Eulerian modelling of lung deposition with sectional representation of aerosol dynamics

Mitsakou, Christina; Helmis, C. G.; Housiadas, C.

doi:10.1016/j.jaerosci.2004.08.008

Cited by 81 publications

(51 citation statements)

References 38 publications

(43 reference statements)

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“…The normal contact force was computed by using the Hertz-Mindlin no-slip model [5]. The contact force can be identified by describing particle contacts as damped harmonic oscillators.…”

Section: Flow and Particle Transport Simulationmentioning

confidence: 99%

“…Various modelling approaches have been applied for analysing the aerosol deposition performance within the pulmonary system [1,2], for example semi-empirical [3], symmetric generation [4], trumpet [5], asymmetric multiple path modes [6], stochastic, asymmetric generation [2] and computational fluid dynamics (CFD) models [7]. Unfortunately, the results of these models vary primarily due to different lung inlet morphometric conditions such as breathing periods, pressure gradients and mathematical modelling techniques.…”

Section: Introductionmentioning

confidence: 99%

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Importance of Physical and Physiological Parameters in Simulated Particle Transport in the Alveolar Zone of the Human Lung

Çiloğlu

Athari²,

Bölükbaşi

et al. 2017

Applied Sciences

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Abstract:The trajectory and deposition efficiency of micron-sized (1-5 µm) particles, inhaled into the pulmonary system, are accurately determined with the aid of a newly developed model and modified simulation techniques. This alveolar model, which has a simple but physiologically appropriate geometry, and the utilized fluid structure interaction (FSI) methods permit the precise simulation of tissue wall deformation and particle fluid interactions. The relation between tissue movement and airflow in the alveolated duct is solved by a two-way fluid structure interaction simulation technique, using ANSYS Workbench (Release 16.0, ANSYS INC., Pittsburgh, PA, USA, 2015). The dynamic transport of particles and their deposition are investigated as a function of aerodynamic particle size, tissue visco-elasticity, tidal breathing period, gravity orientation and particle-fluid interactions. It is found that the fluid flows and streamlines differ between the present flexible model and rigid models, and the two-way coupling particle trajectories vary relative to one-way particle coupling. In addition, the results indicate that modelling the two-way coupling particle system is important because the two-way discrete phase method (DPM) approach despite its complexity provides more extensive particle interactions and is more reliable than transport results from the one-way DPM approach. The substantial difference between the results of the two approaches is likely due to particle-fluid interactions, which re-suspend the sediment particles in the airway stream and hence pass from the current generation.

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“…The normal contact force was computed by using the Hertz-Mindlin no-slip model [5]. The contact force can be identified by describing particle contacts as damped harmonic oscillators.…”

Section: Flow and Particle Transport Simulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Importance of Physical and Physiological Parameters in Simulated Particle Transport in the Alveolar Zone of the Human Lung

Çiloğlu

Athari²,

Bölükbaşi

et al. 2017

Applied Sciences

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“…The determination of the particle deposition at different parts of the respiratory system is an essential step in investigating possible risks from exposure to desert dust. To this end, a recently developed dosimetry model (Mitsakou et al, 2005) is applied. The model calculates deposited inhaled aerosols in the various regions of the human respiratory tract, taking into account the aerosol properties (e.g.…”

Section: Mitsakou Et Al: Saharan Dust Levels In Greece and Receivmentioning

confidence: 99%

Saharan dust levels in Greece and received inhalation doses

et al. 2008

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Abstract. The desert of Sahara is one of the major sources of mineral dust on Earth, producing around 2×108 tons/yr. Under certain weather conditions, dust particles from Saharan desert get transported over the Mediterranean Sea and most of Europe. The limiting values set by the directive EC/30/1999 of European Union can easily be exceeded by the transport of desert dust particles in the south European Region and especially in urban areas, where there is also significant contribution from anthropogenic sources. In this study, the effects of dust transport on air quality in several Greek urban areas are quantified. PM10 concentration values from stationary monitoring stations are compared to dust concentrations for the 4-year period 2003–2006. The dust concentration values in the Greek areas were estimated by the SKIRON modelling system coupled with embedded algorithms describing the dust cycle. The mean annual dust contribution to daily-averaged PM10 concentration values was found to be around or even greater than 10% in the urban areas throughout the years examined. Natural dust transport may contribute by more than 20% to the annual number of exceedances – PM10 values greater than EU limits – depending on the specific monitoring location. In a second stage of the study, the inhaled lung dose received by the residents in various Greek locations is calculated. The particle deposition efficiency of mineral dust at the different parts of the human respiratory tract is determined by applying a lung dosimetry numerical model, which incorporates inhalation dynamics and aerosol physical processes. The inhalation dose from mineral dust particles was greater in the upper respiratory system (extrathoracic region) and less significant in the lungs, especially in the sensitive alveolar region. However, in cases of dust episodes, the amounts of mineral dust deposited along the human lung are comparable to those received during exposure in heavily polluted urban or smoking areas.

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“…While Lagrangian models can well represent the inhalation and deposition from continuous nebulizers, single breath inhalers and smart nebulizers derive their enhanced performance from time dependent effects that can only be accurately captured by Eulerian models. Eulerian deposition models have been available for many years (Egan & Nixon (1985); Roth et al (2003); Taulbee & Yu (1975)) and recently have also incorporated one-way coupled hygroscopicity (Mitsakou et al (2005)). However, they have not found widespread use, probably because of the relative complexity of their implementation.…”

Section: Modelling Drug Deposition In the Lungmentioning

confidence: 99%

Improving the Likelihood of Success in Trials and the Efficiency of Delivery of Mucolytics and Antibiotics

Lange¹

2012

Cystic Fibrosis - Renewed Hopes Through Research

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Eulerian modelling of lung deposition with sectional representation of aerosol dynamics

Cited by 81 publications

References 38 publications

Importance of Physical and Physiological Parameters in Simulated Particle Transport in the Alveolar Zone of the Human Lung

Importance of Physical and Physiological Parameters in Simulated Particle Transport in the Alveolar Zone of the Human Lung

Saharan dust levels in Greece and received inhalation doses

Improving the Likelihood of Success in Trials and the Efficiency of Delivery of Mucolytics and Antibiotics

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