Étude du polymorphisme intronique de l’enzyme de conversion de l’angiotensine I chez des coronariens tunisiens

Chalghoum, Abdelkader; Noichri, Y.; Chkioua, Latifa; Gammoudi, I.; Dandana, A.; Chahed, H.; Khelil, S.; Jeridi, Gouider; Baudin, Bruno; Ferchichi, Salima; Miled, Abdelhédi

doi:10.1016/j.ancard.2010.12.019

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…La rupture et l'érosion de la plaque athéromateuse coronaire constituent l'étiologie majeure et commune des SCA [5,6]. Les facteurs de risque coronariens sont multiples et sont classés en facteurs modifiables (hypertension artérielle [HTA], diabète, obésité, tabac, sédentarité.…”

Section: Article Originalunclassified

Metabolic interactions between the hyperhomocysteinemia and angiotensin-1 converting enzyme activity in Tunisian patients with coronary heart disease

Chalghoum

Noichri²,

Chkioua³

et al. 2012

Annales De Biologie Clinique

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Article reçu le 8 février 2012, accepté le 16 mai 2012 Résumé. L'hyperhomocystéinémie et l'hyperactivité de l'enzyme de conversion de l'angiotensine 1 (ECA1) constituent deux facteurs de risque coronariens non classiques. L'étude de la variation de ces deux paramètres chez les coronariens ainsi que l'exploration de la relation métabolique entre ces deux biomarqueurs présentent un intérêt fondamental. Dans ce cadre, 110 patients coronariens tunisiens et 80 sujets sains ont été recrutés. L'homocystéinémie était déterminée par la méthode immunologique et l'activité de l'ECA1 était mesurée par une méthode cinétique. L'étude statistique a montré une élévation statistiquement significative de ces deux marqueurs chez les patients comparés aux témoins (homocystéine : 23 ± 18 mol/L vs 9 ± 4 mol/L ; p < 0,0001), (ECA1 : 81 ± 18 UI/L vs 55 ± 18 UI/L, p < 0,0001). D'autre part, l'homocystéine et l'ECA1 varient différemment en fonction des autres facteurs de risque. Une corrélation négative statistiquement significative (r = -0,36 ; p < 0,001) est notée entre les deux paramètres ce qui reflète des interactions métaboliques et physiopathologiques complexes. Mots clés : syndrome coronarien aigu, athérosclérose, facteurs de risque, hyperhomocystéinémie, enzyme de conversion de l'angiotensine 1Abstract. Hyperhomocysteinemia and hyperactivity of the angiotensin-1 converting enzyme (ACE1) are considered two unconventional coronary risk factors. The study of the variation of these two biochemical parameters in coronary patients and metabolic investigation of the relationship between these two markers has a fundamental interest. In this context, 110 patients and 80 control subjects are recruited for our study. Homocystenemia was determined by fluorescence polarization immunoassay (FPIA). ACE1 activity was measured by kinetic method. An increased of homocysteinemia and ACE1 activity was observed in patients compared with control subjects (Hcy: 23±18 mol/L vs 9±4 mol /L; p<0.0001); (ACEI: 81±18 UI/L vs 55±18 UI/L; p<0.0001). These two markers varied differently according to the risk factors. Homocysteinemia, was negatively correlated with ACE1 activity (r = -0.36; p<0.001). The negative correlation between these two markers reflects metabolic and physiopathological interactions.

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Section: Article Originalunclassified

Metabolic interactions between the hyperhomocysteinemia and angiotensin-1 converting enzyme activity in Tunisian patients with coronary heart disease

Chalghoum

Noichri²,

Chkioua³

et al. 2012

Annales De Biologie Clinique

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“…The increasing level of ACE increases conversion of angiotensin I to angiotensin II and activates signaling pathway from inflammation, oxidative stress, and increased vascular and cardiovascular tone. Aldosterone is one of the other proteins that regulated the rigidity of vascular tone by increasing the accumulation of fibrotic tissue and is responsible in endothelial dysfunction [4], [5], [6], [7], [8].…”

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confidence: 99%

The Effect of Angiotensin-Converting Enzyme Gene Polymorphisms in the Coronary Slow Flow Phenomenon at South Sumatra, Indonesia Population

Ghanie

Partan

Indrajaya

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: The coronary slow flow phenomenon (CSFP) is believed to be affected by endothelial dysfunction ruled by renin, angiotensin, aldosterone, and the angiotensin-converting enzyme (ACE). The gene of ACE has been characterized in humans by a major insertion (I)/deletion (D) polymorphism. Serum ACE levels were associated with I/D polymorphism in the ACE-encoding gene. AIM: This study explored and analyzed the role of ACE gene polymorphism risk factors with the incidence of CSFP in the population of South Sumatra, Indonesia. METHODS: This study was a cross-sectional analytic observational study. A total of 112 CSFP and non- CSFP patients participated in this study. Blood was obtained from the study subjects then processed. Angiotensin I and aldosterone levels were examined using the enzyme-linked immunosorbent assay. The Judkins method was used in the assessment of coronary angiography, which was carried out through the femoral artery. For the examination of ACE I/D polymorphisms, genome deoxyribonucleic acid was extracted from blood cells (leukocytes), using the Wizard’s purification system and examined using the polymerase chain reaction method. All data were evaluated through the Chi-square test, two samples t-test, and Mann–Whitney U-test. All tests used two-sided significance and p < 0.05 was considered statistically significant. RESULTS: ACE I/D gene polymorphism possessed a significant effect in increasing the risk of CSFP. Genotype II polymorphism increased the risk of CSFP as much as 6.9 times compared to individuals with ID/DD genotype. The existence of allele I increased the risk of CSFP 5.7 times compared to allele D. Levels of angiotensin I and aldosterone were increased significantly in patients with CSFP. CONCLUSION: ACE I/D gene polymorphism possessed a significant effect in increasing the risk of CSFP. Genotype of II was the risk factor for the development of CSFP in population of South Sumatra, Indonesia.

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Le peptide natriurétique de type B (BNP) et l’enzyme de conversion de l’angiotensine 1 (ECA1) chez les coronariens tunisiens

Chalghoum

Noichri

Dandana

et al. 2012

Immuno-analyse & Biologie Spécialisée

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Étude du polymorphisme intronique de l’enzyme de conversion de l’angiotensine I chez des coronariens tunisiens

Cited by 6 publications

References 25 publications

Metabolic interactions between the hyperhomocysteinemia and angiotensin-1 converting enzyme activity in Tunisian patients with coronary heart disease

Metabolic interactions between the hyperhomocysteinemia and angiotensin-1 converting enzyme activity in Tunisian patients with coronary heart disease

The Effect of Angiotensin-Converting Enzyme Gene Polymorphisms in the Coronary Slow Flow Phenomenon at South Sumatra, Indonesia Population

Le peptide natriurétique de type B (BNP) et l’enzyme de conversion de l’angiotensine 1 (ECA1) chez les coronariens tunisiens

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