major linear IgE epitopes of Der p 5 and Blo t 5 are involved in species-specific recognition. Our results may be useful for the development of a hypoallergenic vaccine against HDM group 5 allergens.

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“…De même parmi les allergènes, les acariens sont connus d'être un facteur de risque de déve-loppement d'asthme et de la rhinite [14]. Les acariens sont les allergènes les plus retrouvés au Maroc, dans différentes villes [2,15] et également à Casablanca [16]. Le constat est le même dans notre étude.…”

Section: Discussionunclassified

“…La prévalence est en augmentation dans le monde autant dans les pays industrialisés que dans les pays en voie de développement [1][2][3]. Au Maroc, la prévalence de l'asthme varie entre 6,4 et 16,2 % selon l'étude ISAAC (International Study of Asthma and Allergies in Childhood) [4].…”

Section: Introductionunclassified