Étude histologique et immunohistochimique des anomalies vasculaires et inflammatoires de la rosacée

Perrigouard, C.; Peltre, Bernard; Cribier, B.

doi:10.1016/j.annder.2012.10.592

Cited by 15 publications

(12 citation statements)

References 23 publications

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“…Similar findings were reported in another study by Perrigouard et al (26) who detected no mites on the skin of patients with lupus erythematosus. In another series, Moravvej et al (27) reported Demodex spp.…”

Section: Discussionsupporting

confidence: 80%

Demodex Mite, Rosacea and Skin Melanoma; Coincidence or Association?

Talghini

Fouladi²,

Babaeinejad³

et al. 2015

TurkiyeParazitolDerg

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Objective: To examine the possible associations between Demodex folliculorum and a number of skin diseases. Methods: Standardized skin surface biopsy samples were obtained from the cheeks of 144 patients with histopathologically proven basal cell carcinoma (BCC, n=27), squamous cell carcinoma (SCC, n=28), melanoma (n=23), discoid lupus erythematosus (DLE, n=32), and rosacea (n=34). Thirty-four sex-and age-matched healthy volunteers served as controls. Mite density (per cm 2 ) and infestation (density≥5) were compared between the controls and patients. Results: Mite infestation rates (%) did not differ significantly between the controls (20.6) and patients with BCC (22.2, p=0.88), SCC (17.9, p=0.79), melanoma (4.3, p=0.08), and DLE (21.9, p=0.90). Compared with the controls, the mite infestation rate was significantly higher in patients with rosacea (47.1, p=0.02, odds ratio: 3.43, 95% confidence interval: 1.18-9.99). The mean mite density did not differ significantly between the controls (4.11±2.17) and patients with BCC (5.34±2.35, p=0.75), SCC (3.57±2.01, p=0.38), and DLE (3.56±1.34, p=0.83), whereas it was significantly higher in patients with rosacea (8.78±3.58, p=0.02) and lower in patients with melanoma (1.89±0.69, p=0.02). Conclusions: D. folliculorum may be associated with rosacea and melanoma but not with BCC, SCC, or DLE. Metot: Standardize yüzeyel deri biyopsisi örnekleri; bazal hücreli karsinom (BCC, n=27), skuamöz hücreli karsinom (SCC, n=28), melanom (n=23), diskoid lupus eritematozus (DLE, n=32), ve rozasea (n=34) tanıları histopatolojik olarak kanıtlanmış 144 hastanın yanaklarından alındı. Cinsiyet ve yaşı eşleştirilmiş 34 sağlıklı gönüllü kontrol grubunu oluşturdu. Akar dansitesi (cm 2 başına) ve enfestasyon (dansite≥5) hasta ve kontrol grubu arasında karşılaştırıldı. Bulgular: Akar enfestasyon hızları (%) kontrol grubu (20,6) ile BCC (22,2, p=0,88), SCC (17,9, p=0,79), melanom (4,3, p=0,08), ve DLE (21,9, p=0,90) hastaları arasında anlamlı bir farklılık göstermedi. Kontrol grubuna kıyasla, akar enfestasyon hızı, rozasea olanlarda anlamlı olarak yüksekti (47,1, p=0,02; odds oranı: 3,43, %95 güven aralığı: 1,18-9,99). Ortalama akar dansitesi kontrol grubu (4,11±2,17) ile BCC (5,34±2,35, p=0,75), SCC (3,57±2,01, p=0,38), ve DLE (3,56±1,34, p=0,83) hasta grupları arasında anlamlı bir fark göstermezken, kontrol grubuna kıyasla

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Section: Discussionsupporting

confidence: 80%

Demodex Mite, Rosacea and Skin Melanoma; Coincidence or Association?

Talghini

Fouladi²,

Babaeinejad³

et al. 2015

TurkiyeParazitolDerg

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“…However, multiple observations suggest that the Demodex mite may itself contribute to the early inflammatory process. Indeed, in histological studies, Demodex mites are found in 63% of cases with ETR, 85% to almost 100% of cases of PPR, and in 100% of hypertrophic forms of rosacea [ 31 , 94 ]; they have also been identified in intradermal granulomas in 3–66% of patients with granulomatous rosacea [ 25 , 128 – 131 ]. The mean facial density of the mite in patients with ETR is between the low density found in subjects with healthy skin and the very high density in those with demodicosis and PPR [ 95 , 97 , 132 – 135 ].…”

Section: Demodex Proliferation In Rosacea: a Continuum Procementioning

confidence: 99%

“…As PPR is more often observed after ETR than the inverse among patients with both PPR and ETR [ 136 ], and as the Demodex mite may be responsible for the papules and pustules of rosacea, this suggests that ETR is a condition that promotes mite proliferation [ 97 ], via a mechanism that is still unclear. One hypothesis is that vasodilation increases skin temperature [ 27 , 31 , 94 ], potentially promoting parasite reproduction, but the temperature, although it may be increased during flushes [ 137 ], does not appear to be higher in the skin of patients with ETR than in those without [ 138 ].…”

Section: Demodex Proliferation In Rosacea: a Continuum Procementioning

confidence: 99%

“…The apparent effect of ETR on Demodex proliferation [ 27 , 31 , 94 , 97 ] may be explained by the immunosuppressive properties of VEGF, which were recently described in tumor pathology. VEGF inhibits maturation of dendritic cells, induces accumulation of immunosuppressive cells, such as regulatory T cells, and inhibits the migration of T lymphocytes to the tumor, thus favoring tumor cell escape from immune system surveillance [ 139 , 140 ].…”

Section: Demodex and Immunotolerance: A Role For Vegf And Thmentioning

confidence: 99%

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The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

Forton¹

2020

Dermatol Ther (Heidelb)

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Rosacea is an inflammatory continuum, with all characteristics being already present from the onset of the disease, even if not clinically visible. Demodex proliferation also appears to be a continuum process in rosacea, and high Demodex density is beginning to be accepted as an important trigger of the inflammatory cascade and as a marker of rosacea: moreover, papulopustules of rosacea can be treated using acaricides. Immunological studies are providing new hypotheses according to which Demodex may induce tolerogenic dendritic cells and collaborate with VEGF to induce T cell exhaustion favoring its own proliferation. This proliferation may not be clinically visible initially. The interactions among VEGF, Demodex, and immunity need to be explored, and the nosology of rosacea definitions adapted accordingly. The effectiveness of treating any patient who only has visible vascular symptoms with an acaricidal cream needs to be confirmed in prospective controlled clinical trials with long-term follow-up, but it is already important to detect patients with pityriasis folliculorum among those with only vascular symptoms of rosacea in order to treat at least these patients with an acaricidal cream. DIGITAL FEATURES This article is published with digital features to facilitate understanding of the article. You can access the digital features on the article's associated Figshare page. To view digital features for this article go to

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“…Несмотря на то, что эти патологии могут иметь различную этиологию и патогенез, для них характерны некоторые общие патоморфологические признаки -изменения структуры эпидермиса и дермы, наличие маркеров клеточного воспаления. Существует большое количество исследований, посвященных изучению патоморфологических признаков распространенных акнеформных дерматозов: акне, розацеа, себорейного и периорального дерматитов [4,5,7,11,[15][16][17][18][19][20][21][22].…”

Section: Introductionunclassified

Morphofunctional changes in human skin with acneiform dermatoses

Pustovaya

Piavchenko

Alexeeva

et al. 2023

Žurnal anatomii i gistopatologii

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The aim of this study was to study the morphofunctional changes in human skin with acneiform dermatoses.Material and methods. We studied the material obtained from 6 volunteers of both sexes aged 26 to 64 years. All subjects had signs of acneiform dermatoses. Pathologically changed areas were studied in comparison with normal skin in the same patient. The subjects were anesthetized and a piece of skin 3×3 mm2 in size was taken with the punch biopsy. After standard histological sample preparation, sections were stained with hematoxylin and eosin. The counting and morphometry of skin cell structures was carried out, the presence of lymphocytes, neutrophils, eosinophils, erythrocytes, vacuolized keratinocytes and their remnants in 6 fields of view in 3 histological slides from each patient was determined from each patient under an Axioskop 2 microscope with a ToupCam TP108500A camera and ToupView software (ToupTek , China). The criterion for the degree of destructive changes in the collagen fibers of the dermis was the determination of their thickness.Results. The morphological structure of the skin in acneiform dermatosis is characterized by a significant increase in the thickness of the spinous (93,7 [82,30; 96,35] microns), granular (28,4 [22,48; 34,44] microns) and corneum (37,8 [25,32; 46,24] microns) layers of the epidermis compared to the norm (66,1 [58,30; 69,42] microns; 6,2 [5,96; 6,63] microns; 10,6 [9,81; 11,26] microns, respectively). Near the sebaceous-follicular complex, inflammatory lymphohistiocytic infiltrates were found in the dermis, represented by lymphocytes (9,5±2,2 units p.f.v.), neutrophils (2,2±0,8 units p.f.v.), eosinophils (17,2±4,0 units p.f.v.), erythrocytes outside the vessels (6,8±1,1 units p.f.v.), vacuolated keratinocytes (22,1±5,7 units p.f.v.) and keratinocyte remnants (15,1±2,4 units p.f.v.) . The number of cells in the infiltrate significantly differed from the norm. On histological preparations of patients with acneiform dermatosis, thinning of the collagen fibers of the dermis (6,0 [4,79; 8,13] microns) was observed compared to unaffected skin (10,4 [10,01; 10,67] microns).Conclusions. Morphological changes in the skin with acneiform dermatosis are manifested by hypertrophic processes of the epidermis, thinning of the collagen fibers of the papillary dermis, the presence of leukocyte infiltrate and a violation of the integrity of the basement membrane of the sebaceous glands. These changes can lead to disruption of the integrity and functioning of the histo-hematic barrier of the skin and an increase in the area of spread of the inflammatory process.

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Étude histologique et immunohistochimique des anomalies vasculaires et inflammatoires de la rosacée

Cited by 15 publications

References 23 publications

Demodex Mite, Rosacea and Skin Melanoma; Coincidence or Association?

Demodex Mite, Rosacea and Skin Melanoma; Coincidence or Association?

The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

Morphofunctional changes in human skin with acneiform dermatoses

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