Eukaryotic Translation Initiation Factor-6 Enhances Histamine and IL-2 Production in Mast Cells

Oh, Chad K.; Filler, Scott G.

doi:10.4049/jimmunol.166.5.3606

Cited by 15 publications

(6 citation statements)

References 46 publications

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“…The specific down-regulation of eIF6 in Lck −/− cells may result from a combination of multiple signaling defects. eIF6 has been shown to be up-regulated in mast cells by FceR1 crosslinking and to be inhibited by cyclosporin A (45), and Ca 2+ signaling is particularly compromised in the absence of Lck in both CD4 (15) and CD8 T cells (47). Additionally, eIF6 promoter activity has been shown to be regulated by GABP (48), an Etslike transcription factor partially regulated by ERK (49), which is less strongly activated in Lck −/− cells.…”

Section: Discussionmentioning

confidence: 99%

Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells

Tan

Knight

Sbarrato

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Global transcriptomic and proteomic analyses of T cells have been rich sources of unbiased data for understanding T-cell activation. Lack of full concordance of these datasets has illustrated that important facets of T-cell activation are controlled at the level of translation. We undertook translatome analysis of CD8 T-cell activation, combining polysome profiling and microarray analysis. We revealed that altering T-cell receptor stimulation influenced recruitment of mRNAs to heavy polysomes and translation of subsets of genes. A major pathway that was compromised, when TCR signaling was suboptimal, was linked to ribosome biogenesis, a rate-limiting factor in both cell growth and proliferation. Defective TCR signaling affected transcription and processing of ribosomal RNA precursors, as well as the translation of specific ribosomal proteins and translation factors. Mechanistically, IL-2 production was compromised in weakly stimulated T cells, affecting the abundance of Myc protein, a known regulator of ribosome biogenesis. Consequently, weakly activated T cells showed impaired production of ribosomes and a failure to maintain proliferative capacity after stimulation. We demonstrate that primary T cells respond to various environmental cues by regulating ribosome biogenesis and mRNA translation at multiple levels to sustain proliferation and differentiation.

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Section: Discussionmentioning

confidence: 99%

Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells

Tan

Knight

Sbarrato

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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“…Cycling cells have higher eIF6 levels than post-mitotic cells [17]. Rapid induction occurs during mast cell activation [44], rupture of the epidermal barrier [77] or liver regrowth (unpublished data; Fig. 1).…”

Section: Introductionmentioning

confidence: 92%

eIF6 anti-association activity is required for ribosome biogenesis, translational control and tumor progression

Brina

Miluzio

Ricciardi

et al. 2015

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

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“…Many studies on the mast cell line HMC1 and the pluripotent hematopoietic cell line UT7D1 have demonstrated that HDC-gene expression is subject to posttranscriptional control. Therefore, the chromosomal configuration and methylation of the HDC-promoter is likely to account for its cell-specific expression [46,47]. It has also been reported that PMA stimulates a strong increase in HDC activity in UT7D1, which is affected by actinomycin D, and that is not paralleled by enhanced HDC mRNA expression.…”

Section: B Regulation Of Histaminementioning

confidence: 99%

Histamine, Histamine Receptors, and their Role in Immunomodulation: An Updated Systematic Review

Shahid¹,

Tripathi²,

Sobia³

et al. 2009

TOIJ

105

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Histamine, a biological amine, is considered as a principle mediator of many pathological processes regulating several essential events in allergies and autoimmune diseases. It stimulates different biological activities through differential expression of four types of histamine receptors (H1R, H2R, H3R and H4R) on secretion by effector cells (mast cells and basophils) through various immunological or non-immunological stimuli. Since H4R has been discovered very recently and there is paucity of comprehensive literature covering new histamine receptors, their antagonists/agonists, and role in immune regulation and immunomodulation, we tried to update the current aspects and fill the gap in existing literature. This review will highlight the biological and pharmacological characterization of histamine, histamine receptors, their antagonists/agonists, and implications in immune regulation and immunomodulation.

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Eukaryotic Translation Initiation Factor-6 Enhances Histamine and IL-2 Production in Mast Cells

Cited by 15 publications

References 46 publications

Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells

Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells

eIF6 anti-association activity is required for ribosome biogenesis, translational control and tumor progression

Histamine, Histamine Receptors, and their Role in Immunomodulation: An Updated Systematic Review

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