Étude scintigraphique du drainage lymphatique de la chambre antérieure de l’œil de la souris et ses implications physiopathologiques

Guignier, B.; Bourahla, K.; Bekaert, Virgile; Brasse, David; Gaucher, David; Speeg-Schatz, C.; Bourcier, Tristan

doi:10.1016/j.jfo.2012.11.021

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…When following the diffusion of intracamerally injected tracers, the existence of drainage connections involving lymphatic vessels between the eye anterior chamber and the cervical lymph nodes has been proposed 13,14,16 . This has allowed to postulate for a contribution of lymphatics, at least in part, in the drainage of aqueous humor by the non-conventional route 5 .…”

Section: Discussionmentioning

confidence: 99%

“…from Pr McMenamin's group reported the accumulation of fluorescent antigens into cervical lymph nodes after prior intracamerular delivery into the eye anterior chamber 12 . More recent studies from Dr Guignier's team 13 and from Pr Yücel's group [14][15][16][17] have brought additional evidences for an aqueous humor outflow by an uveoscleral lymphatic pathway component. These authors showed that intracamerally injected tracers could diffuse and accumulate into mandibular and/or cervical lymph nodes, supporting a putative lymphatic aqueous humor drainage route.…”

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confidence: 98%

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Eye lymphatic defects induced by bone morphogenetic protein 9 deficiency have no functional consequences on intraocular pressure

Subileau

Acar

Carret

et al. 2020

Sci Rep

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Aqueous humor drainage is essential for the regulation of intraocular pressure (IOP), a major risk factor for glaucoma. The Schlemm’s canal and the non-conventional uveoscleral pathway are known to drain aqueous humor from the eye anterior chamber. It has recently been reported that lymphatic vessels are involved in this process, and that the Schlemm’s canal responds to some lymphatic regulators. We have previously shown a critical role for bone morphogenetic protein 9 (BMP9) in lymphatic vessel maturation and valve formation, with repercussions in drainage efficiency. Here, we imaged eye lymphatic vessels and analyzed the consequences of Bmp9 (Gdf2) gene invalidation. A network of lymphatic vessel hyaluronan receptor 1 (LYVE-1)-positive lymphatic vessels was observed in the corneolimbus and the conjunctiva. In contrast, LYVE-1-positive cells present in the ciliary bodies were belonging to the macrophage lineage. Although enlarged conjunctival lymphatic trunks and a reduced valve number were observed in Bmp9-KO mice, there were no morphological differences in the Schlemm’s canal compared to wild type animals. Moreover, there were no functional consequences on IOP in both basal control conditions and after laser-induced ocular hypertonia. Thus, the BMP9-activated signaling pathway does not constitute a wise target for new glaucoma therapeutic strategies.

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