“…Extensive vacuolation of hepatocytes has also been noted consistently in many other AMP and glycolipid disorders, including mucopolysaccharidosis types I-III [3,20,33,34], fucosidosis [7,21], G Mlgangliosidosis [28,29], and MLS I [6,22]. Only in mucopolysaccharidosis type IV [30] and in Goldberg's MLS I variant [8] is vacuolation confined to Kupffer cells without hepatocellular alteration.…”