Eupatilin: a natural pharmacologically active flavone compound with its wide range applications

Nageen, Bushra; Sarfraz, Iqra; Rasul, Azhar; Hussain, Ghulam; Rukhsar, Fariha; Irshad, Somia; Riaz, Ammara; Selamoğlu, Zeliha; Ali, Muhammad

doi:10.1080/10286020.2018.1492565

Cited by 61 publications

(51 citation statements)

References 85 publications

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“…Although the causes of ALD are not well established, some studies have revealed that alcohol-induced oxidative stress, hepatotoxicity, and the complex interactions involving alcohol metabolism, liver cells, and multiple cytokines can affect the progression of ALD [26]. The antioxidant and anti-inflammatory effects of eupatilin were examined in several studies [15,17,27,28]. Recently, pharmacokinetic study also performed to demonstrate its potential benefit for diverse applications.…”

Section: Discussionmentioning

confidence: 99%

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The hepato-protective effect of eupatilin on an alcoholic liver disease model of rats

Lee

Nam

Choi

et al. 2020

Korean J Physiol Pharmacol

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Eupatilin is known to possess anti-apoptotic, anti-oxidative, and antiinflammatory properties. We report here that eupatilin has a protective effect on the ethanol-induced injury in rats. Sprague-Dawley rats were divided into 6 groups: control, vehicle, silymarin, eupatilin 10 mg/kg, eupatilin 30 mg/kg, and eupatilin 100 mg/kg. Plasma levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were analyzed to determine the extent of liver damage. Total cholesterol (TC) and triglycerides (TG) were analyzed to determine the level of liver steatosis. Malondialdehyde level, superoxide dismutase (SOD) activity, and glutathione (GSH) level were analyzed to determine the extent of oxidative stress. Tumor necrosis factor (TNF)- and interleukin (IL)-1 were quantified to verify the degree of inflammation. Based on our findings, chronic alcohol treatment significantly changed the serum indexes and liver indicators of the model rats, which were significantly improved by eupatilin treatment. Rats in the eupatilin-treatment group showed reduced levels of AST, ALT, TG, TC, TNF-, and IL-1, increased SOD activity and GSH levels, and improved overall physiology compared to the alcoholic liver disease model rats. H&E staining also verified the eupatilin-mediated improvement in liver injury. In conclusion, eupatilin inhibits alcohol-induced liver injury via its antioxidant and anti-inflammatory effects.

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Section: Discussionmentioning

confidence: 99%

“…5,7-Dihydroxy-3΄,4΄,6-trimethoxyflavone (eupatilin) is a pharmacologically active flavone extracted from an Artemisia species [15]. Eupatilin is known to have several pharmacological properties, such as anti-oxidative, anti-apoptosis, and anti-inflammatory [16,17].…”

Section: Original Articlementioning

confidence: 99%

The hepato-protective effect of eupatilin on an alcoholic liver disease model of rats

Lee

Nam

Choi

et al. 2020

Korean J Physiol Pharmacol

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“…Infusions of génépi group plants has long been used as thermogenic agents to fatigue, indigestion, and airway infections in people . Modern medical research has revealed the pharmacological effects of eupatilin on anti‐inflammatory, anti‐ulcer, anti‐oxidative, and antineoplastic agent . In addition, eupatilin has shown anti‐diabetic, anti‐arthritis, and anti‐proliferative activity.…”

Section: Introductionmentioning

confidence: 99%

Eupatilin regulates proliferation and cell cycle of cervical cancer by regulating hedgehog signalling pathway

Zhao

Zou

Zhang

et al. 2020

Cell Biochemistry & Function

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Eupatilin (5,7-dihydroxy-3 0 ,4 0 ,6-trimethoxyflavone) is a natural active substance found in génépi group plants, and its pharmacological activities has been proven to be useful in the treatment of various cancers. However, whether eupatilin demonstrates anti-cancer activity in cervical cancer is still under evaluation. To clarify this, cancer cell lines and nude mouse model were used in this study. The results indicated that eupatilin could inhibit the occurrence of cervical cancer both in vivo and in vitro.Cervical cancer cell lines (C4-1, HeLa, Caski, and Siha) and Ect1/E6E7 cells were incubated with eupatilin (40μM) for 48 hours. Compared with the control group, the viability of cervical cancer cells decreased significantly, while the apoptotic cells increased significantly. Cell cycle analysis showed that eupatilin treatment of HeLa and Caski cells reduced the proliferation index. Eupatilin at 40 mg/kg also inhibited tumour growth in tumour-bearing mice. Interestingly, weakened hedgehog signalling was observed in cervical cancer cells and tumours from tumour-bearing mice after eupatilin treatment. Our results reveal the inhibitory effect of eupatilin on cervical cancer and shed new light on the molecular mechanism of its therapeutic effect.

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“…Eupatilin, a bioactive flavone of Artemisia asiatica Nakai (Asteraceae), has been reported to have broad properties such as anti-cancer, antioxidant, and anti-inflammatory effects [6]. In addition, Kim et al [7] reported that eupatilin has anti-allergic reactions in activated guinea pig lung mast cells, suggesting that eupatilin may be used for the treatment of inflammatory disorders associated with allergic diseases such as asthma.…”

Section: Introductionmentioning

confidence: 99%

Eupatilin alleviates airway remodeling via regulating phenotype plasticity of airway smooth muscle cells

Ren

Wang

et al. 2020

Bioscience Reports

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Childhood asthma is a common chronic airway disease, and its severe form remains a challenge. Eupatilin is a bioactive natural flavone that has been found to possess potential anti-asthma activity. However, the roles of eupatilin in asthma remain to be elucidated. In the present study, airway smooth muscle cells (ASMCs) were applied for the in vitro investigation since their phenotype plasticity make great contribution to airway remodeling during asthma pathogenesis. Our results showed that eupatilin suppressed the transforming growth factor β1 (TGF-β1)-induced proliferation and migration of ASMCs. Exposure of ASMCs to eupatilin increased the expressions of contractile markers smooth muscle α-actin (α-SMA) and myocardin, whereas expressions of extracellular matrix (ECM) proteins type I collagen (Coll I) and fibronectin were reduced. Furthermore, eupatilin treatment reversed the activation of nuclear factor-κ B (NF-κB), signal transducer and activator of transcription 3 (STAT3) and AKT pathways caused by TGF-β1 in ASMCs. These findings suggested that eupatilin might attenuate airway remodeling via regulating phenotype plasticity of ASMCs.

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Eupatilin: a natural pharmacologically active flavone compound with its wide range applications

Cited by 61 publications

References 85 publications

The hepato-protective effect of eupatilin on an alcoholic liver disease model of rats

The hepato-protective effect of eupatilin on an alcoholic liver disease model of rats

Eupatilin regulates proliferation and cell cycle of cervical cancer by regulating hedgehog signalling pathway

Eupatilin alleviates airway remodeling via regulating phenotype plasticity of airway smooth muscle cells

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