EU proposal would ban 10,000 PFAS

Erickson, Britt E.

doi:10.47287/cen-10106-polcon1

Cited by 2 publications

(1 citation statement)

References 90 publications

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“…32 Similar regulations are being implemented in Europe as well where they plan to ban 10,000 PFAS from use, production, and sale. 33 Overall, research has demonstrated PFAS are global contaminants that have harmful environmental and biological effects. Even though regulations have been made for some PFAS, research shows there is still an accumulation of those that are banned and newer PFAS meant to replace those restricted from use.…”

Section: Environmental Risks and Regulationsmentioning

confidence: 99%

The Metabolism of 6:2 FTOH and its Role in Covalent Protein Modifications

Minocha-Mckenney

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Fluorotelomer alcohols (FTOHs) belong to a group of chemicals called per-and polyfluoroalkyl substances (PFAS). PFAS have been shown to cause toxicity in humans through exposure to household products, ingestion of dust, water, or inhalation of indoor air. Some studies have postulated the mechanism of action for FTOH metabolism, which is that certain metabolites can cause toxicity, such as hormonal discrepancies, immunotoxicity, and possible tumor aggregation. Two understudied groups of bioactive metabolites of FTOHs are the fluorotelomer saturated and unsaturated aldehydes (FTAL and FTUAL). As shown in Figure 1, these are reactive metabolites, due to their highly electrophilic α,β-unsaturated or saturated aldehyde moieties that will react with biological nucleophiles to potentially cause protein modification or inactivation. Yet, the proteins they covalently bind to are unknown. Determining specific proteins will demonstrate how biological mechanisms are affected in the presence of these metabolites. Some issues could include disruption of cellular events or cell signalling leading to toxicity. Therefore, this project focused on the specific proteins modified upon FTOH biotransformation. Our hypothesis was that 6:2 FTAL and/or 6:2 FTUAL would react immediately with the enzyme(s) that produce it, given their high reactivity. Enzymes of interest were cytochrome P450 (CYP) 2A6 and 2E1, which were determined as possible targets from previous studies as they were shown to be active for the metabolism of FTOHs. We also used CYP 3A4 as a negative control.

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Section: Environmental Risks and Regulationsmentioning

confidence: 99%

The Metabolism of 6:2 FTOH and its Role in Covalent Protein Modifications

Minocha-Mckenney

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Preliminary Screening of Per- and Polyfluoroalkyl Substances (PFAS) in Philippine Fast Food Packaging Using Liquid Chromatography–Mass Spectrometry (LC-MS)

Encarnacion,

Alcantara,

Armario

et al. 2024

Curr Res Nutr Food Sci

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Per- and polyfluoroalkyl substances (PFAS) on paper packaging resist water and oil to effectively contain food and beverages. However, previous studies have established correlations between PFAS and several diseases including COVID-19, cancers, and obesity. The goal of this collaborative research between the Philippines and Singapore is to set a baseline for PFAS levels in local packaging with the intended outcome of further increasing awareness on these contaminants in Southeast Asia, providing a starting point for migration experiments and risk assessments on PFAS in commercially-available food contact materials and articles, and initiating policy developments on these substances in the Philippines. In this study, 15 different types of PFAS were analyzed in selected paper packaging used by major quick service restaurants (QSRs) in Metro Manila. Using liquid chromatography-mass spectrometry (LC-MS), PFAS was detected in 100% of the samples with a total PFAS concentration range of 8.20-97.7 ng PFAS/100 cm2. The highest amount of PFAS compound measured across all samples was PF-3,7-DMOA (89.8 ng/100 cm2). PFAS compounds regulated in European packaging such as PFHpA, PFOA, PFNA and PFDA were also detected in all samples but at trace levels. Paper wrappers for rice and small burgers were found to have the highest total PFAS of 97.7 ng PFAS/100 cm2. This value translates to approximately 65.1 ng F/100 cm2 which is way below 10,000 ng F/100 cm2, the currently existing limit for PFAS in packaging set by the Danish Ministry of Environment and Food. While each packaging may be deemed safe compared to regulation, the compounded effects brought by use of multiple packaging, and high frequency and long-term exposures require further investigation.

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EU proposal would ban 10,000 PFAS

Abstract: March 2023 2.4.3.3. -addition of explanations for proposed and potential derogations and updated calculated numbers 2.4.4. -update of table comparing RO1 and RO2 based on revision of chapter 2.4.3.

Cited by 2 publications

References 90 publications

The Metabolism of 6:2 FTOH and its Role in Covalent Protein Modifications

The Metabolism of 6:2 FTOH and its Role in Covalent Protein Modifications

Preliminary Screening of Per- and Polyfluoroalkyl Substances (PFAS) in Philippine Fast Food Packaging Using Liquid Chromatography–Mass Spectrometry (LC-MS)

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