European randomized, multicenter study of goserelin (Zoladex) in the management of mastalgia

Mansel, Robert Edward; Goyal, Amit; Preece, P. E.; Leinster, Sam; Maddox, P R; Gateley, Christopher; Kubista, E.; Fournier, D. von

doi:10.1016/j.ajog.2004.06.100

Cited by 43 publications

(31 citation statements)

References 15 publications

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“…It is not widely used and should be used with caution as it has been associated with pathological gambling and hypersexuality. & Goserelin (LHRH analog): Goserelin in a placebocontrolled randomized trial of 147 premenopausal cases showed a significant reduction in mean days with severe pain from 17.6 to 5.9, i.e., 67 % reduction [37]. It is effective in recurrent mastalgia and mastalgia not responding to other hormonal therapies.…”

Section: Hormone Replacement Therapy and Breast Painmentioning

confidence: 99%

A Systematic Review of Current Understanding and Management of Mastalgia

et al. 2013

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Breast pain or mastalgia is the common symptom in the breast. The two most common concerns of patients presenting with mastalgia are: the fear that breast pain is a symptom of breast cancer and the presence of severe pain that affects a woman's quality of life. Breast pain requires thorough assessment and should be investigated in the same manner as any other breast symptom. We conducted a systematic review of treatment for breast pain. We searched various reviews, randomized controlled trial, and observational studies over Pubmed and Medline via internet. Searches were carried out on MEDLINE

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Section: Hormone Replacement Therapy and Breast Painmentioning

confidence: 99%

A Systematic Review of Current Understanding and Management of Mastalgia

et al. 2013

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“…Increased Prolactin secretion Many pharmacological agents have been tried in the therapy of mastalgia. The drug therapy includes agents inducing hormonal manipulation such as Danazol [4], Bromocriptine [5], Tamoxifen [6], and LH-RH [7] analogue like Goserelin. Some of the effective non-hormonal agents in mastalgia are Non-steroidal anti-inflammatory gels [8], reassurance [9] and breast support with sport's bra [10].…”

Section: Introductionmentioning

confidence: 99%

Centchroman Regresses Mastalgia: A Randomized Comparison with Danazol

et al. 2010

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We conducted a randomized trial to evaluate effectiveness of Centchroman in control of mastalgia and compared it with Danazol. Research Question-Is proportion of pain relief achieved by Centchroman similar to or inferior to that achieved by Danazol? In a randomized controlled trial of Centchroman vs. Danazol in mastalgia, 81 patients with mastalgia were studied. Thirty-nine patients were randomized to Danazol arm and 42 in Centchroman arm. The treatment was given for 12 weeks, followed by observation for 12 weeks. The pain was measured by visual analogue scale (VAS) of 0-10. At 12 weeks 89.7% women achieved reduction in pain score to ≤3 in Centchroman group (pvalue 0.001). In Danazol group 69.44% women achieved reduction in pain score to ≤ 3 (p=0.001). Three months after stopping therapy, Centchroman was more effective in pain score reduction at 24 weeks as compared to Danazol (p=0.019). Centchroman is an effective, safe and inexpensive alternative to Danazol for treatment of mastalgia.

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“…There is considerable discussion about selecting the best method for the primary management of breast pain (14) . Recently, Centchroman (Ormeloxifenec30 H35NO3) a non-hormonal, non-steroidal oral contraceptive pill (15) is being used in mastalgia.…”

Section: Discussionmentioning

confidence: 99%