EuReCa ONE⿿27 Nations, ONE Europe, ONE Registry

Gräsner, Jan–Thorsten; Lefering, Rolf; Koster, Rudolph W.; Masterson, Siobhán; Böttiger, Bernd W.; Herlitz, Johan; Wnent, Jan; Tjelmeland, Ingvild; Rosell-Ortiz, Fernando; Mäurer, H.; Baubin, Michael; Mols, Pierre; HadžibegoviL·, Irzal; Ioannides, Marios; Škulec, Roman; Wissenberg, Mads; Salo, Ari; Hubert, Hervé; Νικολάου, Νικόλαος; Lóczi, Gerda; Svavarsdóttir, Hildigunnur; Semeraro, Federico; Wright, P.J.; Clarens, Carlo; Pijls, Ruud; Cebula, Grzegorz; Correia, Vitor Gouveia; Cimpoeşu, Diana; Raffay, Violetta; Trenkler, Stefan; Markota, Andrej; Strömsöe, Anneli; Burkart, Roman; Perkins, Gavin D.; Bossaert, Leo; Kaufmann, Marc; Thaler, Markus; Maier, Martin; Prause, Gerhard; Trimmel, Helmut; Longueville, Diane de; Préseau, Thierry; Biarent, Dominique; Mélot, Christian; Mpotos, Nicolas; Monsieurs, Koenraad G.; Voorde, Patrick Van de; Vanhove, Marie; Lievens, Pascale; Faniel, Mathias; Keleuva, Slobodanka; Lazarević, Milan; Ujević, Radmila Majhen; Devcic, Mato; Bardak, Branka; Barisic, Fabijan; Antičević, Silvija Hunyadi; Georgiou, Marios; Truhlás, Anatolij; Knor, Jisí; Smržová, Eva; Sviták, Roman; Šín, Robin; Mokrejš, Petr; Lippert, Freddy; Hallikainen, Juhana; Hoikka, Marko; Iirola, Timo; Jama, Timo; Jäntti, Helena; Jokisalo, Raimo; Jousi, Milla; Kirves, Hetti; Kuisma, Markku; Laine, Jukka; Länkimäki, Sami; Loikas, Petri; Lund, Vesa; Määttä, Teuvo; Nal, Heini; Niemelä, H; Portaankorva, Petra; Pylkkänen, Marko; Sainio, Marko; Setälä, Piritta; Tervo, Jerry; Väyrynen, Taneli; Murgue, Davy; Champenois, A.; Fournier, Marc; Meyrán, Daniel; Tabary, Romain; Avondo, Aurélie; Gelin, Gelin; Simonnet, Bruno; Joly, M.; Megy-Michoux, Isabelle; Paringaux, Xavier; Duffait, Yves; Vial, Michael; Segard, Julien; Narcisse, Sophie; Hamban, David; Hennache, Jonathan; Thiriez, Sylvain; Doukhan, Mathieu; Vanderstraeten, Carine; Morel, Jean-Charles; Majour, Gilles; Michenet, Corinne; Tritsch, Laurent; Dubesset, Marc; Peguet, Olivier; Piñero, David P.; Guillaumée, F; Fuster, Patrick; Ciacala, Jean-François; Jardel, Benoît; Letarnec, Jean-Yves; Goes, Frank; Gosset, Pierre; Vergne, Muriel; Bär, Christian; Branche, Fabienne; Prineau, Stevens; Lagadec, Steven; Cornaglia, Carole; Ursat, Cécile; Bertrand, Philìppe; Agostinucci, Jean Marc; Nadiras, P.; Linares, Géraldine Gonzales de; Jacob, Line; Revaux, François; Pernot, Thomas; Roudiak, Nathalie; Ricard-Hibon, A.; Villain-Coquet, Laurent; Beckers, Stefan; Hanff, Thomas C.; Strickmann, Bernd; Wiegand, Nicolai; Wilke, Petra; Sues, Harald; Bogatzki, Stefan; Baumeier, Wolfgang; Pohl, Kai; Werner, Bert; Fischer, Hans; Zeng, Torsten; Popp, Erik; Günther, Andreas; Hochberg, Andreas; Lechleuthner, A.; Schewe, Jens-Christian; Lemke, Hans; Wranze-Bielefeld, Erich; Böhn, Andreas; Roeßler, Markus; Naujoks, Frank; Sensen, Frank; Esser, Torben; Fischer, Matthias; Meßelken, M.; Rose, Christopher C.; Schlüter, Gabriele; Lotz, W.; Corzilius, Michael; Muth, Claus-Martin; Diepenseifen, C. J.; Tauchmann, Björn; Birkholz, Torsten; Flemming, Andreas; Herrmann, Stefanie; Kreimeier, U.; Kill, Clemens; Marx, F. J.; Schröder, R; Lenz, W.; Botini, Glykeria; Grigorios, Barakos; Giannakoudakis, N.; Zervopoulos, Michail; Papangelis, Dimitrios; Petropoulou-Papanastasiou, Sofia; Liaskos, Themistoklis; Papanikolaou, Spyridon; Karabinis, Andréas; Zentay, Attila; ÿorsteinsson, Hólmgeir; Gilsdóttir, Anna; Birgisson, Svavar A.; Guðmundsson, Fjölnir Freyr; Hreiðarsson, Hallgrímur; ÿrnason, Björgvin; Hermannsson, Hermann; Björnsson, Gísli; Friðriksson, Brynjar ÿór; Baldursson, Gunnar; Höskuldsson, ÿrmann; Valgarðsdottir, Jórunn; ÿsmundardóttir, Matthildur; Guðmundsson, Guðmundur A.; Kristjánsson, Hjörtur; ÿórarinsson, Eyþór Rúnar; Gudlaugsson, Jon Oskar; Skarphéðinsson, Sigurður; Peratoner, Alberto; Santarelli, Andrea; Sabetta, Cesare; Gordini, Giovanni; Sesana, Giovanni; Giudici, Riccardo; Savastano, Simone; Pellis, Tommaso; Beissel, Jean; Uhrig, Jean; Manderscheid, Tom; Klop, Marco; Stammet, Pascal; Koch, Marc; Welter, Philippe; Schuman, Robert; Bruins, Wendy; Amin, Hesam; Braa, Nina; Bratland, Staale; Buanes, Eirik Alnes; Drægni, Tomas; Johnsen, Knut Roar; Mathisen, Wenche Torunn; Oedegaarden, Terje; Oppedal, Marie; Reksten, Alf Stolt-Nielsen; Roedsand, Mats Eirik; Steen-Hansen, Jon Erik; Dyrda, Marta; Frejlich, Anna; MaciL·g, Ssawomir; Osadnik, Sonia; Weryk, Ireneusz; Mendonça, Eugénio; Freitas, C.; Cruz, P Carolina; Caldeira, Carmo; Barros, José; Vale, Luís; Brazão, António; Jardim, Nuno; Rocha, Fernanda Mota; Duarte, Ricardo Codas; Fernandes, Nicodemos; Ramos, Pedro; Jardim, Margarida; Reis, Miguel; Ribeiro, Rômulo José da Costa; Zenha, Sérgio; Fernandes, Jorge; Francisco, Juan; Assis, David N.; Abreu, Fernanda Ferreira de; Freitas, Dinarte; Ribeiro, Leonardo; Azevedo, Paulo; Calafatinho, Débora; Jardim, Rui; Pestana, Aleixo; Faria, R; Opriţă, B; Grasu, Alis; Nedelea, Paul; Sovar, Sorina; Agapi, Florin; KliL·koviL·, Aleksandar; LaziL·, Aleksandra; NikoliL·, Bogdan; Zivanovic, Bogdan; MartinoviL·, Branislav; MilenkoviL·, Dušan; Damir, HuseinoviL·; Koprivica, Jovanka; JakšiL·, Kornelija Horvat; Pajor, Margit; MiliL·, Saša; VidoviL·, Mirko; Glamoclija, Radojka Petrovic; Andjelic, Sladjana; Vlajovic, Sladjana; BabiL·, Zlatko; Fiser, Z; Androvič, Peter; Bajerovská, Ľubica; Chabroň, Miroslav; Dobias, Viliam; Havlíková, Eva; Horáňová, Božena; Kratochvílová, Renáta; Kubova, Dana; Murgaš, Ján; Patráš, Juraj; Šimák, Ladislav; Snarskij, Vladimir; Zaviaticova, Zuzana; Zuffova, Marcela; Roig, Francesc Escalada; Santos, Luis Sánchez; Echarri-Sucunza, Alfredo; Torres, Juan Antonio Cordero; Muñoz, Guadalupe Inza; Valle, Marta Martínez del; Rozalen, I. Ceniceros; Sánchez, Enrique Martín; Berlanga, María Victoria Raúl Canabal; Olalde, Karlos Ibarguren; Azpiazu, José Ignacio Ruiz; García-Ochoa, María José; López-Navarro, Rafael Zoyo; Quesada, José Manuel Adsuar; Ramas, José Antonio Cortés; Vergel, Francisco J. Mellado; Messa, J. B. López; Valle, Patricia Fernández del; Anselmi, Luciano; Benvenuti, Breganzona Claudio; Batey, Nigel; Ambulance, Yorkshire; Booth, Scott; Bucher, Patricia; Deakin, Charles D.; Duckett, Jay; Ji, Chen; Loughlin, Nancy; Lumley-Holmes, Jenny; Lynde, Jessica; Mersom, Frank; Ramsey, Carly; Robinson, Clare; Spaight, Robert; Dosanjh, Sukhdeep; Virdi, G; Whittington, Andrew

doi:10.1016/j.resuscitation.2016.06.004

Cited by 583 publications

(134 citation statements)

References 29 publications

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“…We observed bystander CPR in excess of 40% among all rhythm arrests and approaching 60% in the Utstein subgroup, results that surpass other North American and Asian reports and that compare favorably to European experiences 23, 24, 25. We also observed modest temporal improvements in bystander CPR; however, the increase in bystander CPR was more modest than other programmatic initiatives that have corresponded to outcome improvements 26, 27, 28.…”

Section: Discussionsupporting

confidence: 43%

Multistate 5‐Year Initiative to Improve Care for Out‐of‐Hospital Cardiac Arrest: Primary Results From the HeartRescue Project

Diepen

Girotra

Abella

et al. 2017

JAHA

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BackgroundThe HeartRescue Project is a multistate public health initiative focused on establishing statewide out‐of‐hospital cardiac arrest (OHCA) systems of care to improve case capture and OHCA care in the community, by emergency medical services (EMS), and at hospital level.Methods and ResultsFrom 2011 to 2015 in the 5 original HeartRescue states, all adults with EMS–treated OHCA due to a presumed cardiac cause were included. In an adult population of 32.8 million, a total of 64 988 OHCAs—including 10 046 patients with a bystander‐witnessed OHCA with a shockable rhythm—were treated by 330 EMS agencies. From 2011 to 2015, the case‐capture rate for all‐rhythm OHCA increased from an estimated 39.0% (n=6762) to 89.2% (n=16 103; P<0.001 for trend). Overall survival to hospital discharge was 11.4% for all rhythms and 34.0% in the subgroup with bystander‐witnessed OHCA with a shockable rhythm. We observed modest temporal increases in bystander cardiopulmonary resuscitation (41.8–43.5%, P<0.001 for trend) and bystander automated external defibrillator application (3.2–5.6%, P<0.001 for trend) in the all‐rhythm group, although there were no temporal changes in survival. There were marked all‐rhythm survival differences across the 5 states (8.0–16.1%, P<0.001) and across participating EMS agencies (2.7–26.5%, P<0.001).ConclusionsIn the initial 5 years, the HeartRescue Project developed a population‐based OHCA registry and improved statewide case‐capture rates and some processes of care, although there were no early temporal changes in survival. The observed survival variation across states and EMS systems presents a future challenge to elucidate the characteristics of high‐performing systems with the goal of improving OHCA care and survival.

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Section: Discussionsupporting

confidence: 43%

Multistate 5‐Year Initiative to Improve Care for Out‐of‐Hospital Cardiac Arrest: Primary Results From the HeartRescue Project

Diepen

Girotra

Abella

et al. 2017

JAHA

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“…The incidence of out-of-hospital CA is approximately 80 patients per 100,000 persons annually [1]. Despite advances in resuscitation, outcomes remain dismal, with 10% of patients surviving until hospital discharge and 5% experiencing full neurologic recovery [1]. …”

Section: Introductionmentioning

confidence: 99%

Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest: a “two-hit” model

2017

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Hypoxic ischemic brain injury (HIBI) after cardiac arrest (CA) is a leading cause of mortality and long-term neurologic disability in survivors. The pathophysiology of HIBI encompasses a heterogeneous cascade that culminates in secondary brain injury and neuronal cell death. This begins with primary injury to the brain caused by the immediate cessation of cerebral blood flow following CA. Thereafter, the secondary injury of HIBI takes place in the hours and days following the initial CA and reperfusion. Among factors that may be implicated in this secondary injury include reperfusion injury, microcirculatory dysfunction, impaired cerebral autoregulation, hypoxemia, hyperoxia, hyperthermia, fluctuations in arterial carbon dioxide, and concomitant anemia.Clarifying the underlying pathophysiology of HIBI is imperative and has been the focus of considerable research to identify therapeutic targets. Most notably, targeted temperature management has been studied rigorously in preventing secondary injury after HIBI and is associated with improved outcome compared with hyperthermia. Recent advances point to important roles of anemia, carbon dioxide perturbations, hypoxemia, hyperoxia, and cerebral edema as contributing to secondary injury after HIBI and adverse outcomes. Furthermore, breakthroughs in the individualization of perfusion targets for patients with HIBI using cerebral autoregulation monitoring represent an attractive area of future work with therapeutic implications.We provide an in-depth review of the pathophysiology of HIBI to critically evaluate current approaches for the early treatment of HIBI secondary to CA. Potential therapeutic targets and future research directions are summarized.

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“…OHCA is common, yet survival outcomes are poor, with substantial regional and international variation. [1][2][3][4][5] Survival from OHCA ranges from 8-16.1%. [6] Measures to maximise favourable neurological outcomes are a research priority for both patients and clinicians.…”

Section: Accepted Manuscript Introductionmentioning

confidence: 99%

Does care at a cardiac arrest centre improve outcome after out-of-hospital cardiac arrest? — A systematic review

et al. 2019

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Please cite this article as: Yeung J, Matsuyama T, Bray J, Reynolds J, Skrifvars MB, Does care at a cardiac arrest centre improve outcome after out-of-hospital cardiac arrest? -A systematic review, Resuscitation (2019), https://doi.on behalf of the Education, Implementation and Team Task Force and Advanced Life Support Task Force of the International Liaison Committee on Resuscitation AIMTo perform a systematic review to answer 'In adults with attempted resuscitation after non-traumatic cardiac arrest does care at a specialised cardiac arrest centre (CAC) compared to care in a healthcare facility not designated as a specialised cardiac arrest centre improve patient outcomes?' METHODSThe PRISMA guidelines were followed. We searched bibliographic databases (Embase, MEDLINE and the Cochrane Library (CENTRAL)) from inception to 1 st August 2018. Randomised controlled trials (RCTs) and non-randomised studies were eligible for inclusion. Two reviewers independently scrutinized studies for relevance, extracted data and assessed quality of studies. Risk of bias of studies and quality of evidence were assessed using ROBINS-I tool and GRADEpro respectively. Primary outcomes were survival to 30 days with favourable neurological outcomes and survival to hospital discharge with favourable neurological outcomes. Secondary outcomes were survival to 30 days, survival to hospital discharge and return of spontaneous circulation (ROSC) post-hospital arrival for patients with ongoing resuscitation. This systematic review was registered in PROSPERO (CRD 42018093369) RESULTSWe included data from 17 observational studies on out-of-hospital cardiac arrest (OHCA) patients in meta-analyses. Overall, the certainty of evidence was very low. Pooling data from only adjusted analyses, care at CAC was not associated with increased likelihood of survival to 30 days with favourable neurological outcome (OR 2.92, 95%CI 0.68 to 12.48) and survival to 30 days (OR 2.14, 95%CI 0.73 to 6.29) compared to care at other hospitals. Whereas patients cared for at CACs had improved survival to hospital discharge with favourable neurological outcomes (OR 2.22, 95%CI 1.74 to 2.84) and survival to hospital discharge (OR 1.85, 95%CI 1.46 to 2.34). CONCLUSIONSVery low certainty of evidence suggests that post-cardiac arrest care at CACs is associated with improved outcomes at hospital discharge. There remains a need for high quality data to fully elucidate the impact of CACs.

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EuReCa ONE⿿27 Nations, ONE Europe, ONE Registry

Cited by 583 publications

References 29 publications

Multistate 5‐Year Initiative to Improve Care for Out‐of‐Hospital Cardiac Arrest: Primary Results From the HeartRescue Project

Multistate 5‐Year Initiative to Improve Care for Out‐of‐Hospital Cardiac Arrest: Primary Results From the HeartRescue Project

Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest: a “two-hit” model

Does care at a cardiac arrest centre improve outcome after out-of-hospital cardiac arrest? — A systematic review

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