European consensus statement on leptospirosis in dogs and cats

Schuller, S.; Francey, Thierry; Hartmann, Katrin; Hugonnard, Marine; Kohn, Barbara; Nally, Jarlath E.; Sykes, Jane E.

doi:10.1111/jsap.12328

Cited by 241 publications

(467 citation statements)

References 141 publications

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“…[66][67][68][69] Experimental studies suggest that cats are largely resistant to acute leptospirosis although reports of clinical cases suggests that this is a possibility. 67,70 A study by Rodriguez and colleagues has compared seropositivity and urinary PCR between CKD cats and non-age matched controls. 68 Seropositivity was significantly different between the two groups (7.2% non-CKD, 14.9% CKD cats) although PCR results were not.…”

Section: Association Of the Development Of Chronic Kidney Disease Witmentioning

confidence: 99%

Current Understanding of the Pathogenesis of Progressive Chronic Kidney Disease in Cats

Jepson

2016

Veterinary Clinics of North America: Small Animal Practice

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Abstract:In cats with chronic kidney disease (CKD), the most common histopathological finding is tubulointerstitial inflammation and fibrosis. However, these changes reflect a non-specific response of the kidney to any inciting injury. The risk of development of CKD in a patient is likely to reflect genetic predispositions, ageing, environmental and individual factors that influence decline in renal function over the course of a cat's life. However, there is still relatively little information about exactly which risk factors predispose a cat to develop CKD and these will be explored. Whilst many cats diagnosed with CKD have stable disease for many years, some cats show overtly progressive disease.

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Section: Association Of the Development Of Chronic Kidney Disease Witmentioning

confidence: 99%

Current Understanding of the Pathogenesis of Progressive Chronic Kidney Disease in Cats

Jepson

2016

Veterinary Clinics of North America: Small Animal Practice

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“…As leptospiras são sensíveis a uma ampla variedade de antibióticos, dentre eles a penicilina, ou derivados, e a doxiciclina (usada para eliminar as leptospiras dos túbulos renais). Desta forma, inicia-se o tratamento via intravenosa com penicilina ou derivados (penicilina G, ampicilina ou amoxicilina) para tratar a leptospiremia e finaliza-se com a doxiciclina para tratar a leptospiúria (Schuller et al 2015;Schuller 2017 , proteínas totais, albumina, globulina, bilirrubina total, bilirrubina conjugada e não conjugada), sumário de urina, soro-aglutinação microscópica e cultura de urina. Na avaliação sanguínea o animal apresentou anemia macrocítica hipocrômica, trombocitopenia, leucocitose por neutrofilia (Quadro 1), além de um aumento nos valores de uréia, AST, ALT e FA (Quadro 2).…”

Section: Pubvetunclassified

Leptospirose canina: Relato de caso

Silva

Rodrigues²,

Santana³

et al. 2018

Pubvet

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Leptospirosis is a zoonosis of worldwide distribution that has the dog as an important host, showing the importance of diagnosing and treating this animal that has a straight relationship with humans. A dog was attended at the Veterinary Hospital of the Federal University of Piauí in Teresina, Piauí, was present with history of hematuria, hyporexia and lethargy. Physical examination revealed lethargy, oral, ocular and penile icteric mucosa, pain at abdominal palpation and pyrexia. Hematologic analysis revealed hypochromic macrocytic anemia, thrombocytopenia, leukocytosis due to neutrophilia, and an increase in urea, AST, ALT, alkaline phosphatase and bilirubin values. The microscopic serum agglutination test showed a reactive result of Leptospira interrogans serovar Australis at the 1: 100 titre. The animal was effectively treated with Ampicillin, Doxycycline and supportive therapy.

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“…All animals were subject to a physical examination by a veterinarian to determine their health status. Given the variability of clinical presentations of canine leptospirosis (Langston & Heuter 2003, Sykes et al 2011, Schuller et al 2015, the possible clinical signs present in the dogs were considered as "primary" or "secondary" (Table 1) and the animals were classified as with "clinical suspicion of leptospirosis" if they met the following criteria: dogs that had at least one primary clinical sign with or without one secondary clinical sign.…”

Section: Methodsmentioning

confidence: 99%

“…In the last years, a re-emergence of leptospiral infection in pet populations in some geographic areas in the world have raised the concern about the disease (Damborg et al 2015, Major et al 2014. However, the understanding of their epidemiology and pathogenesis still is limited (Schuller et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic utility of an immunochromatography test for the detection of Leptospira IgM antibodies in domestic dogs

Azócar-Aedo

Smits²,

Monti

2017

Pesq. Vet. Bras.

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A cross-sectional study using 99 serum samples of dogs from southern Chile was conducted to determine the diagnostic utility of a rapid immunochromatography assay for the detection of Leptospira specific IgM antibodies as screening test and as a potential aid in the diagnosis of leptospirosis in animals with and without clinical suspicion of the disease. The Microscopic Agglutination Test (MAT) was used as reference assay. Anti-Leptospira antibodies were detected in 37.3% of the dogs with MAT. Using the immunochromatography test, specific IgM antibodies were found in 13.1% of sampled dogs. The sensitivity of the rapid test as screening assay was 29.7% (95% Confidence Interval=16.4-47.2) and the specificity was 96.7% (95% Confidence Interval=87.8-99.4). 40.0% of the canines with clinical suspicion of leptospirosis and 37.1% of dogs without clinical signs were serological reactors to MAT, but none of MAT reactive dogs with clinical suspicion tested positive in the rapid test. Rapid and user-friendly diagnostic procedures for canine leptospirosis such as this immunochromatography assay could be important tools to use in clinical practice, however, further studies are needed to obtain more information about their utility, considering that diagnostic tests could not have similar performances in different geographic locations, clinical and epidemiological contexts.

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European consensus statement on leptospirosis in dogs and cats

Cited by 241 publications

References 141 publications

Current Understanding of the Pathogenesis of Progressive Chronic Kidney Disease in Cats

Current Understanding of the Pathogenesis of Progressive Chronic Kidney Disease in Cats

Leptospirose canina: Relato de caso

Diagnostic utility of an immunochromatography test for the detection of Leptospira IgM antibodies in domestic dogs

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