European Tobacco Products Directive (TPD): current impact and future steps

Vardavas, Constantine

doi:10.1136/tobaccocontrol-2021-056548

Cited by 17 publications

(12 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such an observation is important, as it not only sheds light on the necessity of reducing the nicotine addictiveness of tobacco products, including the recently announced proposed rules by the Food and Drug Administration [ 52 ] of establishing a maximum level of nicotine in cigarettes, but also points out that e-liquids with a high nicotine strength unavoidably promote higher nicotine consumption. Regulations on e-liquid nicotine concentrations (ie, maximum nicotine concentration of 20 mg/mL in the European Tobacco Products Directive [TPD] [ 53 ]) should be further considered to reduce nicotine addiction risks.…”

Section: Discussionmentioning

confidence: 99%

A Novel Puff Recording Electronic Nicotine Delivery System for Assessing Naturalistic Puff Topography and Nicotine Consumption During Ad Libitum Use: Ancillary Study

Gao¹,

Fewx²,

Sprock³

et al. 2023

JMIR Form Res

View full text Add to dashboard Cite

Background Assessing the naturalistic puff topography and associated nicotine consumption during e-cigarette use is important as such information will not only unveil how these products are being consumed in real-world conditions, but also enable investigators and regulatory bodies to conduct quantitative, accurate, and realistic harmful exposure and nicotine abuse liability risk assessments based on actual e-cigarette use. Conventional approaches cannot accurately, conveniently, and noninvasively determine e-cigarette puff topography in a natural use environment. Thus, novel technology-enabled systems that do not primarily rely on self-report mechanisms or intrusive measurements to monitor e-cigarette product use behaviors are highly desired. Objective This study aimed to explore and demonstrate the feasibility of a novel puff recording electronic nicotine delivery system (PR-ENDS) device for measuring naturalistic puff topography and estimating nicotine consumption during the ad libitum use of products among smokers and vapers. Methods An ancillary data analysis based on a completed parent study was conducted. The parent study was a 1-way randomized controlled open-label puff topography and nicotine pharmacokinetic assessment carried out in 24 healthy adults (12 smokers and 12 vapers). Participants were assigned a randomized product use sequence of a PR-ENDS device within 5 site visits for both controlled and ad libitum product use sessions. Blood samples were obtained for plasma nicotine analysis, and questionnaires were administered at various time points. During the ad libitum use session, puff topography was measured using a Clinical Research Support System (CReSS) device as a benchmark, as well as the PR-ENDS device with a built-in puff recording feature. Results There were no significant differences in representative puff topography parameters (number of puffs, total puff duration, and average puff duration) between the PR-ENDS and CReSS devices at the populational level across different device powers, e-liquid nicotine strengths, and flavors. The nicotine consumption estimated by the PR-ENDS device suggested that this device can be employed as a convenient monitoring tool for estimating nicotine use without measuring e-liquid weight loss between puffs. The linear relationship between nicotine consumption estimated by the PR-ENDS device and the pharmacokinetic parameter AUCad lib (plasma concentration-time curve for 1-hour ad libitum use) substantiated the potential of using this device as a pragmatic, noninvasive, and convenient means for estimating nicotine intake in the human body without blood collection. Conclusions The novel PR-ENDS device was feasible for assessing naturalistic puff topography and estimating nicotine consumption and intake in the human body during ad libitum use. Several key factors can influence users’ puff topography, including device power levels, e-liquid nicotine strengths, and flavors. The study results pave the way for further research in the real-time measurement of naturalistic puff topography and puffing behaviors in the real world.

show abstract

Section: Discussionmentioning

confidence: 99%

A Novel Puff Recording Electronic Nicotine Delivery System for Assessing Naturalistic Puff Topography and Nicotine Consumption During Ad Libitum Use: Ancillary Study

Gao¹,

Fewx²,

Sprock³

et al. 2023

JMIR Form Res

View full text Add to dashboard Cite

show abstract

“…For example, Japan's unique regulatory model favours HTP use because it allows for the promotion and sale of HTPs while banning nicotine-containing e-cigarettes-a key competitor to HTPs [78]. HTPs are also legal and regulated under the Tobacco Products Directive as a novel tobacco product for countries in the European Union [79]. For England, HTPs are legal and regulated under the Tobacco and Related Products Regulation [80].…”

Section: Meta-regressionmentioning

confidence: 99%

Global prevalence of heated tobacco product use, 2015–22: A systematic review and meta‐analysis

et al. 2023

View full text Add to dashboard Cite

Background and Aims: Heated tobacco products (HTPs) are electronic devices that heat process tobacco to release an aerosol containing nicotine and other chemicals. Limited data exist on world-wide HTP use prevalence. This meta-analytic review estimated the prevalence of HTP use by country, World Health Organization (WHO) region, year, sex/gender and age. Methods: Five databases (Web of Science, Scopus, Embase, PubMed and PsycINFO) were searched between January 2015 and May 2022. Included studies reported the prevalence of HTP use in nationally representative samples post-modern HTP device market entry (2015). A random-effects meta-analysis was used to estimate overall prevalence for life-time, current and daily HTP use. Results: Forty-five studies (n = 1 096 076) from 42 countries/areas from the European Region (EUR), Western Pacific Region (WPR), Region of the Americas (AMR) and African Region (AFR) met inclusion criteria. Estimated pooled prevalence for life-time, current and daily HTP use was 4.87% [95% confidence interval (CI) = 4.16, 5.

show abstract

“…Vapers in many European countries were previously cigarette users or started smoking at a young age, and some of these nations even reported a higher prevalence of e-cigarette use than traditional cigarette use (e.g., Iceland, Monaco, Lithuania, Poland, Ireland, Germany, Czechia, Hungary, France, and Norway) [ 12 ]. After the implementation of the EU Tobacco Products Directive regulations, e-cigarette use among young people in European nations, including the UK, is slowing down [ 13 , 14 ]. However, unlike other countries, England still shows an increase in past and current e-cigarette use from 2014 to 2016 [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…After the implementation of the EU Tobacco Products Directive regulations, e-cigarette use among young people in European nations, including the UK, is slowing down [ 13 , 14 ]. However, unlike other countries, England still shows an increase in past and current e-cigarette use from 2014 to 2016 [ 13 , 14 ]. Despite the significance of these findings, there has been a lack of data on the pooled prevalence of young people’s e-cigarette use.…”

Section: Introductionmentioning

confidence: 99%

An International Systematic Review of Prevalence, Risk, and Protective Factors Associated with Young People’s E-Cigarette Use

Kim

Lee

Chun

2022

IJERPH

View full text Add to dashboard Cite

While the prevalence of young people’s conventional cigarette use has decreased in many countries, the use of e-cigarettes has risen. To effectively counteract the growing popularity of e-cigarettes among young people internationally, researchers should know the exact prevalence as well as the protective and risk factors associated with vaping. Based on five eligibility criteria, 53 articles were chosen and analyzed by general characteristics, prevalence, sample characteristics, gender difference, protective factors, and risk factors. In this study, the international pooled prevalence of young people’s lifetime e-cigarette use was 15.3%, the current use was 7.7%, and dual use was 4.0%. While the highest lifetime, current, and dual prevalence were found in Sweden, Canada, and the United Kingdom, respectively, the lowest prevalence was found in Germany, followed by South Korea and Sweden. Some protective and risk factors include perceived cost and danger of vaping, parental monitoring, internal developmental assets, cigarette use, family and peer smoking, exposure to online advertisements, and the presence of nearby retail stores. Based on this review, researchers and practitioners can develop different intervention programs and strategies for young smokers.

show abstract

European Tobacco Products Directive (TPD): current impact and future steps

Cited by 17 publications

References 30 publications

A Novel Puff Recording Electronic Nicotine Delivery System for Assessing Naturalistic Puff Topography and Nicotine Consumption During Ad Libitum Use: Ancillary Study

A Novel Puff Recording Electronic Nicotine Delivery System for Assessing Naturalistic Puff Topography and Nicotine Consumption During Ad Libitum Use: Ancillary Study

Global prevalence of heated tobacco product use, 2015–22: A systematic review and meta‐analysis

An International Systematic Review of Prevalence, Risk, and Protective Factors Associated with Young People’s E-Cigarette Use

Contact Info

Product

Resources

About