Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic β-cell function in type 2 diabetic mice

Kang, Young-Jin; Jung, Un Ju; Lee, Mi-Kyung; Kim, Hye-Jin; Jeon, Seon-Min; Park, Yong Bok; Chung, Hae‐Gon; Baek, Nam‐In; Lee, Kyung Tae; Jeong, Tae‐Sook; Choi, Myung‐Sook

doi:10.1016/j.diabres.2008.06.012

Cited by 66 publications

(50 citation statements)

References 36 publications

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“…C NMR) and MS data with those that were reported in the literature (Kang et al, 2008). The structure of the com-pound is determined as Eupatilin as shown in the Figure 1C.…”

mentioning

confidence: 83%

Eupatilin: A flavonoid compound isolated from the artemisia plant, induces apoptosis and G2/M phase cell cycle arrest in human melanoma A375 cells

Shawi#¹

2011

Afr. J. Pharm. Pharmacol.

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Eupatilin is a flavonoid compound isolated from the Artemisia plant. Eupitillin possesses antioxidant as well as potent anticancer properties. In this study, for the first time, we examined the anti-proliferative effects of Eupatilin in human melanoma A375 cells and its ability to induce apoptosis and cell cycle arrest. Eupatilin specifically induced morphological changes in A375 cells and was less toxic to the normal mouse splenocytes. The inhibitory effects of A375 cells were associated with the DNA damage, apoptosis, and cell cycle arrest at G2/M phase in a dose-dependent manner. The apoptotic effects of Eupatilin were further verified by using Annexin V-FITC/propidium iodide staining in flow cytometry. These results suggest that Eupatilin is an effective natural compound that worth further mechanistic and therapeutic studies against human melanoma.

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“…C NMR) and MS data with those that were reported in the literature (Kang et al, 2008). The structure of the com-pound is determined as Eupatilin as shown in the Figure 1C.…”

mentioning

confidence: 83%

Eupatilin: A flavonoid compound isolated from the artemisia plant, induces apoptosis and G2/M phase cell cycle arrest in human melanoma A375 cells

Shawi#¹

2011

Afr. J. Pharm. Pharmacol.

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“…The A. princeps used in the previous studies were variants cultivated in Korea, and may have had a different composition of phytochemicals than Japanese A. princeps. Furthermore, the anti-diabetic effects of Korean A. princeps appeared to be mediated through stimulation of glucokinase activity, inhibition of glucose-6-phosphatase activity in the liver, and enhanced pancreatic insulin secretion, 8) but the regulation of glucose uptake in muscle and adipose tissues through GLUT4 translocation was not examined in these previous studies.…”

Section: Discussionmentioning

confidence: 95%

“…7,8) The active constituent is thought to be a flavone, eupatilin, which had a functional anti-diabetic effect by enhancing hepatic and plasma glucose metabolism. 8) Hence, we analyzed the amount of eupatilin in our APE by HPLC analysis, and confirmed that our APE did not contain eupatilin. The A. princeps used in the previous studies were variants cultivated in Korea, and may have had a different composition of phytochemicals than Japanese A. princeps.…”

Section: Discussionmentioning

confidence: 99%

“…A previous study reported that one of the flavones, eupatilin, is an active compound in A. princeps. 7,8) We checked the amount of eupatilin in our APE as compared with standard compounds obtained from PhytoLab (Vestenbergsgreuth, Germany), and confirmed that our APE did not contain eupatilin. We could not identify some peaks because they were absent from our polyphenolic library data, but one of the unidentified a The phenolic content of APE was determined using an HPLC system constructed for simultaneous determination of polyphenols in foods.…”

Section: Polyphenol Analysismentioning

confidence: 99%

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Artemisia princeps Extract Promoted Glucose Uptake in Cultured L6 Muscle Cells via Glucose Transporter 4 Translocation

Yamamoto¹,

Ueda

Kawabata

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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“…There are >400 classes of Artemisia identified (34). One of them, AP, has previously been demonstrated to exert various biological activities in vitro (35) and in vivo (36). ISTP, an active component of APE, suppressed LPS-induced nitric oxide production in murine macrophage RAW 264.7 cells (16).…”

Section: Discussionmentioning

confidence: 99%

Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL-33 production and STAT-1 activation in HaCaT keratinocytes

Jang

Kwon

et al. 2017

Molecular Medicine Reports

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Abstract. The present study aimed to investigate the antiinflammatory effect and mechanism of action of isosecotanapartholide (ISTP), isolated from Artemisia princeps Pampanini extract (APE). The effects of ISTP and APE on the proliferation of human keratinocytes following stimulation by tumor necrosis factor-α/interferon-γ were assessed. ISTP and APE downregulated the expression levels of signal transducer and activator of transcription-1 (STAT-1), and reduced interleukin-33 (IL-33) production. ISTP and APE inhibited the mRNA expression levels of thymus and activation-regulated chemokine (TARC/CCL17) in a dose-dependent manner. Western blot analysis demonstrated that ISTP and APE dose-dependently inhibited protein expression levels of intercellular adhesion molecule-1 and phosphorylation of STAT-1. The results of the present study indicate that ISTP may inhibit TARC/CCL17 production in human epidermal keratinocytes via the STAT-1 signaling pathway and may be associated with the inhibition of IL-33 production. The current study indicated that ISTP is an active component in APE and may be a potential therapeutic agent for the treatment of inflammatory skin disorders.

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Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic β-cell function in type 2 diabetic mice

Cited by 66 publications

References 36 publications

Eupatilin: A flavonoid compound isolated from the artemisia plant, induces apoptosis and G2/M phase cell cycle arrest in human melanoma A375 cells

Eupatilin: A flavonoid compound isolated from the artemisia plant, induces apoptosis and G2/M phase cell cycle arrest in human melanoma A375 cells

Artemisia princeps Extract Promoted Glucose Uptake in Cultured L6 Muscle Cells via Glucose Transporter 4 Translocation

Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL-33 production and STAT-1 activation in HaCaT keratinocytes

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