Eugenol a valuable compound for in vitro experimental research and worthwhile for further in vivo investigation

Abstract

Eugenol and isoeugenol are responsible for several pharmacological activities exhibited by nutmeg preparations. We studied their antimicrobial and antiaggregation activity in &fro and their influence on platelet tunction ex vivo. At the same time biogenetically or metabolically related derivatives were tested. Eugenol and isoeugenol (1 mg/mL) showed pronounced antibacterial properties: growth inhibition of 6 out of 10 Gram + and Gram -microorganisms was comparable with neomycin (500 pg/mL). Growth inhibition was even more pronounced for Candida species in comparison with nystatin (SOOOU/mL). Eugenol and some of its analogues inhibited growth of Aspergillus and Trichophyfon species at concentrations of 100&mL. However, cytotoxicity of the compounds will h i t their systemical use. The ICso of eugenol (3.0 X hi) on platelet aggregation. Their free hydroxy group was necessary for pharmacological activity . Ex vivo results revealed a dose-dependent blocking effect on the thromboxane biosynthesis by rat blood platelets: 66% inhibition by SOmg/kg to 96% inhibition by 400mgIkg. Eugenol and acetyleugenol given orally to rabbits had mean biological half-lives of 95 and 60 min respectively. Eugenol might be an interesting basic structure for drug design.Keywords: eugenol; platelets; chemotherapy.M) and isoeugenol (7.2 X lop7 M), were comparable with indomethacin (2.2 X

Eugenol and linalool: Comparison of their antibacterial and antifungal activities

“…Eugenol belongs to a class of phenylpropenes. Free hydroxyl groups confer the antimicrobial activity of this class (Laekeman et al, 1990). The antimicrobial activity of eugenol can be attributed to the presence of a double bond in α, β positions of the side chain and to a methyl group located in the γ position (Jung and Fahey, 1983).…”

Versatile and Synergistic Potential of Eugenol: A Review

“…Wie et al (1997) reported that eugenol reversed neuronal excitotoxic or oxidative injury and had protective effect against N-methyl-D-aspartate-induced neurotoxicity. [22][23][24][25][26][27][28][29]. Eugenol induced cell lysis of Gram-negative and Gram-positive bacteria by damaging the cell wall and membrane caused leakage of protein and lipid contents (Figure 4) [29].…”

Medicinal plants in the treatment ofHelicobacter pyloriinfections

“…Among the 30 tested Chinese herbal medicines which are used traditionally for treating gastritis-like disorders, the ethanol extracts of E. caryophyllus were strongly inhibitory to all the six H. pylori strains (Li et al, 2005). Eugenol, the main component of E. caryophillis oil, is a phenolic compound and is proven to be active against many pathogenic bacteria (Laekeman et al, 2006;Xu et al, 2013), fungi (Laekeman et al, 2006), and viruses (Tragoolpua & Jatisatienr, 2007). In one study, eugenol completely inhibited all the strains (both sensitive and resistant) at a concentration of 2 mg/mL.…”