Euphorbia bicolor (Euphorbiaceae) latex phytochemicals and applications to analgesia

Basu, Paramita; Averitt, Dayna L.; Maier, Camelia

doi:10.1016/b978-0-12-820237-1.00035-1

Cited by 1 publication

(1 citation statement)

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“…It is a rich source of phytochemicals, which have been studied extensively throughout time. 38,39 Phytochemical analysis of various Euphorbia species indicated the presence of different phytochemicals, including sterols, diterpenes, triterpenes, carotenoids, flavonoids and alkaloids known to possess diverse biological activities. [40][41][42][43] According to previous studies, over 5% of Euphorbia species are utilized in traditional medicine (TM) worldwide to treat various digestive, respiratory, and inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Characterization and evaluation of multiple biological activities of phytosynthesized gold nanoparticles using aqueous extract ofEuphorbia dendroides

El-Moaty

Ismail

Abu-Khudir

et al. 2022

Nanomaterials and Nanotechnology

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Novel metallic nanoparticles (NPs), such as biosynthesized gold nanoparticles (AuNPs), have been extensively studied because of their wide applications. Consequently, the present investigation aimed at the biosynthesis, characterization, and comparative assessment of biological activities of AuNPs. Biosynthesized AuNPs (ED-AuNPs) were synthesized using aqueous extract of Euphorbia dendroides ( E. dendroides) aerial parts (EDAE), which functions as a reducing and stabilizing agent by its nature. Presence of tannins, saponins, flavonoids, alkaloids, glycosides/or carbohydrates, steroids, and terpenes was revealed by the qualitative phytochemical analysis of EDAE. Characterization of the biosynthesized AuNPs was attained by UV-Visible spectrophotometry, transmission electron microscopy (TEM), XRD, and Fourier transform infrared (FTIR). The cytotoxic effects of ED-AuNPs and EDAE were assessed in vitro against HepG2 and HCT-116 cancer cells. The MTT assay revealed a significant cytotoxic effect of ED-AuNPs and EDAE on HepG2 (IC50 = 41.72 ± 1.26 and 55.26 ± 2.25 μg mL−1) as well as HCT-116 (IC50 = 44.96 ± 3.23 and 69.83 ± 0.96 μg mL−1) cells, thus indicating their potential anticancer activity. Furthermore, ED-AuNPs exhibited potent anti-diabetic activity, with an IC50 value of 19.8 ± 1.97 µg mL−1, pointing to their plausible use as therapeutics in the treatment of diabetes, as well as a promising antimicrobial activity against H. pylori.

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