Etude neurohistologique d’un cas de dystrophie grillagée de la cornée

Comparative Histopathological and Clinical Findings in Eyes with Lattice Corneal Dystrophy of two Different Types

“…The first is that lattice dystrophy constitutes a primary degenera tion of stromal collagen fibres [Fuchs, 1925: Dark and Thomson, I960]. The second theory is that corneal nerves are primarily affected, with degeneration of the collagen fibres as the consequence of nutritional disturbance due to pathologic innervation [Pillat, 1922[Pillat, , 1923Vrabec, 1957;Wolter and Henderson, 1962], Klaus et at. [1959] have reported lattice dystrophy with the bulbar paralytic form of amyotrophic lateral sclerosis and cutis hyperelastica in three sisters; one of these cases was presented by Vrabec [1957], It has been proved by Seitelberger and Nemetz [1961], and by de Souza Queiroz and Brick [1961 ], that the lattice lines are of amyloid origin.…”

Ultrastructural Changes in Lattice Dystrophy of the Cornea

“…It was suggested that it could be a primary disease of the nerves, producing a secondary degeneration of the collagen due to a trophic disturbance following the pathologic innervation. For some authors the lesions were in fact degen erated corneal nerves [Pillat, 1922: Kraupa, 1923Lowenstein, 1929: Vrabec, 1957: Wolter and Henderson, 1962, 1963, According to Kraupa [1923] the disease is a familial degeneration of the corneal nerves. Vrabec [1957] considered it as a primary dystrophy of the Schwannsheath.…”

“…For some authors the lesions were in fact degen erated corneal nerves [Pillat, 1922: Kraupa, 1923Lowenstein, 1929: Vrabec, 1957: Wolter and Henderson, 1962, 1963, According to Kraupa [1923] the disease is a familial degeneration of the corneal nerves. Vrabec [1957] considered it as a primary dystrophy of the Schwannsheath. Not all corneal nerves being affected, the corneal sensitivity should be variably decreased, but not abolished.…”

“…Another theory emphasizes that the lesions represent a primary degenera tion of the corneal stromal collagen [Paderstein, 1909;Fuchs, 1925 [Dimmer, 1899;Haab, 1899: Kipp, 1906, 1908Streiff, 1946. 1957: Van Canneyt, 1947G oar.…”

Histopathogenic Study of the Lattice Dystrophy of the Cornea

“…Pillat [1922], Vrabec [1957], and Wolter and Henderson [1962] accepted hypo thetically the nervous origin of the lattice dystrophy of the cornea. But Dark and T homp son [1960], McT igue and F ine [1964], K lintworth [1967a, b] and Hogan and Alvarado [1967] found no lesions of the nerve fibres.…”