Eugenol-Based Polymeric Materials—Antibacterial Activity and Applications

Kowalewska, Anna; Majewska-Smolarek, Kamila

doi:10.3390/antibiotics12111570

Cited by 7 publications

(2 citation statements)

References 84 publications

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“…These results agree with another study showing that chitosan nano bers are biocompatible [41]. [4] . Yield point…”

Section: Discussionsupporting

confidence: 93%

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Development and Evaluation of a Novel Nanofibrous Chitosan Dressing with Eugenol and Iodoform for Treating Alveolar Osteitis

Arabi,

Kamali,

Abbaspour

et al. 2024

Preprint

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Objective: Dry socket or alveolar osteitis is the most common complication following bone exposure. Alveolus, after the dissolution of the blood clot in the tooth socket, is accompanied by severe and persistent pain, bad breath, foul taste in the mouth, or localized lymphadenitis. The treatment of dry socket is based on pain relief to facilitate its healing process. One of the commonly used treatments for dry socket is Alvogyl, which is produced by combining indigenous red fibers from South Asia with active ingredients such as eugenol and iodoform. Since access to these fibers is challenging, finding a suitable alternative for this material is essential. Chitosan is a polymeric substance with remarkable antimicrobial properties and is considered safe for human consumption. On the other hand, the production of nanofibers offers desirable characteristics such as an increased surface-to-volume ratio, which, along with other advantages of chitosan use, such as availability and antimicrobial properties, justifies the necessity of this research. Methods and Materials: Based on the properties of chitosan, iodoform, and eugenol, formulations were prepared, including a drug-free formulation, a formulation containing 0.24% iodoform, 0.02% eugenol, and a formulation containing 0.24% iodoform with 0.02% eugenol, using an electrospinning apparatus to produce nanofibers. The characteristics of the polymeric solution, such as viscosity, pH, and electrical conductivity, were examined. The diameter, morphology, and diameter distribution of the nanofibers were investigated using SEM. XRD, DSC, and FT-IR tests were conducted to assess the crystalline properties and interaction of the materials. Drug delivery features, including tensile strength, drug loading, drug release profile, as well as cellular toxicity and minimum inhibitory concentration (MIC) of the nanofiber membrane, were evaluated. Results: Nanofibers were successfully prepared using the electrospinning method, with average fiber diameters of 64 ± 335 nm, 80 ± 360 nm, 97 ± 355 nm, and 59 ± 214 nm for drug-free fibers, fibers containing 0.24% iodoform, 0.02% eugenol, and fibers containing 0.24% iodoform with 0.02% eugenol, respectively. The addition of iodoform and eugenol to the polymer increased the electrical conductivity of the solution and the fibers but decreased the pH and tensile strength. The desired drug loading percentage was achieved for drug-free fibers and fibers containing 0.24% iodoform, 0.02% eugenol, and fibers containing 0.24% iodoform with 0.02% eugenol. FT-IR, DSC, and XRD analyses confirmed the absence of interactions between the drug and excipients in the polymeric membrane. According to the cellular toxicity tests conducted, none of the nanofibers exhibited cytotoxicity against fibroblast cells. Conclusion: Based on the conducted investigations, it can be concluded that iodoform and eugenol can be successfully loaded into chitosan and polyethylene oxide nanofibers. The obtained fibers possess mechanical strength and controlled drug release profiles, making them suitable for dry socket dressings, which should be further evaluated in in vivo tests.

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“…These results agree with another study showing that chitosan nano bers are biocompatible [41]. [4] . Yield point…”

Section: Discussionsupporting

confidence: 93%

“…In dentistry, eugenol or clove oil nds applications in dental cements, llings, and as a topical analgesic. It is also employed in the fragrance and avor industries [4].…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of a Novel Nanofibrous Chitosan Dressing with Eugenol and Iodoform for Treating Alveolar Osteitis

Arabi,

Kamali,

Abbaspour

et al. 2024

Preprint

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Assessing the Bactericidal Effectiveness of Clove Oil Nanoemulsion‐Loaded Polycaprolactone Nanofibers for Eco‐Friendly and Endurable Food Packaging

Kenawy,

Hemdan,

Abdel‐Sattar

et al. 2024

Polymers for Advanced Techs

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This research investigates the possible use of polycaprolactone (PCL) nanofiber loaded with different concentrations of clove oil (CO) as an antimicrobial bioactive agent for utilization in food packaging. CO nanoemulsions were prepared using various concentrations of CO resulting in small, spherically‐shaped particles. The codes (CO‐1, CO‐2, and CO‐3) were given to these nanoemulsions, which had relative diameters of 69 nm, 71 nm, and 150 nm, respectively. After adding CO nanoemulsion to PCL solutions, the resulting nanofiber samples (PCL‐CO 1, PCL‐CO 2, and PCL‐CO 3), showed contact angle values (131.1°, 125.1°, and 117.4°) than the unmodified PCL nanofibers without CO (PCL ‐base; 140.5°). These obtained nanofibers exhibited smooth feature. Additionally, evaluations of thermal stability revealed that PCL loaded with CO exhibited higher thermal resistance when compared to PCL nanofibers without CO loading (PCL base). The antibacterial assessments conducted on these nanofibers revealed that their efficiency against typical food spoilage bacteria, such as Pseudomonas aeruginosa, Salmonella enterica, Listeria monocytogenes, and Bacillus subtilis, improved as the concentration of CO increased. Surprisingly, the most inhibitory impact was seen at greater CO concentrations, with bacterial counts being considerably reduced by 6.5 log10 CFU/mL. Significantly, the PCL‐CO 3 nanofiber composite showed encouraging characteristics that point to its possible use in reducing the growth of microorganisms in food packaging environments. These results highlight the potential use of PCL nanofibers loaded with CO (PCL‐CO 3 in particular) as multi‐purposes antibacterial agent appropriate for using in food packaging.

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Physicochemical properties and antimicrobial efficacy of eugenol nanoemulsion formed by spontaneous emulsification

Hassan,

Alijaniha,

Jafari

et al. 2024

Chem. Pap.

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Eugenol-Based Polymeric Materials—Antibacterial Activity and Applications

Cited by 7 publications

References 84 publications

Development and Evaluation of a Novel Nanofibrous Chitosan Dressing with Eugenol and Iodoform for Treating Alveolar Osteitis

Development and Evaluation of a Novel Nanofibrous Chitosan Dressing with Eugenol and Iodoform for Treating Alveolar Osteitis

Assessing the Bactericidal Effectiveness of Clove Oil Nanoemulsion‐Loaded Polycaprolactone Nanofibers for Eco‐Friendly and Endurable Food Packaging

Physicochemical properties and antimicrobial efficacy of eugenol nanoemulsion formed by spontaneous emulsification

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