Soil moisture is an important variable for land-climate and hydrological interactions. To investigate emergent large-scale, long-term interactions between soil moisture and other key hydro-climatic variables (precipitation, actual evapotranspiration, runoff, temperature), we analyze monthly values and anomalies of these variables in 1378 hydrological catchments across Europe over the period 1980-2010. The study distinguishes results for the main European climate regions, and tests how sensitive or robust they are to the use of three alternative observational and re-analysis datasets. Robustly across the european climates and datasets, monthly soil moisture anomalies correlate well with runoff anomalies, and extreme soil moisture and runoff values also largely co-occur. For precipitation, evapotranspiration, and temperature, anomaly correlation and extreme value co-occurrence with soil moisture are overall lower than for runoff. The runoff results indicate a possible new approach to assessing variability and change of large-scale soil moisture conditions by use of long-term time series of monitored catchment-integrating stream discharges. Soil moisture is recognized as an important variable for land-climate interactions and extreme events 1-3 as well as for hydrology and its extremes in the landscape 4,5. For quantification of this variable, focus has been largely concentrated on the near-surface domain (Fig. 1a), for example in assessments of soil moisture variability over the landscape 6 and in land-surface schemes of Earth System Models (ESMs) 7. However, the depth-extent of the vadose zone down to the groundwater table, over which soil moisture (water content, degree of saturation) varies in time, is in itself a dynamic variable 8. In this variable vadose zone extent, soil moisture variations interact with precipitation and actual evapotranspiration (ET), and these near-surface variations are commonly accounted for in ESMs and surface-focused hydrological modelling 9 (Fig. 1a). However, along the subsurface water pathways (Fig. 1b), soil moisture also interacts with the groundwater table depth and its variations 8 , and further with the runoff and stream discharge generation 10 that is fed by the variable groundwater flow (as driven by the groundwater level variations) over each hydrological catchment. The complex interactions and degrees of co-variation of soil moisture with precipitation, ET and runoff, through groundwater changes, are often insufficiently represented in large-scale modelling, e.g., by ESMs 7 , and remain largely unresolved for different climate conditions 4,11. Furthermore, also hydrological models often perform poorly under changing conditions 12-14 , which include the change interactions of soil moisture with vegetation and ET (Fig. 1a) as well as with groundwater 8 and runoff 10 (Fig. 1b). Regarding the latter, however, surface-focused modelling only considers a single term of water "loss" to groundwater (blue in Fig. 1a). From a scientific perspective, it is essential to know the degree...