This paper delves into regional airport system economics in Central Europe, with a particular focus on Slovakia, Czechia, Poland, Hungary, and Croatia. This research aimed to identify key indicators that shape optimal business models for regional airport systems by analyzing data from 24 airports between 2016 and 2019. Through cluster analysis, airports were categorized based on performance metrics, economic indicators, and ownership structures. The findings reveal distinct groupings among regional airports and shed light on critical factors influencing their operational and financial dynamics. By offering insights into the relationships between airport system characteristics and business model effectiveness, this paper aimed to provide valuable guidance for stakeholders, policymakers, and airport management teams. It facilitates informed decision-making and strategic planning for sustainable aviation infrastructure development in the region.