The main purpose of this study was to investigate the effect of the five personality factors such as religiosity, well-being and the central mechanism of self-evaluations on the overall performance in death anxiety. At the same time, other individual variables were also taken into account and formulated in order to investigate this specific issue. The relationship between the effect of personality factors to death anxiety was examined. As personality is a complex and multidimensional object, for this reason researchers attempt to create a systematic taxonomy in order to analyse it. The result of this research emerged both from the literature review that follows and from the survey that was conducted on a sample of 235 people (before adulthood students and teachers), between 17-63 years old of the region of Thessaly. The method of probability sampling and a specifically simple random sampling was used. The questionnaire was used for the needs of this quantitative research. Descriptive statistics was used in order to present the demographic data of the research and also to give the trend that arose from the answers to the research questions. Additionally, the methods of inductive statistics were focused on the question in order to rely on the findings of a sample observations. With the help of inductive statistics examination the confidence of the finding was proved. In the descriptive statistic the main characteristics of the individual variables were described. In the presented survey mainly the descriptive statistic was used in order to present the data of research participants. These results were presented schematically. Consequently, no significant differences were found between people's well-being and gender. According to research men were slightly happier than women, however, this was a negligible difference. Despite the above finding, this study significantly contributed to the promotion of the research in the specific field.