Étude statistique des altérations dégénératives cérébrales apparaissant au cours du vieillissement; pp. 41–53

Neuropathological Studies in Epilepsy and the Presenile Dementias

“…The qualitative histological changes found in the brain both in Alzheimer's disease and the similar type of senile dementia have also been described as concomitants of 'normal' ageing (Simchowicz 1911, Gellerstedt 1933, Wildi et al 1964, Tomlinson et al 1968, Dayan 1970a. It may be possible to distinguish demented patients from 'normal' controls by quantitating the numbers of plaques and tangles (Corsellis 1962, Tomlinson et al 1970, Dayan 1970b.…”

“…It may be possible to distinguish demented patients from 'normal' controls by quantitating the numbers of plaques and tangles (Corsellis 1962, Tomlinson et al 1970, Dayan 1970b. The exact relationship between age and the incidence of plaques and tangles in the brains of 'normal' and 'demented' people (Corsellis 1962, Wildi et al 1964, Matsuyama et al 1966) are complex and, in particular, that between neurofibrillary tangles and ageing seems too variable for straightforward analysis (Fig 1; data from Dayan, 1971, in preparation). However, the age incidence of plaques seems quite similar in these three independent series and approximates to a shallow S-shaped curve.…”

“…Corsellis 0, F and A are Corsellis (1962) 'organic', 'functional' and 'all cases' groups, respectively. Data recalculatedfrom Corsellis (1962), Wildi et al (1964) and Matsuyama et al (1966) a pressing need in this disease for Golgi-impregnation studies of cortical neurones, which have been so successful, for example, in analysing neurological lesions in experimental hypothyroidism (Eayrs 1966), for estimation of neuronal populations in selected areas, and perhaps for the use of biochemical parameters of synaptic development such as those developed by Balazs et al (1968). That neuronal damage not usually accompanied by plaque or tangle formation can be important in the pathogenesis of the clinical features of Alzheimer's disease is shown by the emaciated state of some patients despite a normal diet.…”