Euphorbia hirta leaf extracts increase urine output and electrolytes in rats

Johnson, Patricia B; Abdurahman, E. M.; Tiam, Emmanuel A; Aliyu, Ibrahim; Hussaini, Isa M.

doi:10.1016/s0378-8741(98)00143-3

Cited by 81 publications

(54 citation statements)

References 9 publications

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“…Regarding the secretion of electrolytes, the ethanol extract of E. hirta increased the excretion of HCO 3 -, decreased the loss of K + and had little effect on renal removal of Na + . Whereas, the water extract increased the urine excretion of Na + , K + and HCO 3 -that was similar to acetazolamide (Johnson et al, 1999).…”

Section: Effects Of E Hirta On Renal Systemmentioning

confidence: 75%

“…Two flavonoids have been isolated from E. hirta, namely quercitrin and myricitrin (Johnson et al, 1999;Chen, 1991). In general, flavonoids have been reported to possess several proven medicinal properties including antioxidant (Kandaswami & Middleton, 1994), anti-allergic (Singh et al, 2006), antiinflammatory component of asthma (Miller, 2001) and antidiarrheal activity (Galvez et al, 1993;Mallavadhani et al, 2002).…”

Section: Flavonoidsmentioning

confidence: 99%

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Potential Applications of Euphorbia hirta in Pharmacology

Shih¹,

Cherng²

2012

Drug Discovery Research in Pharmacognosy

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Section: Effects Of E Hirta On Renal Systemmentioning

confidence: 75%

Section: Flavonoidsmentioning

confidence: 99%

Potential Applications of Euphorbia hirta in Pharmacology

Shih¹,

Cherng²

2012

Drug Discovery Research in Pharmacognosy

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“…The water extract increased the urine excretion of Na + , K + and HCO3 -. while, the ethanol extract increased the excretion of HCO3 -, decreased the loss of K + and had little effect on renal removal of Na + [108].…”

Section: Diuretic Effectmentioning

confidence: 85%

Pharmacology and therapeutic potential of Euphorbia hirta (Syn: Euphorbia pilulifera)- A review

Al-Snafi¹

2017

IOSRPHR

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Abstract:-The phytochemical screening of Euphorbia hirta revealed that the plant contained reducing sugars, terpenoids, alkaloids, steroids, tannins, proteins, fats, oils, gums, mucilages, glycoside, saponin, coumarin, cardiac glycosides, anthroquinones, flavanoids and phenolic compounds. The previous pharmacological studies showed that Euphorbia hirta exerted antioxidant, antimicrobial, sedative anxiolytic, antiepileptic, antiinflammatory, analgesic, antipyretic, antihistaminic, antiasthmatic, antidiabetic, anticancer, wound healing, gastrointestinal, diuretic, antiparasitic, immunological, hepatoprotective, galactogenic, angiotensin converting enzyme inhibiting and anti-dipsogenic activities. The current review discussed the chemical constituents, pharmacological and therapeutic potential of Euphorbia hirta.

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“…The FF acted in an opposite manner to furosemide. While furosemide inhibits electrolyte (Na + and K + ) reabsorption in the thick, ascending limb of the loop of Henle (Johnson et al, 1999), FF seemed to have activated electrolyte reabsorption. The rich flavonoid content of FF suggests that flavonoids found in A. vogelii are responsible for its antidiuretic activity.…”

Section: Discussionmentioning

confidence: 96%

Diuretic, Antidiuretic and Laxative Activities of Anthocleista Vogelii Extracts in Rats

Anyanwu¹,

Onyeneke²,

Ofoha³

et al. 2017

AJTCAM

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Background: Anthocleista vogelii Planch is a medicinal plant used by traditional healers in the treatment of Malaria, hypertension, ulcer, obesity, diabetes, and as a diuretic and purgative in Africa. Therefore, the present study sought to evaluate the diuretic, antidiuretic and laxative activities of the root bark of A. vogelii extracts and fractions in male SpragueDawley rats. Materials and methods: Sixty rats were placed in 10 groups which included: control (normal saline), furosemide/sodium picosulfate (25 mg/kg) as standard drugs, methanol extracts (250 mg/kg and 500 mg/kg), and 125 mg/kg and 250 mg/kg of saponin, flavonoid and neutral alkaloid fractions of A. vogelii. The drugs/extracts/fractions were administered orally using normal saline as the vehicle. Results: The 500 mg/kg methanol extracts (ME) significantly increased (p<0.05) the urine volume and electrolytes (Na + , K + and Cl -) excreted, while 125 mg/kg and 250 mg/kg flavonoid fraction (FF) decreased significantly (p<0.05) urine volume and electrolytes (Na + , K + and Cl -) excreted, but doses of saponin fraction (SF) and neutral alkaloid fraction (NAF) had no significant difference (p<0.05) compared to the control after 5 hrs. ME, SF, NAF significantly increased (p<0.05) the fecal output of the animals when compared to the control, while FF showed no significant difference (p<0.05) after 8 hrs of administration. Conclusions: This study determined that ME revealed diuretic activity, although not remarkable to furosemide, while FF showed antidiuretic activity, and potent laxative activities were discovered in ME and SF of A. vogelii.

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Euphorbia hirta leaf extracts increase urine output and electrolytes in rats

Cited by 81 publications

References 9 publications

Potential Applications of Euphorbia hirta in Pharmacology

Potential Applications of Euphorbia hirta in Pharmacology

Pharmacology and therapeutic potential of Euphorbia hirta (Syn: Euphorbia pilulifera)- A review

Diuretic, Antidiuretic and Laxative Activities of Anthocleista Vogelii Extracts in Rats

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