European Crohn’s and Colitis Organisation Topical Review on Transitional Care in Inflammatory Bowel Disease

Rheenen, Patrick F. van; Aloi, Marina; Biron, I Avni; Carlsen, Katrine; Cooney, Rachel; Cucchiara, Salvatore; Cullen, Garret; Escher, Johanna C.; Kierkuś, Jarosław; Lindsay, James O.; Roma, Elefthería; Russell, Richard K.; Sieczkowska-Gołub, Joanna; Harbord, Marcus

doi:10.1093/ecco-jcc/jjx010

Cited by 81 publications

(105 citation statements)

References 45 publications

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“…85 In the latter disorders, IV iron preserves the normal microbiome, which would be disrupted by oral iron. 40 The European Crohn's and Colitis Organization recommends IV iron as a first-line therapy for patients with active disease and Hb ,10 g/dL and oral iron in inactive disease/mild anemia patients, 86 the latter being more likely to have absolute iron deficiency. IV iron is available in different forms; iron gluconate and iron sucrose require repeated infusions, whereas ferric carboxymaltose, ferumoxytol, low molecular weight iron dextran, and iron isomaltoside may be administered in high doses to rapidly replace the total iron deficit (usually 1-1.5 g) in 1 or 2 infusions.…”

Section: Ironmentioning

confidence: 99%

Iron deficiency

Camaschella¹

2019

Blood

472

415

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Iron deficiency anemia affects >1.2 billions individuals worldwide, and iron deficiency in the absence of anemia is even more frequent. Total-body (absolute) iron deficiency is caused by physiologically increased iron requirements in children, adolescents, young and pregnant women, by reduced iron intake, or by pathological defective absorption or chronic blood loss. Adaptation to iron deficiency at the tissue level is controlled by iron regulatory proteins to increase iron uptake and retention; at the systemic level, suppression of the iron hormone hepcidin increases iron release to plasma by absorptive enterocytes and recycling macrophages. The diagnosis of absolute iron deficiency is easy unless the condition is masked by inflammatory conditions. All cases of iron deficiency should be assessed for treatment and underlying cause. Special attention is needed in areas endemic for malaria and other infections to avoid worsening of infection by iron treatment. Ongoing efforts aim at optimizing iron salts–based therapy by protocols of administration based on the physiology of hepcidin control and reducing the common adverse effects of oral iron. IV iron, especially last-generation compounds administered at high doses in single infusions, is becoming an effective alternative in an increasing number of conditions because of a more rapid and persistent hematological response and acceptable safety profile. Risks/benefits of the different treatments should be weighed in a personalized therapeutic approach to iron deficiency.

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Section: Ironmentioning

confidence: 99%

Iron deficiency

Camaschella¹

2019

Blood

472

415

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“…The ECCO topical review on transition to adult care addresses in detail all aspects related to the steps to be followed during transition (447).…”

Section: Nutrition Growth and Bone Healthmentioning

confidence: 99%

Management of Paediatric Ulcerative Colitis, Part 1

Turner

Ruemmele

Orlanski-Meyer

et al. 2018

J. pediatr. gastroenterol. nutr.

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346

356

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“…The ECCO review suggests that transition is best initiated in early adolescence. 7 In European countries, the transfer of care is at the age of 18 years, but in the United States, this is often at the age of 21 years or even up to 25 years. 9 In the Asian context, adulthood may be considered at age 21 years and above.…”

Section: Determining the Ideal Timing For Transitionmentioning

confidence: 99%

Pediatric to adult inflammatory bowel disease transition: the Asian experience

Tan

Ong

2020

Intest Res

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and healthcare providers alike. Many studies have shown the efficacy of a standardized transition program, 5,6 and hence major organizations such as the European Crohn' s and Colitis Organisation (ECCO) 7 do recommend a transition program for every adolescent. Moreover, ECCO states that IBD patients taking part in a transition program are likely to have better compliance and less adverse outcomes after transfer to adult care compared with those who do not take part. However, there is a lack of clear guidelines on the specific recommendations for a standardized transition program. The authors believe that this may be attributed to the differences in the needs and expectations of IBD patients worldwide. Adolescence is a precarious period for growth and change, and the adolescent must shed the sheltered environment of childhood and achieve self-reliance and self-dependent living. Coupled with cultural differences and extent of parental involvement in patients' care, it is evident that various societies require different levels of intensity for a transition program. Pediatric and adult gastroenterology clinics also have different

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European Crohn’s and Colitis Organisation Topical Review on Transitional Care in Inflammatory Bowel Disease

Abstract: We present a consensus-based framework for transitional care in IBD that provides a guidance for clinical practice.

Cited by 81 publications

References 45 publications

Iron deficiency

Iron deficiency

Management of Paediatric Ulcerative Colitis, Part 1

Pediatric to adult inflammatory bowel disease transition: the Asian experience

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