European Society of Clinical Pharmacy international workshop on patient safety and pharmacy

doi:10.1007/s11096-010-9417-6

Cited by 1 publication

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two studies assessed the economic impact of adherence to immunosuppressants among patients undergoing kidney transplantation,9,61 and one observational study evaluated compliance with interventions for liver transplantation 62. Abecassis et al61 modeled patient outcomes and treatment costs over 5 years for renal transplant comparing BID with OD tacrolimus (Table 4).…”

Section: Resultsmentioning

confidence: 99%

“…Over 5 years, the OD regimen yielded cumulative cost savings relative to BID of £104,534, including savings in drug acquisition (£69,180), management of acute rejection episodes (£22,837), retransplantation (£417), and dialysis (£13,631) 9. Further, Eberlin and Kramer62 demonstrated that switching patients from BID to OD tacrolimus-based regimen for liver transplantation resulted in a trend towards better compliance with OD regimen.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Impact of reducing dosing frequency on adherence to oral therapies: a literature review and meta-analysis

Srivastava¹,

Arora²,

Kataria³

et al. 2013

PPA

View full text Add to dashboard Cite

ObjectivesTo assess the impact of reduced frequency of oral therapies from multiple-dosing schedules to a once-daily (OD) dosing schedule on adherence, compliance, persistence, and associated economic impact.MethodsA meta-analysis was performed based on relevant articles identified from a comprehensive literature review using MEDLINE® and Embase®. The review included studies assessing adherence with OD, twice-daily (BID), thrice-daily (TID), and four-times daily (QID) dosing schedules and costs associated with optimal/suboptimal adherence among patients with acute and chronic diseases. Effect estimates across studies were pooled and analyzed using the DerSimonian and Laird random-effect model.ResultsForty-three studies met inclusion criteria, and meta-analyzable data were available from 13 studies. The overall results indicated that OD schedules were associated with higher adherence rates (odds ratio [OR] 3.07, 95% confidence interval [CI] 1.80–5.23; P < 0.001 for OD versus > OD dosing) and compliance rates (OR 3.50, 95% CI 1.73–7.08; P < 0.001 for OD versus > OD dosing); persistence rates showed the same direction but were not statistically significant (OR 1.43, 95% CI 0.62–3.29; P = 0.405 for OD versus BID dosing). Results for each of the conditions were consistent with those observed overall with respect to showing the benefits of less frequent dosing. From a health economic perspective, higher adherence rates with OD relative to multiple dosing in a number of conditions were consistently associated with corresponding lower costs of health care resources utilization.ConclusionCurrent meta-analyses suggested that across acute and chronic disease states, reducing dosage frequency from multiple dosing to OD dosing may improve adherence to therapies among patients. Improving adherence may result in subsequent decreases in health care costs.

show abstract