European Society of Clinical Microbiology and Infectious Diseases/European Committee on infection control clinical guidelines on pre-operative decolonization and targeted prophylaxis in patients colonized by multidrug-resistant Gram-positive bacteria before surgery

Righi, Elda; Mutters, Nico T.; Guirao, Xavier; Dolores del Toro, Maria; Eckmann, Christian; Friedrich, Alex W.; Giannella, Maddalena; Presterl, Elisabeth; Christaki, Eirini; Cross, Elizabeth L.A.; Visentin, Alessandro; Sganga, Gabriele; Tsioutis, Constantinos; Tacconelli, Evelina; Kluytmans, Jan

doi:10.1016/j.cmi.2024.07.012

Clinical Microbiology and Infection

2024

DOI: 10.1016/j.cmi.2024.07.012

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European Society of Clinical Microbiology and Infectious Diseases/European Committee on infection control clinical guidelines on pre-operative decolonization and targeted prophylaxis in patients colonized by multidrug-resistant Gram-positive bacteria before surgery

Elda Righi,

Nico T. Mutters,

Xavier Guirao

et al.

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Antimicrobials in Orthopedic Infections: Overview of Clinical Perspective and Microbial Resistance

Huzum,

Aprotosoaie,

Alexa

et al. 2024

Medicina

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Orthopedic infections are challenging pathologies that impose a heavy burden on patients and the healthcare system. Antimicrobial therapy is a critical component of the successful management of orthopedic infections, but its effectiveness depends on patient-, surgery-, drug-, and hospital-related factors. The dramatic increase in the emergence of multidrug-resistant microbial strains necessitates new clinical approaches in order to prevent or limit this phenomenon and to ensure a favorable therapeutic outcome. The present paper reviews the currently available antimicrobial strategies in the management of orthopedic infections, highlighting their clinical use related to the occurrence of microbial resistance. Some approaches for reducing antibiotic resistance emergence in orthopedics are also presented. The use of antibiotics tailored to the microorganism’s sensitivity profile, patient factors, and pharmacokinetic profile in terms of monotherapy or combinations, the understanding of microbial pathogenicity and resistance patterns, strict control measures in healthcare facilities, the development of new antimicrobial therapies (drugs, devices, technologies), and patient education for improving compliance and tolerance are some of the most important tools for overcoming microbial resistance.

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Antimicrobials in Orthopedic Infections: Overview of Clinical Perspective and Microbial Resistance

Huzum,

Aprotosoaie,

Alexa

et al. 2024

Medicina

View full text Add to dashboard Cite

show abstract

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European Society of Clinical Microbiology and Infectious Diseases/European Committee on infection control clinical guidelines on pre-operative decolonization and targeted prophylaxis in patients colonized by multidrug-resistant Gram-positive bacteria before surgery

Cited by 1 publication

References 77 publications

Antimicrobials in Orthopedic Infections: Overview of Clinical Perspective and Microbial Resistance

Antimicrobials in Orthopedic Infections: Overview of Clinical Perspective and Microbial Resistance

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