Eukaryotic DNA methylation and demethylation – sequence and strand specificity

Weissbach, Arthur

doi:10.1002/bies.950070610

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…1987) and undermethylated in extra-embryonic tissues (van der Ploeg & Flavell 1980;Sanford et al 1985;Rossant et al 1986). In differentiated tissues, demethylation is correlated with specific gene expression (reviewed in Doerfler (1983); Weissbach ( 1987)). Therefore, in development, a methylated ground state has generally been favoured with demethylation being associated with onset of expression of specific genes in different tissues at different times.…”

Section: Dna Methylation In Developmentmentioning

confidence: 99%

Changes in DNA methylation during mouse embryonic development in relation to X-chromosome activity and imprinting

Monk

1990

Phil. Trans. R. Soc. Lond. B

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Changing DNA methylation patterns during embryonic development are discussed in relation to differential gene expression, changes in X-chromosome activity and genomic imprinting. Sperm DNA is more methylated than oocyte DNA, both overall and for specific sequences. The methylation difference between the gametes could be one of the mechanisms (along with chromatin structure) regulating initial differences in expression of parental alleles in early development. There is a loss of methylation during development from the morula to the blastocyst and a marked decrease in methylase activity. De novo methylation becomes apparent around the time of implantation and occurs to a lesser extent in extra-embryonic tissue DNA. In embryonic DNA, de novo methylation begins at the time of random X-chromosome inactivation but it continues to occur after X-chromosome inactivation and may be a mechanism that irreversibly fixes specific patterns of gene expression and X-chromosome inactivity in the female. The germ line is probably delineated before extensive de novo methylation and hence escapes this process. The marked undermethylation of the germ line DNA may be a prerequisite for X-chromosome reactivation. The process underlying reactivation and removal of parent-specific patterns of gene expression may be changes in chromatin configuration associated with meiosis and a general reprogramming of the germ line to developmental totipotency.

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Section: Dna Methylation In Developmentmentioning

confidence: 99%

Changes in DNA methylation during mouse embryonic development in relation to X-chromosome activity and imprinting

Monk

1990

Phil. Trans. R. Soc. Lond. B

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“…Furthermore, the nutritional quality and safety aspects of wild vegetables consumed in Bangladesh showed crude protein contents of 16.69% in Helencha (E. fluctuans) and 21.45% in Kalmishak (I. aquatica) [28]. Protein is a vital nutrient that plays numerous essential roles in the human body, including tissue growth and repair, enzyme and hormone production, immune function, and transport and storage in the animal body [29][30][31].…”

Section: Crude Protein Content Of Edible Aquatic Weed Paper Sheetsmentioning

confidence: 99%

A Green Approach to Valorizing Abundant Aquatic Weeds for Nutrient-Rich Edible Paper Sheets Production in Bangladesh

Suraiya,

Bristy,

Ali

et al. 2023

Clean Technol.

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The rapid and unprecedented expansion of the global population highlights concerns about the sufficiency of food resources to sustain this growth. This study investigates and substantiates the feasibility of renewable food resources in order to meet the nutritional requirements of consumers. Three edible aquatic weeds, helencha (Enhydra fluctuans), malancha (Alternanthera philoxeroides), and kalmi (Ipomoea aquatica), were used to produce edible paper sheets. The composition of the raw aquatic weeds and paper sheet samples was analyzed, including the proximate composition, amino acid content, minerals and heavy metal contents, and bioactive compounds. The dried raw aquatic weeds and paper sheets showed similar proximate compositions, with carbohydrates being the highest component (50.38–64.63%), followed by crude protein (15.25–19.13%), ash (9.30–15.88%), and lipid (1.55–3.43%). The raw weeds and paper sheets were rich in essential minerals like Na, Ca, and Zn with contents ranging from 27.7 mg/100 g to 30.4 mg/100 g, 126.8 mg/100 g to 489.65 mg/100 g, and 4.5 mg/100 g to 16.3 mg/100 g, respectively. Acceptable levels of heavy metals, including Ni, Pb, and Cu, were found. The paper sheets contained seven essential and eight non-essential amino acids. Among the essential amino acids, the phenylalanine content was the highest at 2735.9 mg/100 g in E. fluctuans paper sheets, followed by methionine at 2377.29 mg/100 g in the raw E. fluctuans and histidine at 1972.6 mg/100 g in E. fluctuans paper sheets. A. philoxeroides sheets showed the highest total amino acid content (16,146.81 mg/100 g), while I. aquatica showed the lowest (13,118.67 mg/100 g). The aquatic weed paper sheets were rich in bioactive compounds, and the numbers in E. fluctuans, A. philoxeroides, and I. aquatica paper sheets were 31, 33, and 40, respectively. There were no significant changes in the nutritional content of the aquatic weeds in paper sheet form compared with the raw weeds, which suggests promising prospects for their production and consumption as a source of nutrition and bioactive compounds.

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Green Approach to Valorize Abundant Aquatic Weeds for Nutrient-Rich Edible Paper Sheets Production in Bangladesh

Suraiya,

Bristy,

Ali

et al. 2023

Preprint

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Three edible aquatic weeds, helencha (Enhydra fluctuans), malancha (Alternanthera philoxeroides), and kalmi (Ipomoea aquatica), were used to produce edible paper sheets. The composition of the raw and paper sheet samples was analyzed, including proximate composition, amino acid content, minerals and heavy metal contents, and bioactive compounds. The dried raw and paper sheets showed similar proximate composition, with carbohydrates being the highest (50.38-64.63%), followed by crude protein (15.25-19.13%), ash (9.30-15.88%), and lipid (1.549-3.43%). The weeds and paper sheets were rich in essential minerals like Na, Ca, Zn, and Fe. Acceptable levels of heavy metals, including Ni, Pb, and Cu, were found. The paper sheets contained seven essential and eight non-essential amino acids. A. philoxeroides sheets showed the highest amino acid content (16146.81mg/100g), while I. aquatica showed the lowest (13118.67 mg/100g). The aquatic weeds paper sheets were rich in containing bioactive compounds and the number in E. fluctuans, A. philoxeroides, and I. aquatica paper sheets were 31, 33, and 40, respectively. There were no significant changes in the nutritional content of aquatic weeds in paper sheet form compared to the raw weeds which suggests promising prospects for the production and consumption as a source of nutrition and bioactive compounds.

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Eukaryotic DNA methylation and demethylation – sequence and strand specificity

Cited by 3 publications

References 19 publications

Changes in DNA methylation during mouse embryonic development in relation to X-chromosome activity and imprinting

Changes in DNA methylation during mouse embryonic development in relation to X-chromosome activity and imprinting

A Green Approach to Valorizing Abundant Aquatic Weeds for Nutrient-Rich Edible Paper Sheets Production in Bangladesh

Green Approach to Valorize Abundant Aquatic Weeds for Nutrient-Rich Edible Paper Sheets Production in Bangladesh

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