Abstract:Background:In an increasingly co-morbid population there are significant challenges to diagnosing the cause of breathlessness, and once diagnosed, considerable difficulty in detecting deterioration early enough to provide effective intervention. The burden of the breathless patient on the healthcare economy is substantial with asthma, chronic heart failure and pneumonia affecting over 6 million people in the UK alone. Furthermore these patients often have more than one contributory factor to their breathlessness symptoms, with conditions such as dysfunctional breathing pattern disorders (BPD) an under recognised component. Current methods of diagnosing and monitoring breathless conditions can be extensive and difficult to perform, as a consequence home monitoring is poorly complied with. In contrast capnography (the measurement of tidal breath carbon dioxide) is performed during normal breathing. There is a need for a simple, easy-to-use personal device that can aid in the diagnosis and monitoring of respiratory and cardiac causes of breathlessness.
Objective:We will explore the use of a new, handheld capnometer (called the N-Tidal C) in different conditions that cause breathlessness. We will study whether the Tidal Breath Carbon Dioxide (TBCO 2 ) waveform, as measured by the N-Tidal C, has different characteristics in a range of respiratory and cardiac conditions.
Methods:We will perform a longitudinal, observational study of the TBCO 2 waveform (capnogram) as measured by the N-Tidal C™ capnometer. Participants with a confirmed diagnosis of asthma, breathing pattern disorder, chronic heart failure, motor neurone disease, pneumonia and volunteers with no history of lung disease will be asked to provide twice daily, 75 second TBCO 2 collection via the N-Tidal C device for 6 months duration. The collated capnograms will be correlated with the underlying diagnosis and disease state (stable or exacerbation) to determine if there are different TBCO2 characteristics that can distinguish different respiratory and cardiac causes of breathlessness.
Results:This study's recruitment is ongoing, it is anticipated the results will be available in late 2018.
Conclusion:The GBRS study will provide an evaluation of the use of capnography as a diagnostic and home monitoring tool for various diseases.