European Association of Urology Guidelines on Male Infertility: The 2012 Update

Jungwirth, A.; Giwercman, Aleksander; Tournaye, Herman; Diemer, Thorsten; Kopa, Zsolt; Dohle, Gert R.; Krausz, Csilla

doi:10.1016/j.eururo.2012.04.048

Cited by 909 publications

(759 citation statements)

References 58 publications

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“…This reinforces current guideline recommendations on gonadotropin treatment of these men, because it induces the appearance of spermatozoa in the ejaculate in the large majority of treated subjects. (Jungwirth et al, 2012). From available studies, a mean sperm concentration of 5.92 million per mL was obtained after gonadotropin supplementation.…”

Section: Discussionmentioning

confidence: 99%

Factors affecting spermatogenesis upon gonadotropin‐replacement therapy: a meta‐analytic study

et al. 2014

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SUMMARYA meta-analysis was performed to systematically analyse the results of gonadotropin and GnRH therapy in inducing spermatogenesis in subjects with hypogonadotropic hypogonadism (HHG) and azoospermia. An extensive Medline and Embase search was performed including the following words: 'gonadotropins' or 'GnRH', 'infertility', 'hypogonadotropic', 'hypogonadism' and limited to studies in male humans. Overall, 44 and 16 studies were retrieved for gonadotropin and GnRH therapy, respectively. Of those, 43 and 16 considered the appearance of at least one spermatozoa in semen, whereas 26 and 10 considered sperm concentration upon gonadotropin and GnRH, respectively. The combination of the study results showed an overall success rate of 75% (69-81) and 75% (60-85) in achieving spermatogenesis, with a mean sperm concentration obtained of 5.92 (4.72-7.13) and 4.27 (1.80-6.74) million/ mL for gonadotropin and GnRH therapy, respectively. The results upon gonadotropin were significantly worse in studies involving only subjects with a pre-pubertal onset HHG, as compared with studies involving a mixed population of pre-and post-pubertal onset [68% (58-77) vs. 84% (76-89), p = 0.011 and 3.37 (2.25-4.49) vs. 12.94 (8.00-17.88) million/mL, p < 0.0001; for dichotomous and continuous data, respectively]. A similar effect was observed also upon GnRH. No difference in terms of successful achievement of spermatogenesis and sperm concentration was found for different FSH preparations. Previous use of testosterone replacement therapy (TRT) did not affect the results obtained with gonadotropins. Finally, a higher success rate was found for subjects with lower levels of gonadotropins at the baseline and for those using both human chorionic gonadotropin and FSH. Gonadotropin therapy, even with urinary derivatives, is a suitable option in inducing/restoring fertility in azoospermic HHG subjects. Gonadotropins appear to be more efficacious in subjects with a pure secondary nature (low gonadotropins) and a post-pubertal onset of the disorder, whereas previous TRT does not affect outcome.

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Section: Discussionmentioning

confidence: 99%

Factors affecting spermatogenesis upon gonadotropin‐replacement therapy: a meta‐analytic study

et al. 2014

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“…Semen analysis is the main predictor of male's infertility. Most infertility cases of male's idiopathic infertility are diagnosed to be oligoasthenoteratozoospermia (1). Therefore, improving semen parameters among males 4 Iran Red Crescent Med J.…”

Section: Discussionmentioning

confidence: 99%

“…About 15% of couples are infertile (1). Infertility is an important problem, which is also important for psychosocial issues.…”

Section: Introductionmentioning

confidence: 99%

Improvement of Semen Parameters in a Man With Idiopathic Severe Oligoasthenoteratozoospermia Using Date Palm Pollen (Phoenix dactylifera L.) Based on Iranian Traditional Medicine: A Case Report and Literature Preview

Karimi

Asbagh

Rahimi

et al. 2018

Iran Red Crescent Med J

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Introduction: Almost 50% of infertilities are associated with males and among them 30to 50% are idiopathic. Empirical treatments are used in idiopathic male infertility, yet not enough scientific evidence is available for the application of such remedies. date palm pollen (DPP) is one of the drugs suggested for such patients in Iranian traditional medicine (ITM). Case Presentation: This study was performed on a 35-year-old male patient with idiopathic infertility. He previously had severe oligoasthenoteratozoospermia and was under medical supervision at Yas hospital of the Tehran University of Medical Sciences from August 2016 to February 2017, where he was treated with DPP at a dose of 3 g twice daily, for three months. The second semen analysis was carried out after a quarter of the treatment period, followed by re-analyses after one and three months of finalizing the treatment period. The results obtained showed impressive improvement in the quality of semen parameters. Within six months, the initial values of normal morphology (1%), total motility (3%), progressive motility (0.0), and sperm concentration (0.1 million) increased to 20%, 60%, 10%, and 10 million, respectively. Conclusions:The results of this study indicate that the drug may be operative in improving semen parameters in such patients, and more clinical studies are required in this regard.

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“…16 The frequency and type of Y chromosome microdeletions varied according to ethnic, regional differences, selection criteria for patient samples or methodological differences. 17 In this study, 20.4% of the studied Egyptian NOA infertile men had Yq deletions; on the other side, Medica et al 18 found no Y chromosome microdeletions in NOA men in Croatia (Europe), India, Taiwan (Asia) and Morocco (Africa).…”

Section: Discussionmentioning

confidence: 99%

Molecular Characterization of Some Genetic Factors Controlling Spermatogenesis in Egyptian Patients with Male Infertility

Fayez¹,

El-Sayed²,

El-Desouky³

et al. 2012

International Journal of Infertility &Amp; Fetal Medicine

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Men with severe infertility suffer a high risk of Y chromosome deletion, hence screening for these cases is recommended prior to treatment with assisted reproduction. Our study aimed to investigate and detect the azoospermia factor (AZF) region deletion, rearrangement and deleted azoospermia (DAZ) gene copy number variations in Egyptian azoospermic infertile men. This was tested on 54 Egyptian nonobstructive azoospermic (NOA) infertile men, with age ranged from 21 to 45 years (mean: 31.4 ± 6.1 years), by STS ± multiplex PCR using a set of 14 sequence tagged sites (STSs) from three different regions of the Y chromosome: AZFa, AZFb, AZFc and sY587/DraI PCR-RFLP assay to determine DAZ copy number variations. The results revealed a significant prevalence of AZFc subtypes deletion and reduced DAZ gene dosage in Egyptian azoospermic cases affecting Y chromosome deletions. To our knowledge, this study is the first one to investigate AZFc subtypes deletion and DAZ gene dosage in Egyptian infertile men. We concluded that DAZ genes deletion is a risk factor for spermatogenic damage.

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European Association of Urology Guidelines on Male Infertility: The 2012 Update

Cited by 909 publications

References 58 publications

Factors affecting spermatogenesis upon gonadotropin‐replacement therapy: a meta‐analytic study

Factors affecting spermatogenesis upon gonadotropin‐replacement therapy: a meta‐analytic study

Improvement of Semen Parameters in a Man With Idiopathic Severe Oligoasthenoteratozoospermia Using Date Palm Pollen (Phoenix dactylifera L.) Based on Iranian Traditional Medicine: A Case Report and Literature Preview

Molecular Characterization of Some Genetic Factors Controlling Spermatogenesis in Egyptian Patients with Male Infertility

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