In this paper we introduce the concept of minimum-weight edge-discriminators in hypergraphs, and study its various properties. For a hypergraph H = (V, E ), a function λ :, for every two distinct hyperedges Ei, Ej ∈ E . An optimal edge-discriminator on H, to be denoted by λH, is an edge-discriminator on H satisfying v∈V λH(v) = min λ v∈V λ(v), where the minimum is taken over all edge-discriminators on H. We prove that any hypergraph H = (V, E ), with |E | = n, satisfies v∈V λH(v) ≤ n(n + 1)/2, and equality holds if and only if the elements of E are mutually disjoint. For r-uniform hypergraphs H = (V, E ), it follows from results on Sidon sequences that v∈V λH(v) ≤ |V| r+1 + o(|V| r+1 ), and the bound is attained up to a constant factor by the complete r-uniform hypergraph. Next, we construct optimal edge-discriminators for some special hypergraphs, which include paths, cycles, and complete r-partite hypergraphs. Finally, we show that no optimal edge-discriminator on any hypergraph H = (V, E ), with |E | = n (≥ 3), satisfies v∈V λH(v) = n(n + 1)/2 − 1. This shows that not all integer values between n and n(n + 1)/2 can be the weight of an optimal edge-discriminator of a hypergraph, which, in turn, raises many other interesting combinatorial questions.1991 Mathematics Subject Classification. 05C65, 05C78, 90C27.